PPP6C

Gene Information

Official Symbol: PPP6C
Official Name: protein phosphatase 6 catalytic subunit
Aliases and Previous Symbols: N/A
Entrez ID: 5537
UniProt: O00743
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation. {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:9013334}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-3.52
Cerivastatin 0.15μM R05 exp226	-2.37
YM155 0.001μM R08 exp432	-2.34
Parthenolide 2.5μM R05 exp238	-2.27
EPZ-5676 30μM R05 exp233	-2.14
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.08
Vincristine 0.0005μM R04 exp190	-2.04
UM0011500 5μM R05 exp245	-1.94
TNF-alpha 44ng/ml R08 exp533	-1.93
Pyridostatin 4μM R05 exp240	-1.91
BN82002 4μM R07 exp340	-1.83
Fas-L 44ng/ml R08 exp482	-1.81
Pyrazinamide 100μM R08 exp516	-1.79
Apcin 50 to 100μM on day4 R04 exp176	-1.76
Cisplatin 0.35μM R06 exp273	-1.75
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.71
Mitomycin-C 0.06μM R08 exp503	1.7
BI-6727 0.04μM R03 exp98	1.78
PU-H71 1μM R08 exp515	1.83
Rotenone 2μM R00 exp33	1.83
TIC10 10μM R08 exp532	1.85
Thapsigargin 0.005μM R07 exp407	1.87
FK-506 30μM R07 exp359	1.89
Salubrinal 20μM R07 exp399	1.93
SNS-032 15μM R08 exp443	1.93
BI-2536 0.02μM R03 exp96	1.94
Rotenone 0.07μM R08 exp431	2
Benzoate 20000μM R08 exp456	2.05
Bleomycin 5μM R08 exp459	2.08
Dorsomorphin 5μM R07 exp357	2.09
Centrinone 0.5μM R07 exp343	2.11
Milciclib 2μM R08 exp502	2.15
ONC212 0.15μM R08 exp513	2.22
Mdivi-1 15μM R05 exp217	2.27
Senexin-A 25μM R07 exp400	2.27
UM131593 0.2μM R03 exp106	2.28
AICAR 240μM R05 exp211	2.36
Cannabidiol 20μM R08 exp466	2.37
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.39
Rotenone 20μM R00 exp34	2.39
Vinblastine 0.2μM R03 exp108	2.43
5-Fluorouracil 20μM R00 exp2	2.45
UMK57 1μM R01 exp59	2.67
Bisphenol A 100μM R06 exp269	2.69
Aminopterin 0.005μM R07 exp335	2.8
RO-3307 4.7μM R02 exp80	2.92
Ammonium tetrathiomolybdate 10μM R08 exp448	3.13
Cannabidiol 13μM R08 exp465	3.13
Lead acetate 2000μM R08 exp497	3.22
∆-9-Tetrahydrocannabinol 30μM R08 exp445	3.33
iCRT14 30μM R08 exp492	3.97
Lead acetate 2000μM R08 exp498 no dilution day6	3.97
BVD-523 15μM R02 exp67	4.1
Actinomycin-D 0.001μM R00 exp3	4.21
UM0129480 7μM R02 exp85	4.46

Gene	Correlation
FH	0.574
THG1L	0.56
PTAR1	0.548
DR1	0.531
GEMIN8	0.528
PPP2R4	0.523
BAP1	0.52
KCTD5	0.519
RABGGTB	0.517
GEMIN6	0.517
ALG1	0.516
MBTPS2	0.509
ATXN10	0.507
RPP21	0.507
LSM10	0.504
UAP1	0.501
DDX42	0.5
GEMIN7	0.499
DOHH	0.497
CBX3	0.493
ADSL	0.491
UHRF1	0.49
SRP14	0.488
PPCS	0.488
PDAP1	0.487
ZCRB1	0.485
PPP4C	0.482
TMEM242	0.482
RFT1	0.481
DPAGT1	0.473
C15orf41	0.468
VEZT	0.468
RPTOR	0.467
NAE1	0.465
CYB5R4	0.464
WRB	0.464
RTCB	0.462
ZRSR2	0.462
PPCDC	0.459
LCMT1	0.459
PMM2	0.458
EXOC4	0.457
ATP5B	0.457
SLC25A19	0.457
PGM3	0.457
LSM11	0.453
TRMT5	0.451
GTF3C6	0.45
GMPPB	0.45
DHRSX	0.449
RPIA	0.448
UBA3	0.448
CXorf56	0.448
MSTO1	0.445
TTC4	0.444
TEN1	0.442
URM1	0.441
TPK1	0.44
BAK1	0.435
UBE2M	0.434
TBCB	0.434
AASDHPPT	0.434
GEMIN4	0.433
ATP5O	0.433
DDX1	0.433
DPH1	0.432
ANKRD52	0.431
SSB	0.43
ELP3	0.43
TSEN54	0.427
ALG6	0.425
FEN1	0.424
TRMT61A	0.423
ELP2	0.422
ATP5J	0.419
GFPT1	0.418
N6AMT1	0.418
CEP57	0.418
ATP5A1	0.416
FAF2	0.415
TRIM28	0.415
SNAPC5	0.415
GTF3C3	0.415
BRWD1	0.414
DDX39A	0.414
TUBE1	0.413
PPP2R3C	0.412
PDCD6IP	0.412
TIMM10	0.412
SPR	0.412
PDCD5	0.411
TUBD1	0.411
ATIC	0.411
SRRD	0.411
PELO	0.409
GTF3C4	0.407
EGLN1	0.406
KDM8	0.405
BCS1L	0.404
SLC25A26	0.403
TUT1	0.402
TAF1A	0.401
HARS	0.4

Global Fraction of Cell Lines Where Essential: 396/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	18/28
blood	14/28
bone	11/26
breast	24/33
central nervous system	20/56
cervix	2/4
colorectal	11/17
esophagus	9/13
fibroblast	1/1
gastric	9/16
kidney	10/21
liver	12/20
lung	38/75
lymphocyte	11/16
ovary	14/26
pancreas	14/24
peripheral nervous system	3/16
plasma cell	9/15
prostate	0/1
skin	18/24
soft tissue	3/9
thyroid	2/2
upper aerodigestive	12/22
urinary tract	21/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 174
Expression level (log2 read counts): 5.92

Expression Distribution

COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
protein serine/threonine phosphatase activity
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
protein dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
vesicle organization
dephosphorylation
establishment of organelle localization
Golgi vesicle transport
organelle localization
mitotic cell cycle process
Golgi membrane
mitotic cell cycle
innate immune response
membrane organization
defense response to other organism
cell cycle process
mitochondrion
response to other organism
response to external biotic stimulus
response to biotic stimulus
cell cycle
defense response
intracellular transport
protein-containing complex assembly
establishment of localization in cell
protein-containing complex subunit organization
immune response