ATP6V1C1

Gene Information

Official Symbol: ATP6V1C1
Official Name: ATPase H+ transporting V1 subunit C1
Aliases and Previous Symbols: N/A
Entrez ID: 528
UniProt: P21283
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
42°C R08 exp539	-2.07
Tanespimycin 14μM R08 exp527	-1.91
BI-2536 0.02μM R03 exp96	-1.84
Pimelic-diphenylamide-106 5μM R00 exp28	-1.83
Mitomycin-C 0.06μM R08 exp503	-1.75
BVD-523 15μM R02 exp67	-1.72

Gene	Correlation
PSMB4	0.576
PRIM1	0.54
PSMA6	0.536
COPG1	0.534
CDC6	0.53
FAM25B	0.529
TCEB3C	0.526
SEC13	0.525
CACTIN	0.523
COPB1	0.518
ORC6	0.517
SNRPA1	0.517
KCTD17	0.516
UPF1	0.515
SUPT5H	0.513
TFIP11	0.512
SF3A2	0.512
TSG101	0.503
POLE	0.499
CDCA3	0.498
TCEB3CL	0.495
RBM39	0.494
IK	0.493
STIL	0.493
MT1E	0.491
ORC1	0.49
SLC6A17	0.488
CHD4	0.487
RPS19BP1	0.487
CCNA2	0.486
ZNF655	0.485
TBC1D3G	0.483
ZNF541	0.482
NUPL1	0.482
HGC6.3	0.482
NUP160	0.478
OSBP	0.478
TBC1D3F	0.477
PSMB2	0.477
COPZ1	0.474
TCEB3CL2	0.474
CBWD6	0.473
UTP3	0.472
NARFL	0.471
C2orf27B	0.47
SNRNP70	0.47
CBWD3	0.47
BRD2	0.47
SLC4A1	0.469
ATP6V1B2	0.469
EXOSC3	0.469
ARCN1	0.469
SAP30BP	0.465
DNTTIP2	0.465
PRPF19	0.465
VPS54	0.464
LRR1	0.464
TBC1D3H	0.461
CBWD5	0.461
ATP6V0B	0.46
RPL35	0.46
CKAP5	0.46
VASN	0.46
ATP6V1A	0.459
HIST2H2BF	0.458
SYT9	0.458
RRP15	0.457
PSMD14	0.457
PSMD3	0.456
DTL	0.456
ACSF2	0.456
HIST1H2BE	0.452
CHAF1A	0.452
CDC45	0.452
NAPA	0.451
GOLGA6L1	0.451
CTAGE4	0.451
PSMB3	0.448
OR10G3	0.448
RPS12	0.448
EIF4A3	0.446
TSPY8	0.446
TBC1D3	0.446
SH3BP1	0.446
NPIPB5	0.446
ISCU	0.445
RPLP1	0.444
CHMP4B	0.444
CEP192	0.443
POLR2J3	0.442
POLR2A	0.442
RAD51	0.441
C14orf93	0.441
TP53TG3B	0.441
RRP7A	0.441
NSF	0.44
PSMC1	0.44
TP53TG3C	0.44
TP53TG3	0.44
ZNF148	0.438
BYSL	0.438
RPS2	0.435
NPIPA7	0.433
GOSR2	0.433
NPIPA8	0.433
FAM160A1	0.432
HTATSF1	0.432
MMS22L	0.431
MYO1H	0.431
TICRR	0.431
CLN6	0.431
PWP2	0.431
NBPF10	0.43
TIMELESS	0.43
PSMD7	0.428
STRN	0.428
NOL10	0.427
EXOSC4	0.427
KRT78	0.427
NUP85	0.427
MYB	0.427
EXOSC5	0.426
SNX15	0.426
DDT	0.425
EXOSC6	0.425
ATP6AP1	0.424
TBC1D3C	0.423
ZNF830	0.422
DDTL	0.422
SKIV2L2	0.421
TWISTNB	0.421
TUBA8	0.421
CTAGE9	0.421
CDC73	0.42
RNF113A	0.42
RAD21	0.419
DIDO1	0.419
RPL30	0.419
PPIE	0.419
COPE	0.418
SF3A1	0.418
GOLGA8J	0.417
PLEKHA4	0.417
SAMD1	0.417
MYLK3	0.416
IGFN1	0.416
TRAPPC11	0.416
TYMS	0.415
AATF	0.413
PSMA7	0.413
AKIRIN2	0.412
RRM2	0.412
SF3A3	0.412
NIPBL	0.412
POLA2	0.411
C1QTNF9B	0.411
NUFIP2	0.41
COPB2	0.409
OGFR	0.409
DOCK6	0.409
SETD1A	0.408
TBC1D3E	0.408
TBC1D3L	0.408
TBC1D3K	0.408
ACD	0.407
TBC1D3I	0.407
TRAPPC8	0.407
RRN3	0.404
PSMD2	0.404
SULT2B1	0.404
TPX2	0.404
PLA2G4F	0.403
PLRG1	0.403
XYLT2	0.403
CSNK1A1	0.403
CDC5L	0.402
TRAIP	0.402
PLK4	0.402
RPP40	0.402
POLR2F	0.401
SSH2	0.401
RNPC3	0.401
AQR	0.4
SUPT6H	0.4
FCN2	0.4
PDE4DIP	0.4

Global Fraction of Cell Lines Where Essential: 84/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	2/28
bone	4/26
breast	2/33
central nervous system	3/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	1/1
gastric	0/16
kidney	7/21
liver	3/20
lung	11/75
lymphocyte	1/16
ovary	1/26
pancreas	4/24
peripheral nervous system	3/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 955
Expression level (log2 read counts): 6.08

Expression Distribution