CHCHD1

Gene Information

Official Symbol: CHCHD1
Official Name: coiled-coil-helix-coiled-coil-helix domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 118487
UniProt: Q96BP2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCCP 1μM R00 exp11	-2.18
2-Deoxy-D-glucose 800μM R05 exp214	-2.08
CB-839 10μM R05 exp224	-1.91
Vemurafenib 6.6μM R08 exp434	1.7
MK-1775 0.32μM R02 exp75	1.73
HMS-I2 10μM R06 exp288	1.86
Palbociclib 1μM R07 exp382	1.89
Ribavirin 10 to 15μM on day4 R04 exp160	1.89
Genistein 15μM R07 exp360	1.91
Oligomycin-A 2μM R00 exp25	2.14
Hydroxyurea 100μM R07 exp329	2.25
Tubacin 1.6μM R07 exp416	2.3

Gene	Correlation
ACAD9	0.597
MTO1	0.594
GRSF1	0.585
NDUFB11	0.583
MTG1	0.577
NDUFA2	0.575
METTL17	0.575
MRPL21	0.569
GTPBP10	0.567
NDUFS2	0.567
NDUFA11	0.566
MRPL45	0.565
NDUFA1	0.561
GFM2	0.56
MTG2	0.557
NDUFAF7	0.553
NDUFA3	0.549
NDUFAF3	0.543
HMGXB3	0.542
NDUFC2	0.542
QRSL1	0.54
SSBP1	0.537
NDUFB7	0.537
MRPS21	0.537
FASTKD2	0.536
MALSU1	0.535
NDUFB10	0.533
MRPL47	0.533
MRPS5	0.531
MRPL53	0.531
MRPS34	0.531
FTSJ2	0.529
NDUFB9	0.527
POLRMT	0.519
PET117	0.519
MTRF1L	0.517
RPUSD3	0.511
HSD17B10	0.511
GFM1	0.503
MRPL49	0.502
C12orf65	0.501
MRP63	0.501
MRPS12	0.496
NARS2	0.495
NDUFAF6	0.494
RPUSD4	0.493
MRPL23	0.491
NDUFS7	0.49
COQ7	0.49
NDUFB6	0.486
ECSIT	0.483
AIFM1	0.482
MRPS26	0.482
MRPL3	0.481
MRPS6	0.481
NDUFS8	0.481
PTCD3	0.481
PET112	0.481
NUBPL	0.479
ERAL1	0.478
PNPT1	0.478
RBFA	0.478
NDUFV1	0.478
MRPL13	0.477
TARS2	0.476
MRPS2	0.476
MRPL15	0.476
NDUFB5	0.475
MRPS14	0.475
PARS2	0.472
MTERFD1	0.472
COX6B1	0.472
COA3	0.472
MRPL44	0.47
MRPL4	0.47
NDUFA10	0.469
COQ2	0.469
MRPS16	0.469
COX16	0.469
NDUFB2	0.469
DDX28	0.468
TRUB2	0.468
NDUFC1	0.467
MTIF2	0.467
WBSCR16	0.466
RTN4IP1	0.466
FASTKD5	0.465
FARS2	0.465
LARS2	0.464
MRPL43	0.464
MRPS25	0.461
CARS2	0.461
SELRC1	0.461
MRPL1	0.46
MIPEP	0.458
MTPAP	0.457
MTERFD2	0.457
IBA57	0.456
RNASEH1	0.455
DAP3	0.455
NDUFAF1	0.454
AARS2	0.453
MCAT	0.452
NDUFS5	0.451
MRPS9	0.449
NDUFAF5	0.449
TMEM261	0.447
POLG2	0.447
RARS2	0.445
MRPS22	0.444
SCO2	0.443
MRPS27	0.443
CLPP	0.442
TFB1M	0.441
COQ4	0.44
MRPS24	0.436
MRPL22	0.435
SFXN4	0.435
YARS2	0.434
RNMTL1	0.434
VARS2	0.433
GTPBP8	0.432
MRPL55	0.431
SLC25A3	0.431
MRPL17	0.431
ATP5SL	0.431
TUFM	0.431
C17orf89	0.43
PDE12	0.429
NDUFB4	0.428
TIMMDC1	0.427
MRPL42	0.426
GTPBP6	0.426
FOXRED1	0.426
GLRX5	0.424
MRPS33	0.424
TOMM20	0.424
NDUFV2	0.423
MRPL12	0.421
SARS2	0.42
DARS2	0.42
MRPL37	0.418
MARS2	0.415
MRPS35	0.414
MRPL20	0.414
NDUFS1	0.413
DHX30	0.413
NDUFA8	0.412
NDUFB3	0.412
MRPL39	0.41
MPV17L2	0.409
MRPL24	0.408
COX15	0.408
COX17	0.407
NDUFA5	0.406
MRPL46	0.405
HARS2	0.404
NDUFA6	0.404
POLG	0.404
MRPS23	0.4
COA6	0.4
MRPL41	0.4

Global Fraction of Cell Lines Where Essential: 217/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	10/28
bone	7/26
breast	9/33
central nervous system	12/56
cervix	3/4
colorectal	5/17
esophagus	7/13
fibroblast	0/1
gastric	4/16
kidney	4/21
liver	6/20
lung	25/75
lymphocyte	4/16
ovary	6/26
pancreas	4/24
peripheral nervous system	8/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	4/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 741
Expression level (log2 read counts): 5.03

Expression Distribution