Pfam Domains GO Terms
| WD40 |
| insulin receptor signaling pathway |
| SH3 domain binding |
| cellular response to insulin stimulus |
| response to insulin |
| cellular response to peptide hormone stimulus |
| cellular response to peptide |
| response to peptide hormone |
| nuclear speck |
| response to peptide |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| enzyme linked receptor protein signaling pathway |
| nucleolus |
| response to hormone |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cellular response to endogenous stimulus |
| RNA binding |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| TBC1D3G | 0.555 |
| PSMC1 | 0.531 |
| RRN3 | 0.531 |
| DTL | 0.53 |
| PSMD1 | 0.529 |
| TBC1D3H | 0.529 |
| TBC1D3C | 0.525 |
| MYO1H | 0.525 |
| PSMD3 | 0.517 |
| SUPT6H | 0.513 |
| CTR9 | 0.511 |
| VASN | 0.508 |
| CDC73 | 0.501 |
| SEC13 | 0.501 |
| VPS54 | 0.501 |
| CHD4 | 0.5 |
| ZFAND5 | 0.498 |
| RBM39 | 0.498 |
| C14orf93 | 0.496 |
| PSMC2 | 0.493 |
| PSMD11 | 0.49 |
| RPS12 | 0.485 |
| TICRR | 0.484 |
| PAF1 | 0.482 |
| PSMA6 | 0.481 |
| PSMC6 | 0.48 |
| FAM160A1 | 0.477 |
| TBC1D3F | 0.471 |
| COPA | 0.469 |
| ZNF655 | 0.469 |
| TOP1MT | 0.468 |
| RBBP5 | 0.468 |
| ELMOD3 | 0.468 |
| ORC1 | 0.466 |
| MYH2 | 0.464 |
| RPS2 | 0.46 |
| FBXO5 | 0.459 |
| WDR43 | 0.455 |
| HIST1H2BE | 0.455 |
| SMG7 | 0.455 |
| NOP16 | 0.455 |
| S1PR4 | 0.455 |
| SSH2 | 0.454 |
| OGFR | 0.454 |
| DNTTIP2 | 0.454 |
| PSMB4 | 0.454 |
| CDCA3 | 0.453 |
| C1QTNF9B | 0.452 |
| TBC1D3 | 0.452 |
| KIF3C | 0.45 |
| SMG1 | 0.448 |
| TBC1D3I | 0.448 |
| TBC1D3E | 0.447 |
| GOSR2 | 0.446 |
| TBC1D3K | 0.446 |
| TBC1D3L | 0.446 |
| RPS28 | 0.446 |
| AKIRIN2 | 0.445 |
| ATXN1 | 0.445 |
| TFIP11 | 0.444 |
| SNRPA1 | 0.444 |
| KPNB1 | 0.444 |
| DDTL | 0.443 |
| TWISTNB | 0.441 |
| AAMP | 0.441 |
| SF3A3 | 0.44 |
| SF3A1 | 0.439 |
| MYB | 0.439 |
| MT1E | 0.438 |
| PSAP | 0.438 |
| HIST2H2BF | 0.437 |
| BCL2L1 | 0.436 |
| PWP2 | 0.436 |
| CBWD5 | 0.435 |
| DYNC1I2 | 0.434 |
| POLA2 | 0.434 |
| NUPL1 | 0.434 |
| PSMD6 | 0.434 |
| TERF2 | 0.433 |
| WDR87 | 0.433 |
| NOL12 | 0.432 |
| UPF1 | 0.432 |
| ANKLE1 | 0.432 |
| STIL | 0.431 |
| PAN3 | 0.43 |
| CBWD3 | 0.43 |
| RAD51 | 0.429 |
| OR10G3 | 0.429 |
| RNF4 | 0.428 |
| TCEB3CL2 | 0.426 |
| LRR1 | 0.426 |
| MED12 | 0.426 |
| CCDC94 | 0.424 |
| IGFN1 | 0.424 |
| TCEB3C | 0.424 |
| RFXANK | 0.424 |
| TCEB3CL | 0.422 |
| DNM2 | 0.422 |
| CNOT1 | 0.421 |
| CDC6 | 0.419 |
| SCAF1 | 0.419 |
| SUPT5H | 0.419 |
| TRAIP | 0.418 |
| MED17 | 0.418 |
| RRM1 | 0.417 |
| CKAP5 | 0.417 |
| UBAP1 | 0.417 |
| NPIPB5 | 0.415 |
| CGB2 | 0.415 |
| CHMP2A | 0.415 |
| NBPF16 | 0.414 |
| HAP1 | 0.414 |
| INTS6 | 0.413 |
| TOPBP1 | 0.412 |
| SYT9 | 0.412 |
| SFPQ | 0.411 |
| RANBP2 | 0.411 |
| CCDC64B | 0.411 |
| RPSA | 0.41 |
| MCOLN1 | 0.409 |
| ZNF830 | 0.409 |
| GON4L | 0.409 |
| AAAS | 0.409 |
| FAM86B2 | 0.409 |
| MYO18A | 0.408 |
| NUP62 | 0.407 |
| PAN2 | 0.407 |
| PRPF8 | 0.407 |
| RPA2 | 0.407 |
| SLC4A1 | 0.407 |
| COPE | 0.407 |
| MMS22L | 0.406 |
| GOLGA6L6 | 0.406 |
| RPS9 | 0.405 |
| ORC6 | 0.405 |
| RPL30 | 0.405 |
| NOL10 | 0.405 |
| COPG1 | 0.404 |
| PSMB1 | 0.404 |
| RPL6 | 0.403 |
| PSMD7 | 0.403 |
| NBPF10 | 0.402 |
| CCDC73 | 0.401 |
| RPL14 | 0.401 |
| GNB3 | 0.4 |
| LAD1 | 0.4 |
| CCNA2 | 0.4 |
| NUP43 | 0.4 |
| ADRM1 | 0.4 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution