IK

Gene Information

Official Symbol: IK
Official Name: IK cytokine
Aliases and Previous Symbols: N/A
Entrez ID: 3550
UniProt: Q13123
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 1μM R00 exp19	-1.85
DABN 20μM R00 exp17	-1.74
Bortezomib 0.005μM R00 exp6	1.77
CCCP 1μM R00 exp11	1.86
Nocodazole 0.02μM R00 exp23	1.87
Bisphenol F 50μM R08 exp457	2.24
Thioridazine 5μM R08 exp530	2.32

Gene	Correlation
TCEB3C	0.545
CEP192	0.544
PSMB4	0.543
TFIP11	0.541
CDCA3	0.532
VPS28	0.532
GOLGA6L1	0.527
CBWD3	0.526
TCEB3CL	0.526
NSF	0.524
ATP6V1B2	0.522
SAP30BP	0.52
AATF	0.519
CHD4	0.518
TCEB3CL2	0.516
COL2A1	0.514
SUPT5H	0.513
RPL35	0.513
RPS19BP1	0.513
CBWD5	0.51
TBC1D3F	0.509
CBWD6	0.508
TBC1D3H	0.507
PRPF19	0.507
NPIPB5	0.505
TSPY8	0.504
TWISTNB	0.501
TBC1D3G	0.499
NARFL	0.499
UTP3	0.497
SNIP1	0.497
TICRR	0.496
AAMP	0.495
ATP6V1C1	0.493
PAN3	0.492
XYLT2	0.49
TP53TG3C	0.488
TP53TG3B	0.488
SLC4A1	0.488
EXOSC9	0.488
TP53TG3	0.488
CHMP4B	0.487
OSBP	0.487
CHAF1A	0.487
POLR2J3	0.486
PSMA6	0.486
PLEKHA4	0.486
LRR1	0.485
PSMD7	0.484
TBC1D3	0.484
FAM231C	0.484
FAM231A	0.484
RPS12	0.483
CDC45	0.482
ORC1	0.482
RRP7A	0.481
AKIRIN2	0.477
PAF1	0.477
VASN	0.476
KRT78	0.474
DDTL	0.473
POLE	0.472
IGFN1	0.471
PPFIA4	0.471
WAPAL	0.471
TYMS	0.471
SLC6A17	0.471
PSMB3	0.47
C14orf93	0.47
GAR1	0.469
KCTD17	0.469
C1QTNF9B	0.469
RPS7	0.469
PAN2	0.468
CCNA2	0.468
RAD51	0.467
ANKLE1	0.466
CLN6	0.466
PDCD7	0.466
FCN2	0.465
ORC6	0.464
MT1E	0.461
WDR75	0.458
AKT1S1	0.458
ZFAND5	0.457
NAALADL1	0.456
ZNF830	0.455
OR10G3	0.453
ACSF2	0.453
RRN3	0.451
DOCK6	0.45
TIMELESS	0.45
RANBP2	0.449
ANKLE2	0.449
NUPL1	0.449
RNPC3	0.448
CTAGE4	0.447
TP53TG3D	0.446
EXOSC3	0.446
PSMC2	0.445
NOL10	0.445
SNRPF	0.445
PCF11	0.444
DNTTIP2	0.444
DISP2	0.444
RAD21	0.443
AQR	0.443
CDT1	0.443
ATP6V0B	0.441
EXOSC6	0.44
CACTIN	0.44
PSMB2	0.439
RPL7L1	0.439
SMG7	0.438
POLR2D	0.438
UPF1	0.438
PNO1	0.438
NUP153	0.436
ATP6V0C	0.435
RPS19	0.435
ATP6AP2	0.435
ATP6V1A	0.434
DTL	0.434
SUPT6H	0.434
POLA2	0.433
POLR2A	0.432
GOLGA8O	0.431
RBM8A	0.43
TINF2	0.429
BYSL	0.429
CDH24	0.428
SNRNP70	0.427
SNRPA1	0.426
HIST2H3A	0.425
CDC6	0.425
POLR1A	0.425
DHX38	0.425
HIST2H3C	0.425
COPG1	0.424
MDN1	0.424
PARP3	0.423
LAD1	0.423
WDR43	0.423
RPS2	0.423
SF3A1	0.422
TBC1D3C	0.422
ADRM1	0.422
EXOSC8	0.421
HIVEP3	0.421
SMG1	0.42
MBTD1	0.419
EIF4A3	0.419
NOC4L	0.419
RPS9	0.418
RBM39	0.417
RPLP1	0.417
MTCH2	0.417
COPB1	0.417
PPIE	0.417
UBL5	0.415
FBXW9	0.415
AURKA	0.415
NIPBL	0.415
INTS5	0.415
PDCD11	0.415
MYO1H	0.415
GID4	0.415
GOLGA6A	0.415
C2orf27B	0.414
CDCA5	0.414
CDC73	0.413
INTS1	0.413
FAM25B	0.413
TUBA8	0.412
FOXD4L2	0.411
RFFL	0.411
GOLGA6L6	0.411
RRP15	0.41
SYT9	0.41
RPL6	0.409
RRS1	0.409
GOLGA6L3	0.409
CCDC94	0.409
PSMC1	0.408
CCDC116	0.408
ATP6AP1	0.408
ARCN1	0.407
EXD1	0.406
DDX56	0.406
RPL14	0.405
TBC1D3I	0.405
TBC1D3L	0.405
CCDC12	0.405
TBC1D3E	0.405
TBC1D3K	0.405
SCGB1C1	0.404
PSMD11	0.404
SH3BP1	0.404
CCDC64B	0.404
STIL	0.404
EGR2	0.403
TERF1	0.403
HIST1H2BE	0.403
CLEC11A	0.402
EXOSC5	0.402
RRM2	0.401
SF3A2	0.401
PPM1D	0.4
FAM160A1	0.4

Global Fraction of Cell Lines Where Essential: 700/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	23/26
breast	28/33
central nervous system	51/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	18/21
liver	20/20
lung	71/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1228
Expression level (log2 read counts): 6.87

Expression Distribution

RED C
RED N

protein localization to kinetochore
protein localization to chromosome, centromeric region
mitotic spindle assembly checkpoint
spindle checkpoint
mitotic spindle checkpoint
spindle assembly checkpoint
negative regulation of mitotic metaphase/anaphase transition
negative regulation of metaphase/anaphase transition of cell cycle
mitotic spindle pole
negative regulation of mitotic sister chromatid separation
negative regulation of chromosome separation
nuclear chromosome
negative regulation of mitotic sister chromatid segregation
negative regulation of sister chromatid segregation
negative regulation of chromosome segregation
negative regulation of mitotic nuclear division
negative regulation of nuclear division
U2-type precatalytic spliceosome
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
protein localization to chromosome
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
regulation of chromosome segregation
negative regulation of chromosome organization
mitotic cell cycle checkpoint
regulation of mitotic nuclear division
regulation of nuclear division
cell cycle checkpoint
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of chromosome organization
negative regulation of organelle organization