LAMTOR4

• Official Symbol: LAMTOR4
• Official Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
• Aliases and Previous Symbols: N/A
• Entrez ID: 389541
• UniProt: Q0VGL1
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 11265
• Expression level (log2 read counts): 4.98

Expression Distribution

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LAMTOR4 Expression in NALM6 Cells: 4.98