PAN3
Gene Information
- Official Symbol: PAN3
- Official Name: poly(A) specific ribonuclease subunit PAN3
- Aliases and Previous Symbols: N/A
- Entrez ID: 255967
- UniProt: Q58A45
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| PAN complex |
| positive regulation of cytoplasmic mRNA processing body assembly |
| regulation of cytoplasmic mRNA processing body assembly |
| deadenylation-dependent decapping of nuclear-transcribed mRNA |
| poly(A)-specific ribonuclease activity |
| nuclear-transcribed mRNA poly(A) tail shortening |
| RNA phosphodiester bond hydrolysis, exonucleolytic |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| positive regulation of organelle assembly |
| P-body |
| RNA phosphodiester bond hydrolysis |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| regulation of organelle assembly |
| protein kinase activity |
| RNA catabolic process |
| positive regulation of protein complex assembly |
| nucleic acid phosphodiester bond hydrolysis |
| protein targeting |
| nucleobase-containing compound catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of protein complex assembly |
| mRNA processing |
| organic cyclic compound catabolic process |
| positive regulation of cellular component biogenesis |
| positive regulation of organelle organization |
| mRNA metabolic process |
| RNA processing |
| cellular macromolecule catabolic process |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| intracellular protein transport |
| macromolecule catabolic process |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| RNA binding |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| RNA metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 7μM R03 exp135 | -1.83 |
| Rotenone 2μM R00 exp33 | -1.81 |
| Bleomycin 5μM R08 exp459 | -1.79 |
| GSK461364A 0.1μM R03 exp126 | -1.76 |
| Vitamin-D3 40μM R08 exp536 | -1.73 |
| BI-2536 0.02μM R03 exp96 | -1.72 |
| Demecolcine 0.03μM R05 exp228 | 1.71 |
| Cerivastatin 0.15μM R05 exp226 | 1.91 |
| CCCP 0.1μM R00 exp10 | 1.95 |
| MSC2530818 10μM R07 exp379 | 2.01 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PAN2 | 0.672 |
| VASN | 0.598 |
| RRM1 | 0.577 |
| CHD4 | 0.57 |
| SMG7 | 0.55 |
| DTL | 0.549 |
| PSMD11 | 0.548 |
| ZFAND5 | 0.541 |
| PSMC1 | 0.536 |
| PSMD1 | 0.534 |
| KCTD17 | 0.531 |
| SUPT6H | 0.529 |
| NARFL | 0.528 |
| PSMD3 | 0.526 |
| MT1E | 0.524 |
| COPG1 | 0.523 |
| POLE | 0.519 |
| KPNB1 | 0.517 |
| PAF1 | 0.516 |
| SMG1 | 0.514 |
| RPL35 | 0.512 |
| PSMC3 | 0.511 |
| PSMB4 | 0.507 |
| ORC1 | 0.504 |
| RAD21 | 0.502 |
| CCDC64B | 0.502 |
| COPB1 | 0.501 |
| ANKLE2 | 0.5 |
| DISP2 | 0.498 |
| IGFN1 | 0.497 |
| IK | 0.492 |
| NOP16 | 0.489 |
| SUPT5H | 0.489 |
| NUP205 | 0.488 |
| HIST2H3A | 0.487 |
| HIST2H3C | 0.487 |
| EXOSC9 | 0.487 |
| TCEB3C | 0.485 |
| LRR1 | 0.484 |
| AAMP | 0.484 |
| CDCA3 | 0.483 |
| ZNF830 | 0.483 |
| SAP30BP | 0.481 |
| COPA | 0.48 |
| C14orf93 | 0.48 |
| CCNA2 | 0.478 |
| PSMD14 | 0.478 |
| BRD2 | 0.477 |
| TSG101 | 0.477 |
| DNM2 | 0.476 |
| PSMC6 | 0.475 |
| PSMC2 | 0.474 |
| SFPQ | 0.474 |
| ARCN1 | 0.473 |
| ATXN1 | 0.472 |
| UPF1 | 0.472 |
| CTR9 | 0.471 |
| COPB2 | 0.47 |
| EXOSC3 | 0.469 |
| CBWD3 | 0.468 |
| NOL10 | 0.467 |
| C1QTNF9B | 0.466 |
| COL2A1 | 0.466 |
| TICRR | 0.466 |
| ATP13A1 | 0.466 |
| TBC1D3I | 0.465 |
| RPS19 | 0.464 |
| TBC1D3K | 0.464 |
| TBC1D3E | 0.464 |
| TBC1D3L | 0.463 |
| DDTL | 0.463 |
| SCAF1 | 0.462 |
| RPS9 | 0.461 |
| RANBP2 | 0.461 |
| GOLGA6L1 | 0.46 |
| NPIPB5 | 0.459 |
| POLA1 | 0.457 |
| ORC6 | 0.457 |
| ATP6V1B2 | 0.456 |
| SF3A1 | 0.455 |
| TCEB3CL2 | 0.454 |
| CDC73 | 0.454 |
| NUP160 | 0.454 |
| TERF2 | 0.452 |
| HIST2H3D | 0.45 |
| NUPL1 | 0.45 |
| PRIM1 | 0.45 |
| CHAF1A | 0.45 |
| COPE | 0.449 |
| TERF1 | 0.448 |
| TBC1D3 | 0.447 |
| SF3A3 | 0.447 |
| KRT2 | 0.447 |
| POLA2 | 0.445 |
| GOLGA8O | 0.445 |
| DOCK6 | 0.444 |
| PCF11 | 0.444 |
| UQCRH | 0.443 |
| SLC4A1 | 0.442 |
| XYLT2 | 0.442 |
| RAD51 | 0.442 |
| TP53TG3 | 0.441 |
| TCEB3CL | 0.441 |
| TP53TG3B | 0.441 |
| GID4 | 0.441 |
| AQR | 0.441 |
| TRAIP | 0.441 |
| SART1 | 0.441 |
| TP53TG3C | 0.44 |
| RBM39 | 0.439 |
| PSMB2 | 0.439 |
| TWISTNB | 0.439 |
| SNIP1 | 0.438 |
| SNRPA1 | 0.438 |
| TBC1D3C | 0.438 |
| PSMA6 | 0.438 |
| DHX38 | 0.437 |
| CTAGE9 | 0.437 |
| TBC1D3H | 0.436 |
| POLR2D | 0.436 |
| CBWD6 | 0.435 |
| TBC1D3G | 0.435 |
| DDX56 | 0.435 |
| CBWD5 | 0.435 |
| GPRIN2 | 0.434 |
| EBNA1BP2 | 0.433 |
| TBC1D3F | 0.433 |
| UTP3 | 0.433 |
| ZNF106 | 0.43 |
| CGB2 | 0.43 |
| MED17 | 0.429 |
| PWP2 | 0.429 |
| HIST1H2BE | 0.429 |
| PPM1D | 0.429 |
| VPS28 | 0.429 |
| TYMS | 0.428 |
| RPLP1 | 0.427 |
| SLC6A17 | 0.427 |
| SF3B3 | 0.426 |
| LAD1 | 0.425 |
| DNTTIP2 | 0.425 |
| GOLGA8J | 0.424 |
| RPL7L1 | 0.423 |
| TAF1 | 0.423 |
| TIMELESS | 0.423 |
| TAGLN | 0.422 |
| ELL | 0.422 |
| CLCN6 | 0.422 |
| SSH2 | 0.422 |
| GAR1 | 0.421 |
| CDCA5 | 0.421 |
| MYO1H | 0.421 |
| HIST1H4B | 0.42 |
| TP53TG3D | 0.42 |
| ZNF655 | 0.42 |
| WDR43 | 0.419 |
| RPA2 | 0.418 |
| PSMD2 | 0.418 |
| RPL30 | 0.418 |
| ADRM1 | 0.418 |
| GOLGA6L6 | 0.418 |
| CEP192 | 0.417 |
| CTAGE4 | 0.417 |
| SEC13 | 0.417 |
| PLK1 | 0.416 |
| PSMD8 | 0.415 |
| PARP3 | 0.415 |
| OSBP | 0.415 |
| DDT | 0.415 |
| COPZ1 | 0.415 |
| MFSD12 | 0.414 |
| HAP1 | 0.414 |
| MYLK3 | 0.414 |
| COX7A2L | 0.414 |
| PSMC4 | 0.412 |
| CLN6 | 0.412 |
| MYH7B | 0.412 |
| RPS2 | 0.411 |
| CDT1 | 0.411 |
| HIVEP3 | 0.411 |
| PSMB1 | 0.41 |
| RNPC3 | 0.41 |
| VPS54 | 0.41 |
| DDX21 | 0.41 |
| KRT78 | 0.409 |
| PIGS | 0.408 |
| EIF4A3 | 0.406 |
| PRKCZ | 0.406 |
| RPL6 | 0.405 |
| POLR2F | 0.405 |
| CLPTM1 | 0.404 |
| SH3BP1 | 0.403 |
| POLR2J3 | 0.402 |
| KIF3C | 0.401 |
| NUP85 | 0.401 |
| ISCU | 0.401 |
| EXOSC5 | 0.4 |
| ACSF2 | 0.4 |
| MED14 | 0.4 |
| ANKLE1 | 0.4 |
| CCDC116 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1888
- Expression level (log2 read counts): 6.58
Expression Distribution
PAN3 Expression in NALM6 Cells: 6.58
