PCYT1A
Gene Information
- Official Symbol: PCYT1A
- Official Name: phosphate cytidylyltransferase 1, choline, alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5130
- UniProt: P49585
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015].
- UniProt Summary: Controls phosphatidylcholine synthesis.
Pfam Domains GO Terms
Pfam Domains
| CTP transf 2 |
GO Terms
| choline-phosphate cytidylyltransferase activity |
| CDP-choline pathway |
| glycogen granule |
| phosphatidylcholine binding |
| phosphatidylcholine biosynthetic process |
| phosphatidylcholine metabolic process |
| nuclear envelope |
| ammonium ion metabolic process |
| calmodulin binding |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| phospholipid biosynthetic process |
| glycerophospholipid metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| protein homodimerization activity |
| organophosphate metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| endoplasmic reticulum |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 23/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 4/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 3/75 |
| lymphocyte | 2/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1184
- Expression level (log2 read counts): 5.54
Expression Distribution
PCYT1A Expression in NALM6 Cells: 5.54
