WDR24

Gene Information

Official Symbol: WDR24
Official Name: WD repeat domain 24
Aliases and Previous Symbols: N/A
Entrez ID: 84219
UniProt: Q96S15
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:27166823, ECO:0000269|PubMed:27487210}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
KU-0063794 3.8μM R02 exp71	-1.78
PT-1 25μM R07 exp392	-1.7
Pimelic-diphenylamide-106 5μM R00 exp28	1.72
Brefeldin A 0.02μM R00 exp8	1.75
Dinaciclib 0.007μM R07 exp355	1.76
Bleomycin 5μM R08 exp459	1.81
Vinblastine 0.015μM R05 exp208	1.85
Vinblastine 0.2μM R03 exp108	1.88
Benzoate 20000μM R08 exp456	1.9
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.93
DABN 20μM R00 exp17	1.93
THZ1 0.06μM R08 exp531	1.97
LLY-283 2.6μM R06 exp290	2
UM0125461 0.74μM R02 exp84	2.01
MLN-4924 2μM R00 exp22	2.02
MS023 7μM R03 exp135	2.02
5-Fluorouracil 20μM R00 exp2	2.06
LY2090314 0.003μM R08 exp499	2.11
Ammonium tetrathiomolybdate 10μM R08 exp448	2.12
BI-2536 0.02μM R03 exp96	2.19
Actinomycin-D 0.001μM R00 exp3	2.21
SNS-032 15μM R08 exp443	2.22
AICAR 240μM R05 exp211	2.3
Rotenone 20μM R00 exp34	2.31
Atovaquone 15μM R08 exp451	2.34
LY2090314 0.003μM R08 exp500 no dilution day6	2.43
Artemisinin 50μM R08 exp450	2.48
Aminopterin 0.005μM R07 exp335	2.66
Etoposide 0.3μM R05 exp199	2.74
UM131593 0.2μM R03 exp106	2.78
TRAIL 50ng/ml R00 exp36	2.89
Doxorubicin 0.02μM R08 exp478	2.91
TRAIL 5ng/ml R00 exp35	2.93
3-Bromopyruvate 7μM R04 exp175	3.26
MLN-4924 0.2μM R00 exp21	3.63

Gene	Correlation
RPTOR	0.787
LAMTOR4	0.724
WDR59	0.698
MIOS	0.693
MTOR	0.665
LAMTOR2	0.652
DOHH	0.646
FLCN	0.605
LAMTOR5	0.597
FNIP1	0.591
MLLT1	0.589
ZNF592	0.582
CCDC101	0.577
THG1L	0.577
RNMT	0.574
MED16	0.571
VHL	0.569
MLST8	0.564
MEAF6	0.556
MED23	0.556
FBXO11	0.556
ID3	0.555
CBFB	0.552
PMM2	0.543
LAMTOR3	0.542
GNB1L	0.538
EIF4E	0.536
TRIAP1	0.535
TLE4	0.534
TTI2	0.534
ALG1	0.531
VPS41	0.527
GMPPB	0.525
DPAGT1	0.523
UBE2G2	0.522
ENY2	0.52
UHRF1	0.519
PELO	0.517
RRAGA	0.516
TRNT1	0.512
TRIM28	0.508
NSD1	0.506
THOC6	0.505
MAPK14	0.503
SERF2	0.503
PPP2R3C	0.5
GFPT1	0.5
HARS	0.499
FAF2	0.498
DR1	0.497
AARS	0.496
TBC1D5	0.493
GTF2A2	0.492
TBP	0.492
TMEM41B	0.491
BRPF1	0.491
TTI1	0.49
BTAF1	0.488
BAK1	0.488
DHPS	0.487
CSNK2B	0.487
GTF3C2	0.485
PLAA	0.482
SEH1L	0.481
HSPD1	0.479
BAP1	0.478
GTF3C6	0.478
EIF4G1	0.477
LSMD1	0.477
CASP9	0.476
OTUD5	0.475
RTCB	0.473
ROMO1	0.468
SSBP2	0.467
ALG2	0.466
SRP14	0.465
ALG13	0.461
LAMTOR1	0.46
VDAC2	0.46
TELO2	0.457
TRMT5	0.457
ALG5	0.455
VMP1	0.455
CCT7	0.454
EXOC4	0.454
NAE1	0.454
GTF3C4	0.452
RUNX1	0.451
FGFR1OP	0.451
DAD1	0.45
MAX	0.449
ZZZ3	0.449
DPF2	0.447
EED	0.444
PAX5	0.441
UAP1	0.441
SSB	0.439
APAF1	0.438
PAM16	0.438
LSM10	0.438
ATXN10	0.436
EZH2	0.436
CBX3	0.435
VPS26A	0.435
TRMT10A	0.434
BPTF	0.432
UBA3	0.432
ORAOV1	0.431
EPRS	0.431
UBE2M	0.429
ELF2	0.428
MARCH5	0.428
CRLS1	0.428
DDOST	0.427
ATP5J	0.424
RPE	0.424
DIABLO	0.424
IRF2	0.423
LSM11	0.423
VEZT	0.42
GTF3C3	0.419
ZNF608	0.418
SLC25A26	0.418
UBE3A	0.418
HAUS8	0.417
TAZ	0.416
RPN1	0.415
MARS	0.414
MED13L	0.414
TAF5L	0.413
CYCS	0.413
USP22	0.412
TMED10	0.412
EIF3F	0.411
TEN1	0.41
OSGEP	0.409
TXNRD1	0.407
TRIP12	0.407
PPP4C	0.406
PPA2	0.406
TXNDC17	0.405
TAF6L	0.404
SMARCD1	0.404
POLR3H	0.404
ADSL	0.403
TADA1	0.403
CASP3	0.402
RPS6KB1	0.402
DNAJC3	0.401
KDSR	0.401
SRPRB	0.401
TIMM13	0.4

Global Fraction of Cell Lines Where Essential: 171/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	5/28
blood	11/28
bone	8/26
breast	9/33
central nervous system	12/56
cervix	1/4
colorectal	3/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	3/20
lung	21/75
lymphocyte	7/16
ovary	7/26
pancreas	7/24
peripheral nervous system	1/16
plasma cell	6/15
prostate	1/1
skin	1/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	11/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 645
Expression level (log2 read counts): 4.15

Expression Distribution

GATOR2 complex
positive regulation of TOR signaling
cellular response to amino acid starvation
response to amino acid starvation
regulation of TOR signaling
cellular response to starvation
response to starvation
cellular response to nutrient levels
autophagy
process utilizing autophagic mechanism
cellular response to extracellular stimulus
lysosomal membrane
regulation of autophagy
cellular response to external stimulus
response to nutrient levels
response to extracellular stimulus
regulation of cellular catabolic process
regulation of catabolic process
positive regulation of intracellular signal transduction
positive regulation of signal transduction
cellular response to stress
cellular catabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction