ZNF830

Gene Information

Official Symbol: ZNF830
Official Name: zinc finger protein 830
Aliases and Previous Symbols: N/A
Entrez ID: 91603
UniProt: Q96NB3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription. {ECO:0000250|UniProtKB:Q8R1N0}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	-2.68
Nocodazole 0.1μM R03 exp94	-2.2
Rotenone 2μM R00 exp33	-1.87
Resminostat 0.5μM R07 exp393	-1.71
Palbociclib 1μM R07 exp382	-1.7
Caffeine 2600μM R08 exp463	1.71
Disulfiram 4.3μM R06 exp281	1.85
Dimethyloxaloylglycine 100μM R05 exp229	1.87
Cycloheximide 0.02μM R00 exp14	1.88
Chloramphenicol 2μM R00 exp12	1.92
UNC1999 2μM R03 exp155	1.94
S-trityl-L-cysteine 0.5μM R05 exp243	2.08

Gene	Correlation
PSMA6	0.563
PSMB4	0.552
CHD4	0.539
TCEB3C	0.512
CHAF1A	0.509
LRR1	0.508
DNTTIP2	0.503
CDC45	0.494
COL2A1	0.492
CBWD3	0.491
NUPL1	0.489
TBC1D3F	0.488
DHX38	0.488
TSG101	0.488
ARCN1	0.488
TBC1D3H	0.486
RPS12	0.485
TCEB3CL	0.483
RFC1	0.483
PAN3	0.483
POLE	0.482
PSMC2	0.482
CTAGE4	0.481
PSMB2	0.479
CDC73	0.479
COPE	0.479
MT1E	0.478
C1QTNF9B	0.477
CBWD6	0.477
VPS28	0.477
TCEB3CL2	0.476
CCNA2	0.475
CGB2	0.474
ZFAND5	0.474
CBWD5	0.473
RANBP2	0.471
PSMD11	0.471
CACTIN	0.47
PSMC5	0.469
NUP153	0.467
TWISTNB	0.466
NSF	0.466
DDT	0.465
COPG1	0.465
MKI67IP	0.463
TICRR	0.463
OSBP	0.463
NOL10	0.462
DTL	0.462
TBC1D3G	0.462
ZNF655	0.462
PDCD11	0.461
SMG1	0.459
DDTL	0.459
NUP160	0.459
PSMD14	0.456
IK	0.455
C2orf27B	0.455
ATP6V0C	0.453
ACSF2	0.451
UPF1	0.451
NPIPB5	0.45
MED14	0.45
RPL35	0.45
ATP6V1B2	0.45
NOL8	0.449
CCDC94	0.448
CDCA3	0.448
RPS2	0.446
PWP2	0.445
AAMP	0.444
PPFIA4	0.444
PSMB3	0.444
STIL	0.443
SLC4A1	0.443
CDT1	0.443
MFSD12	0.443
CDCA5	0.442
CEP192	0.441
PAF1	0.441
PSMC1	0.44
RPS28	0.439
CMYA5	0.439
ASF1B	0.439
SH3BP1	0.437
RPS3	0.436
PSMD3	0.436
SLC6A17	0.436
UTP3	0.436
KCTD17	0.436
POLA1	0.434
TFIP11	0.434
PSMA3	0.434
GOLGA6L3	0.433
TIMELESS	0.432
TBC1D3	0.431
SAP30BP	0.431
RPL34	0.431
SEC13	0.43
PSMC6	0.43
SUPT6H	0.428
XAB2	0.428
GOLGA6L4	0.428
TOP1MT	0.427
AKIRIN2	0.427
PSMA7	0.427
TP53TG3B	0.427
TP53TG3	0.427
ATP6AP1	0.426
TP53TG3C	0.426
ANKLE2	0.425
PAN2	0.425
TRAPPC11	0.424
SART1	0.423
CNOT1	0.423
PIGS	0.423
PSMD1	0.422
PSMD2	0.422
ATP6V1C1	0.422
CCDC64B	0.421
VPS52	0.42
AQR	0.42
GOLGA8O	0.419
AKAP1	0.418
RPS19BP1	0.418
PCF11	0.418
NOP16	0.418
COPA	0.418
HIST1H2BE	0.416
PSMA1	0.415
EXOSC4	0.415
UBAP1	0.414
WDR87	0.414
S1PR4	0.413
GAR1	0.413
POLR1A	0.412
TSPY8	0.412
VASN	0.412
EXOSC5	0.412
RANGAP1	0.412
COPB2	0.411
CTAGE9	0.411
EXOSC9	0.411
AHCTF1	0.41
ZNF106	0.409
RFFL	0.409
PDCD7	0.409
RPS5	0.408
TERF1	0.408
SUPT5H	0.408
ATP6AP2	0.407
TYMS	0.406
LOC643669	0.404
TERF2	0.404
GOSR2	0.404
BYSL	0.404
C14orf93	0.404
RPL6	0.404
EXOSC3	0.404
AATF	0.404
MYH7B	0.403
GID4	0.403
COPB1	0.403
NAPA	0.402
EBNA1BP2	0.401
CCDC116	0.401
TUBA8	0.401
PSMB1	0.401
RPS9	0.4
GOLGA6A	0.4
RRP15	0.4
SF3A3	0.4

Global Fraction of Cell Lines Where Essential: 696/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	27/28
bone	25/26
breast	31/33
central nervous system	50/56
cervix	3/4
colorectal	16/17
esophagus	13/13
fibroblast	0/1
gastric	15/16
kidney	19/21
liver	18/20
lung	70/75
lymphocyte	16/16
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1401
Expression level (log2 read counts): 4.53

Expression Distribution

multi-layer follicle stage
preantral ovarian follicle growth
intestinal epithelial structure maintenance
mammalian oogenesis stage
replication fork protection
mitotic DNA replication checkpoint
DNA replication checkpoint
blastocyst growth
maintenance of gastrointestinal epithelium
negative regulation of DNA-dependent DNA replication
epithelial structure maintenance
mitotic G2/M transition checkpoint
DNA-dependent DNA replication maintenance of fidelity
negative regulation of DNA replication
ovulation cycle process
nuclear DNA replication
cell cycle DNA replication
ovarian follicle development
regulation of DNA-dependent DNA replication
ovulation cycle
digestive system process
transcription-coupled nucleotide-excision repair
oogenesis
spliceosomal complex
female gonad development
negative regulation of G2/M transition of mitotic cell cycle
development of primary female sexual characteristics
mitotic DNA damage checkpoint
blastocyst development
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
female sex differentiation
regulation of DNA replication
nucleotide-excision repair
digestion
DNA-dependent DNA replication
chromosome
female gamete generation
DNA damage checkpoint
DNA integrity checkpoint