ECSIT

Gene Information

Official Symbol: ECSIT
Official Name: ECSIT signaling integrator
Aliases and Previous Symbols: N/A
Entrez ID: 51295
UniProt: Q9BQ95
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.05
Nifuroxazide 1μM R01 exp51	-1.94
BI-D1870 3.15μM R02 exp66	1.71
Artemisinin 50μM R08 exp450	1.86
UM0125461 0.74μM R02 exp84	2.05
iCRT14 30μM R08 exp492	2.13
HMS-I2 10μM R06 exp288	2.18
Calcium Ionophore 0.4μM R07 exp342	2.23
Atovaquone 15μM R08 exp451	2.44
Hydroxyurea 100μM R07 exp329	2.47
Oligomycin-A 2μM R00 exp25	2.66

Gene	Correlation
NDUFB11	0.668
NDUFA3	0.642
NDUFB6	0.632
NDUFS2	0.625
NDUFB5	0.622
NDUFA2	0.619
GRSF1	0.612
NDUFA1	0.61
NDUFA11	0.599
NDUFAF3	0.591
MTO1	0.586
NDUFAF7	0.581
NDUFB9	0.568
C17orf89	0.566
ACAD9	0.564
NDUFA10	0.562
NUBPL	0.561
NDUFS8	0.56
NDUFA8	0.554
NDUFC2	0.552
NDUFA6	0.552
NDUFV2	0.551
NDUFAF6	0.548
NDUFB2	0.547
NDUFS7	0.546
GTPBP10	0.544
GFM1	0.531
MIPEP	0.53
RNASEH1	0.528
MCAT	0.526
NDUFB7	0.525
C12orf65	0.525
TIMMDC1	0.523
ATP5SL	0.522
MRPS16	0.521
GFM2	0.517
NDUFS5	0.517
NDUFB10	0.509
HSD17B10	0.508
MTRF1L	0.505
NDUFV1	0.504
LARS2	0.503
MALSU1	0.503
NDUFS3	0.502
FOXRED1	0.5
HMGXB3	0.498
TARS2	0.498
RPUSD3	0.498
MRPS21	0.495
IBA57	0.493
FTSJ2	0.493
MRPS5	0.492
FASTKD2	0.491
TMEM261	0.491
MTG2	0.489
RPUSD4	0.487
POLG2	0.485
EARS2	0.484
NDUFC1	0.484
CHCHD1	0.483
QRSL1	0.483
C10orf2	0.483
MRPL45	0.482
YARS2	0.481
NDUFAF5	0.479
NDUFAF1	0.478
NDUFAF4	0.476
RTN4IP1	0.475
GATC	0.474
PET117	0.474
SELRC1	0.473
AARS2	0.473
NDUFB4	0.466
NFU1	0.461
VARS2	0.46
MRPL21	0.458
MARS2	0.457
WBSCR16	0.457
COA6	0.456
NDUFS1	0.456
COQ2	0.456
COX16	0.455
GLRX5	0.454
MRPS26	0.452
MRPS6	0.451
PET112	0.45
SCO2	0.45
RBFA	0.45
POLG	0.449
MRP63	0.447
NARS2	0.445
MRPS34	0.445
MRPS33	0.444
MRPS2	0.444
NDUFA13	0.443
TRUB2	0.442
MRPL53	0.441
MRPL47	0.44
TEFM	0.44
MRPL55	0.439
SARS2	0.438
CARS2	0.436
MRPS25	0.435
GOT2	0.435
TOMM20	0.434
MRPL13	0.433
ERAL1	0.43
ISCA2	0.43
TFB1M	0.43
AIFM1	0.429
METTL17	0.427
ICT1	0.426
MRPL12	0.425
MRPL15	0.424
DAP3	0.423
FARS2	0.423
MRPL23	0.42
RNMTL1	0.42
BCS1L	0.419
MRPS12	0.419
WARS2	0.417
PTCD3	0.417
DDX28	0.417
NDUFB3	0.417
DARS2	0.416
MTG1	0.416
FASTKD5	0.413
NSUN4	0.413
SSBP1	0.412
PARS2	0.411
MTIF2	0.411
COX11	0.409
COQ4	0.409
MRPL1	0.408
COA3	0.407
MRPS35	0.407
PDSS1	0.404
SFXN4	0.402
TMEM242	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2399
Expression level (log2 read counts): 4.61

Expression Distribution