KIAA1432

Gene Information

Official Symbol: RIC1
Official Name: RIC1 homolog, RAB6A GEF complex partner 1
Aliases and Previous Symbols: N/A
Entrez ID: 57589
UniProt: Q4ADV7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-4.63
Clomiphene 4.4μM R02 exp68	-3.25
5-Fluorouracil 2μM R00 exp1	-3.24
Wortmannin 0.5μM R00 exp37	-3.24
IWR1 50μM R08 exp495	-2.91
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.83
BH1 1μM R04 exp169	-2.76
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.64
Chlorpromazine 10μM R07 exp344	-2.63
Monensin 0.3μM R08 exp507	-2.63
L-74142 5μM R03 exp131	-2.61
BI-2536 0.0042μM R03 exp95	-2.53
Q15 1 to 2μM on day4 R04 exp164	-2.48
Celastrol 0.12μM R05 exp225	-2.47
CCCP 1μM R00 exp11	-2.46
CCT251545 0.2μM R06 exp271	-2.43
Salubrinal 20μM R07 exp399	-2.42
EPZ-5676 30μM R05 exp233	-2.41
FTY720 3μM R08 exp483	-2.39
Prochlorperazine 5.2μM R02 exp77	-2.38
Mdivi-1 15μM R05 exp217	-2.35
Vemurafenib 6.6μM R02 exp89	-2.32
IU1-47 25μM R04 exp182	-2.29
Ethanol 0.003 R08 exp437	-2.28
Apcin 50 to 100μM on day4 R04 exp176	-2.27
All-trans-Retinoic-Acid 40μM R07 exp334	-2.25
Docosahexaenoic-acid 50μM R07 exp356	-2.21
Chloramphenicol 2μM R00 exp12	-2.2
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.19
JQ1 0.01μM R03 exp130	-2.19
Dimethyloxaloylglycine 100μM R05 exp229	-2.18
SB202190 10μM R03 exp148	-2.16
SGC2043 10μM R03 exp152	-2.16
Centrinone 0.5μM R07 exp343	-2.14
B02 10μM R08 exp453	-2.12
proTAME 5μM R04 exp187	-2.12
Pyrazinamide 100μM R08 exp516	-2.11
A-395N 10μM R05 exp219	-2.09
SB203580 25μM R03 exp149	-2.07
CCCP 0.1μM R00 exp10	-2.06
CVT-10216 0.1μM R06 exp278	-2.06
ETC-159 50μM R08 exp480	-2.06
Trametinib 10μM R02 exp83	-2.06
Ribavirin 10 to 15μM on day4 R04 exp160	-2.06
UM0011500 5μM R05 exp245	-2.06
Fluvastatin 2.2μM R06 exp282	-2.05
UM0125461 0.74μM R02 exp84	-2.04
Bisphenol F 50μM R08 exp457	-2
PT-1 25μM R07 exp392	-1.97
BI-6727 0.001μM R01 exp42	-1.96
CFI-400945 25μM R08 exp469	-1.95
BML-284 0.09μM R08 exp460	-1.94
Radicicol 0.16μM R05 exp242	-1.93
Wiskostatin 3μM R07 exp422	-1.93
DABN 2μM R00 exp16	-1.92
UNC1999 2μM R03 exp155	-1.92
FK-506 5μM R07 exp358	-1.9
Thioridazine 5μM R08 exp530	-1.88
FBS-Wisent 0.1 R07 exp426	-1.86
WYE-354 6μM R02 exp90	-1.86
LB-100 2μM R05 exp210	-1.84
Pifithrin-alpha 20μM R07 exp390	-1.84
Geldanamycin 0.01μM R05 exp235	-1.83
A-196 10μM R03 exp114	-1.82
A-395 10μM R05 exp218	-1.81
Myriocin 25μM R06 exp293	-1.81
UMK57 1μM R01 exp59	-1.81
Apcin 25μM plus proTAME 2μM R04 exp177	-1.8
YM155 0.0002μM R01 exp61	-1.79
39°C R06 exp303	-1.78
Alpha-Amanitin 0.5μM R00 exp5	-1.78
BVD-523 15μM R02 exp67	-1.77
Taxol 0.002μM R01 exp54	-1.76
Lapatinib 5μM R01 exp47	-1.74
QNZ 0.01μM R05 exp241	-1.72
BS-181 20μM R08 exp461	-1.71
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.71
MSC2530818 10μM R07 exp379	-1.71
Dorsomorphin 5μM R07 exp357	1.7
GSK461364A 0.1μM R03 exp126	1.8
AICAR 240μM R03 exp116	2
VER-155008 3.9μM R06 exp301	3.02

Gene	Correlation
SCAP	0.543
RGP1	0.542
MBTPS1	0.5
CEPT1	0.45
USO1	0.444
MBTPS2	0.441
UNC50	0.438
COG5	0.43
ARL1	0.428
RAB1B	0.42
GPR107	0.413
KDSR	0.41

Global Fraction of Cell Lines Where Essential: 228/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	16/28
blood	10/28
bone	6/26
breast	7/33
central nervous system	19/56
cervix	0/4
colorectal	8/17
esophagus	8/13
fibroblast	0/1
gastric	6/16
kidney	8/21
liver	4/20
lung	24/75
lymphocyte	11/16
ovary	5/26
pancreas	11/24
peripheral nervous system	2/16
plasma cell	7/15
prostate	0/1
skin	5/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	11/22
urinary tract	7/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 3346
Expression level (log2 read counts): 7.36

Expression Distribution