HMGXB3

Entrez Summary: This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trientine 500μM R08 exp534	1.7
GSK-J4 1.5μM R08 exp441	1.85
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.88
Temozolomide 200μM R04 exp189	1.89
Hydroxyurea 100μM R07 exp329	1.91
Chlorpromazine 10μM R07 exp344	1.96
Ribavirin 10μM R01 exp52	1.96
Ribavirin 10 to 15μM on day4 R04 exp160	2
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.04
Aphidicolin 0.4μM R08 exp440	2.11
Oligomycin-A 2μM R00 exp25	2.2
Etoposide 0.1μM R05 exp198	2.25
UM0125461 0.74μM R02 exp84	2.3
BI-6727 0.0125μM R03 exp97	2.33
Genistein 15μM R07 exp360	2.43
Artemisinin 50μM R08 exp450	2.5
MK-1775 0.32μM R02 exp75	2.63
Thimerosal 0.85μM R08 exp529	2.77

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular component
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific