NPRL2
Gene Information
- Official Symbol: NPRL2
- Official Name: NPR2 like, GATOR1 complex subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 10641
- UniProt: Q8WTW4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238}.
Pfam Domains GO Terms
Pfam Domains
| NPR2 |
GO Terms
| GATOR1 complex |
| cellular response to nitrogen levels |
| cellular response to nitrogen starvation |
| regulation of autophagosome assembly |
| regulation of vacuole organization |
| cellular response to amino acid starvation |
| response to amino acid starvation |
| negative regulation of TOR signaling |
| regulation of TOR signaling |
| positive regulation of autophagy |
| cellular response to starvation |
| regulation of macroautophagy |
| response to starvation |
| regulation of organelle assembly |
| cellular response to nutrient levels |
| protein kinase activity |
| negative regulation of kinase activity |
| cellular response to extracellular stimulus |
| negative regulation of transferase activity |
| GTPase activator activity |
| lysosomal membrane |
| regulation of autophagy |
| cellular response to external stimulus |
| positive regulation of cellular catabolic process |
| positive regulation of GTPase activity |
| positive regulation of catabolic process |
| negative regulation of phosphorylation |
| regulation of GTPase activity |
| response to nutrient levels |
| negative regulation of intracellular signal transduction |
| response to extracellular stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of catabolic process |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular response to stress |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12763
- Expression level (log2 read counts): 4.59
Expression Distribution
NPRL2 Expression in NALM6 Cells: 4.59
