OSGEP

Entrez Summary: N/A
UniProt Summary: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255|HAMAP-Rule:MF_03180}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Zebularine 20μM R07 exp423	-2.65
Demecolcine 0.03μM R05 exp228	-2.4
GSK626616 14μM R08 exp485	-2.2
Pifithrin-alpha 20μM R07 exp390	-2.11
Asunaprenir 3μM R07 exp336	-2.1
Cyclosporin-A 0.8μM R07 exp347	-2.07
Pyrazinamide 100μM R08 exp516	-2.04
Chloroquine 32μM R08 exp470	-2.03
SB202190 10μM R03 exp148	-1.93
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.91
Resminostat 0.5μM R07 exp393	-1.9
NMS-873 0.07μM R07 exp380	-1.89
IL-3 9ng/ml R08 exp493	-1.87
Cyclosporin-A 3μM R07 exp348	-1.86
Golgicide-A 2μM R03 exp121	-1.86
Aphidicolin 0.04μM R06 exp263	-1.84
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.84
MSC2530818 10μM R07 exp379	-1.84
Nicotinate 1000μM R03 exp140	-1.83
All-trans-Retinoic-Acid 8μM R07 exp333	-1.78
Vemurafenib 6.6μM R02 exp89	-1.77
IU1-47 25μM R04 exp182	-1.75
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.73
Rifampicin 10μM R00 exp32	-1.73
BRD2 inhibitor II 20μM R07 exp341	-1.72
5-Fluorouracil 2μM R00 exp1	-1.71
EPZ-5676 30μM R05 exp233	-1.71

Global Fraction of Cell Lines Where Essential: 719/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	24/26
breast	30/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	73/75
lymphocyte	16/16
ovary	24/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	4/5

Expression Distribution

N(6)-L-threonylcarbamoyladenine synthase activity
tRNA threonylcarbamoyladenosine modification
EKC/KEOPS complex
tRNA threonylcarbamoyladenosine metabolic process
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
nuclear speck
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression