CHKA
Gene Information
- Official Symbol: CHKA
- Official Name: choline kinase alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 1119
- UniProt: P35790
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}.
Pfam Domains GO Terms
Pfam Domains
| Choline kinase |
| APH |
| DUF227 |
GO Terms
| response to polycyclic arene |
| response to 3-methylcholanthrene |
| ethanolamine metabolic process |
| choline kinase activity |
| cholinesterase activity |
| ethanolamine kinase activity |
| choline binding |
| CDP-choline pathway |
| ethanolamine-containing compound metabolic process |
| choline metabolic process |
| primary amino compound metabolic process |
| phosphatidylethanolamine biosynthetic process |
| phosphatidylethanolamine metabolic process |
| phosphatidylcholine biosynthetic process |
| cellular biogenic amine metabolic process |
| drug binding |
| cellular amine metabolic process |
| amine metabolic process |
| phosphatidylcholine metabolic process |
| primary alcohol metabolic process |
| neurotransmitter metabolic process |
| ammonium ion metabolic process |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| phospholipid biosynthetic process |
| lipid transport |
| glycerophospholipid metabolic process |
| alcohol metabolic process |
| lipid localization |
| regulation of neurotransmitter levels |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| organic hydroxy compound metabolic process |
| response to toxic substance |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| protein homodimerization activity |
| organophosphate metabolic process |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| response to drug |
| lipid metabolic process |
| phosphorylation |
| organonitrogen compound biosynthetic process |
| ATP binding |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FLVCR1 | 0.74 |
| VKORC1L1 | 0.594 |
| CEPT1 | 0.569 |
| MBTPS1 | 0.558 |
| PCYT1A | 0.531 |
| ARPC4 | 0.504 |
| CTDNEP1 | 0.502 |
| GPR107 | 0.491 |
| ARPC2 | 0.482 |
| COG5 | 0.477 |
| SPTLC1 | 0.471 |
| MBTPS2 | 0.469 |
| SPTLC2 | 0.467 |
| MMD | 0.467 |
| GPR89A | 0.466 |
| ACTR2 | 0.459 |
| KDSR | 0.448 |
| SPTSSA | 0.438 |
| GPR89B | 0.436 |
| ARL1 | 0.431 |
| COG7 | 0.429 |
| USO1 | 0.429 |
| HTT | 0.428 |
| SCAP | 0.427 |
| COMMD5 | 0.426 |
| LSMD1 | 0.426 |
| CNEP1R1 | 0.421 |
| RGP1 | 0.421 |
| SLC5A3 | 0.417 |
| DOLK | 0.416 |
| DMXL1 | 0.411 |
| DPM3 | 0.409 |
| UNC50 | 0.408 |
| UBE2G2 | 0.406 |
| ATP2A2 | 0.404 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 10/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11902
- Expression level (log2 read counts): 5.31
Expression Distribution
CHKA Expression in NALM6 Cells: 5.31
