LSM10

Gene Information

Official Symbol: LSM10
Official Name: LSM10, U7 small nuclear RNA associated
Aliases and Previous Symbols: N/A
Entrez ID: 84967
UniProt: Q969L4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. {ECO:0000269|PubMed:16914750}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 2μM R04 exp162	-2.3
Alpha-Amanitin 0.5μM R00 exp5	-2.11
Taxol 0.002μM R01 exp54	-2.11
TNF-alpha 44ng/ml R08 exp533	-1.91
GSK2606414 1μM R05 exp236	-1.79
UM131593 0.1μM R01 exp58	-1.78
WNT3A 44ng/ml R08 exp537	-1.76
Chloramphenicol 2μM R00 exp12	-1.75
BI-6727 0.001μM R01 exp42	-1.71
SNS-032 15μM R08 exp443	1.71
TIC10 10μM R08 exp532	1.71
Olaparib 4μM R08 exp512	1.72
Tanespimycin 14μM R08 exp527	1.72
Bisphenol A 100μM R06 exp269	1.75
Centrinone 0.5μM R07 exp343	1.81
Palbociclib 1μM R07 exp382	1.96
LLY-283 2.6μM R06 exp290	2.15

Gene	Correlation
FH	0.602
DHRSX	0.578
RPIA	0.569
SLC25A26	0.565
HSD17B10	0.556
PGM3	0.554
PMM2	0.551
THG1L	0.547
TMEM242	0.546
UHRF1	0.545
SRP14	0.543
TEN1	0.542
TRMT61A	0.539
GATC	0.537
FASTKD5	0.536
SSB	0.535
BCS1L	0.535
TRIAP1	0.533
ALG1	0.533
MRPS34	0.531
AASDHPPT	0.53
PPA2	0.529
SRD5A3	0.526
DNLZ	0.523
MRPS5	0.517
PPCDC	0.516
DARS2	0.514
DOHH	0.51
ATP5J	0.509
YARS2	0.508
KCTD5	0.507
GEMIN8	0.505
SELRC1	0.504
PPP6C	0.504
DPAGT1	0.502
CHCHD4	0.499
ATXN10	0.498
UAP1	0.498
DOLK	0.495
TRMT6	0.495
MRPS16	0.494
RFT1	0.492
PARS2	0.491
PPP4C	0.491
GMPPB	0.491
MRPS6	0.49
TPK1	0.489
MRPL23	0.489
PPCS	0.488
GEMIN7	0.487
TARS2	0.487
ALG6	0.485
DAP3	0.483
MRPL21	0.481
KIAA0391	0.48
RPP21	0.479
ZCRB1	0.479
VEZT	0.478
TBCB	0.477
RPUSD4	0.477
TUFM	0.476
ATIC	0.475
PPP2R3C	0.475
MRPS14	0.473
PMVK	0.469
RARS2	0.468
TXNRD1	0.466
NARS2	0.466
ZRSR2	0.466
RBFA	0.466
EIF3F	0.462
GFM2	0.461
C15orf41	0.461
C12orf65	0.46
ALG13	0.459
SCO2	0.459
RBMX2	0.459
TSEN54	0.457
TRMT5	0.457
DDX39A	0.457
POLG	0.456
RPE	0.456
TRMT10A	0.456
COX16	0.455
RNASEH1	0.455
ATP5B	0.455
GFPT1	0.453
EARS2	0.453
GFM1	0.452
RPTOR	0.451
HCCS	0.447
MRPL53	0.447
SUPV3L1	0.442
HARS	0.44
TKT	0.44
DR1	0.44
TMEM41B	0.44
CEP57	0.439
SLC25A19	0.439
WDR24	0.438
C17orf89	0.438
ALG5	0.437
UTP23	0.436
COX17	0.432
MRPS11	0.432
ATP5D	0.432
PDSS1	0.432
ROMO1	0.432
ELP2	0.431
MRPS26	0.431
KDSR	0.43
TTC4	0.427
TAF1A	0.427
PTPMT1	0.427
GTF3C4	0.427
GTF3C6	0.426
PUS3	0.425
MRPS2	0.425
CBX3	0.424
NBN	0.423
ADSL	0.422
TUBD1	0.421
VARS2	0.421
MRPS18A	0.421
C10orf2	0.42
CYCS	0.42
URM1	0.42
ELP3	0.419
BAP1	0.419
EEF1E1	0.418
PELO	0.418
GTF2A2	0.418
QRSL1	0.418
TIMM22	0.417
RABGGTB	0.416
LAMTOR4	0.415
PIK3R4	0.414
CTC1	0.414
HARS2	0.414
OPA1	0.414
PGGT1B	0.414
MED16	0.413
N6AMT1	0.412
C1D	0.412
LSM11	0.412
CBFB	0.412
MED25	0.411
NAE1	0.41
RTCB	0.41
WDR92	0.409
ATP5A1	0.409
GEMIN6	0.409
TAZ	0.408
MRPS33	0.408
WDR59	0.407
PPA1	0.407
EXOC4	0.406
SDHA	0.406
ELAC2	0.405
MARS2	0.405
CRLS1	0.405
RNMT	0.404
PTAR1	0.403
PAXIP1	0.402
ZNHIT1	0.401
COX5A	0.401
PTDSS1	0.4

Global Fraction of Cell Lines Where Essential: 3/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3421
Expression level (log2 read counts): 4.34

Expression Distribution

U7 snRNA binding
histone pre-mRNA DCP binding
U7 snRNP
histone mRNA metabolic process
termination of RNA polymerase II transcription
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of cell cycle G1/S phase transition
Cajal body
DNA-templated transcription, termination
positive regulation of mitotic cell cycle phase transition
positive regulation of cell cycle phase transition
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of cell cycle G1/S phase transition
nuclear body
positive regulation of cell cycle process
positive regulation of cell cycle
RNA splicing
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
mRNA processing
transcription by RNA polymerase II
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
regulation of cell cycle process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression