AARS2

Gene Information

Official Symbol: AARS2
Official Name: alanyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 57505
UniProt: Q5JTZ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011].
UniProt Summary: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255|HAMAP-Rule:MF_03133}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LLY-283 2.6μM R06 exp290	1.71
Mubritinib 0.2μM R01 exp48	1.71
Rapamycin 2μM R07 exp306	1.71
Thimerosal 0.85μM R08 exp529	1.71
Calcium Ionophore 0.4μM R07 exp342	1.74
Arsenate 40μM R06 exp264	1.76
Oligomycin-A 2μM R00 exp25	1.77
Aphidicolin 0.4μM R08 exp440	1.82
UM0125461 0.74μM R02 exp84	2.16
Hydroxyurea 100μM R07 exp329	2.17

Gene	Correlation
NARS2	0.68
QRSL1	0.676
LARS2	0.669
HSD17B10	0.656
SELRC1	0.646
EARS2	0.642
TARS2	0.641
SCO2	0.633
DAP3	0.622
POLG2	0.62
GFM1	0.619
PARS2	0.615
COA3	0.615
FTSJ2	0.612
COX11	0.611
VARS2	0.611
PET112	0.61
YARS2	0.61
RARS2	0.608
MRPS34	0.607
PET117	0.606
MRPL23	0.605
MRPS26	0.597
MRPL21	0.582
MRPS21	0.582
MARS2	0.581
MRPL53	0.58
WARS2	0.577
MTG2	0.576
MRPL45	0.575
RPUSD3	0.571
GTPBP10	0.57
GFM2	0.569
DARS2	0.569
METTL17	0.568
MRPS16	0.566
FASTKD5	0.561
HARS2	0.56
RPUSD4	0.559
MRPL3	0.556
ERAL1	0.556
MTG1	0.556
MRPS14	0.555
MRPS12	0.553
COX16	0.55
MRPS6	0.55
COA6	0.544
NSUN4	0.543
WBSCR16	0.541
GATC	0.54
FARS2	0.537
MRPL4	0.535
KIAA0391	0.535
NDUFS2	0.532
NDUFB11	0.532
MRPL47	0.528
MRP63	0.525
MALSU1	0.52
MRPS24	0.518
MRPS25	0.515
MRPS27	0.513
POLRMT	0.512
RNMTL1	0.512
C10orf2	0.511
MRPS35	0.511
RBFA	0.511
MIPEP	0.508
MRPS2	0.506
TOMM20	0.506
MRPS5	0.504
BCS1L	0.501
COX20	0.501
PGM3	0.499
MRPL49	0.496
AIFM1	0.495
MTRF1L	0.495
NDUFA3	0.493
ACAD9	0.492
MRPS22	0.491
MCAT	0.489
COQ2	0.488
CARS2	0.488
TFB1M	0.487
MRPL20	0.485
MTIF2	0.485
MRPL12	0.484
MRPL39	0.483
MRPS10	0.483
COX7B	0.483
MTPAP	0.482
NDUFAF5	0.48
TEFM	0.48
MRPL2	0.479
MRPL18	0.479
MRPS9	0.477
COX15	0.477
NDUFA1	0.476
NDUFV1	0.474
ECSIT	0.473
MRPS23	0.473
MTERFD2	0.473
MRPS18A	0.472
DDX28	0.471
C12orf65	0.469
NDUFB6	0.467
MRPL37	0.467
MRPL17	0.465
TFB2M	0.465
NDUFA2	0.463
NDUFAF7	0.46
LRPPRC	0.458
POLG	0.457
NDUFC2	0.457
TRUB2	0.456
MRPL43	0.455
NDUFB9	0.454
MRPS7	0.454
CHCHD1	0.453
RNASEH1	0.453
SSBP1	0.452
DNLZ	0.449
MRPL44	0.448
MRPL15	0.446
MRPL51	0.445
SLC25A3	0.441
NDUFB7	0.44
TOMM6	0.44
MRPL33	0.439
COQ3	0.439
TMEM242	0.437
MTO1	0.436
SARS2	0.435
PNPT1	0.435
FASTKD2	0.435
XPNPEP3	0.435
MRPL42	0.431
PTCD1	0.43
HMGXB3	0.429
MTERFD1	0.429
GTPBP6	0.429
MRPS28	0.428
NDUFAF3	0.428
C1QBP	0.426
SUPV3L1	0.426
NDUFA10	0.425
METTL1	0.425
GRSF1	0.424
MRPS18B	0.422
C17orf89	0.422
TUFM	0.422
NDUFS5	0.42
ATP5SL	0.419
NDUFB5	0.419
NDUFA11	0.419
TRMT61A	0.419
MRPL55	0.418
MRPL28	0.418
TFAM	0.417
UQCC1	0.417
PTPMT1	0.416
PTCD3	0.414
UQCC2	0.414
COX6B1	0.413
MTIF3	0.412
NDUFV2	0.411
NUBPL	0.411
MRPL35	0.409
ATP5C1	0.409
IBA57	0.409
GTPBP8	0.407
COQ7	0.407
COX4I1	0.407
SCO1	0.407
MRPL52	0.406
SLC25A51	0.404
PITRM1	0.404
CLPP	0.403
HIGD2A	0.401
ICT1	0.401
NDUFB10	0.401
TIMMDC1	0.4

Global Fraction of Cell Lines Where Essential: 110/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	5/26
breast	10/33
central nervous system	2/56
cervix	1/4
colorectal	2/17
esophagus	6/13
fibroblast	0/1
gastric	2/16
kidney	4/21
liver	5/20
lung	9/75
lymphocyte	2/16
ovary	2/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	1/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	6/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1721
Expression level (log2 read counts): 6.37

Expression Distribution

tRNA SAD
tRNA-synt 2c

mitochondrial alanyl-tRNA aminoacylation
alanyl-tRNA aminoacylation
alanine-tRNA ligase activity
tRNA aminoacylation for mitochondrial protein translation
aminoacyl-tRNA editing activity
aminoacyl-tRNA metabolism involved in translational fidelity
amino acid binding
regulation of translational fidelity
mitochondrial RNA metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
tRNA modification
mitochondrial respiratory chain complex assembly
mitochondrial translation
tRNA processing
mitochondrial gene expression
RNA modification
tRNA metabolic process
cellular amino acid metabolic process
translation
ncRNA processing
peptide biosynthetic process
mitochondrion organization
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
zinc ion binding
cellular protein-containing complex assembly
RNA processing
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
protein-containing complex assembly
cellular nitrogen compound biosynthetic process