AKIRIN2

Gene Information

Official Symbol: AKIRIN2
Official Name: akirin 2
Aliases and Previous Symbols: N/A
Entrez ID: 55122
UniProt: Q53H80
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CFI-400945 25μM R08 exp469	-1.97
Benzoate 20000μM R08 exp456	-1.93
TIC10 10μM R08 exp532	-1.79
UM131593 0.2μM R03 exp106	-1.73
42°C R08 exp539	-1.7
D-Fructose 10000μM R06 exp279	1.82
Metformin 100 to 150μM on day4 R04 exp170	1.86

Gene	Correlation
TCEB3CL2	0.553
POLR2J3	0.55
TFIP11	0.548
KCTD17	0.544
LRR1	0.533
NDC1	0.527
TCEB3C	0.525
RBBP5	0.521
C14orf93	0.517
TCEB3CL	0.513
C1QTNF9B	0.508
PSMA6	0.508
SF3A3	0.503
NUPL1	0.502
DTL	0.491
ORC6	0.49
TBC1D3G	0.49
RPS28	0.488
VASN	0.488
TBC1D3H	0.485
NBPF10	0.484
MED17	0.484
ORC1	0.483
PSMD1	0.483
COPA	0.483
RPS12	0.478
IK	0.477
NUP54	0.476
HAP1	0.475
RBM39	0.475
CDCA3	0.475
CDC73	0.474
UBAP1	0.474
DDTL	0.473
CCDC94	0.471
DNTTIP2	0.47
GOLGA6A	0.47
PSMB1	0.47
RPSA	0.469
VPS54	0.467
TBC1D3C	0.467
PPFIA4	0.466
MYO18A	0.466
ISCU	0.466
PSMB4	0.465
RANBP2	0.465
RPL14	0.464
SLC4A1	0.463
ZFAND5	0.462
NPIPB5	0.462
RFFL	0.461
WDR87	0.46
SNRNP70	0.459
COPZ1	0.459
PLA2G4F	0.458
TBC1D3F	0.456
TBC1D3K	0.455
TBC1D3L	0.455
TBC1D3E	0.455
TBC1D3I	0.455
NUP43	0.454
WDR75	0.453
EXOSC5	0.453
ACD	0.453
TWISTNB	0.452
MYT1L	0.452
MYO1H	0.45
ANKLE2	0.45
HMGCR	0.449
TBC1D3	0.449
RPS2	0.448
PSMD14	0.448
RPS14	0.448
POLR2F	0.446
PLK4	0.446
PSMD11	0.446
NUFIP2	0.446
POLR1A	0.445
ZNF106	0.445
SEC13	0.445
AAAS	0.445
AHCTF1	0.444
MADCAM1	0.444
OGFR	0.442
CHD4	0.442
UTP20	0.442
PSMC2	0.442
CLN6	0.442
ANKLE1	0.441
NUP153	0.441
CACTIN	0.439
GOLGA6L3	0.439
RFXANK	0.438
SYT9	0.438
TICRR	0.438
INTS6	0.438
S1PR4	0.438
SUPT6H	0.437
NSF	0.437
NARFL	0.437
CDC45	0.436
GID4	0.435
PSMC1	0.434
PSMB2	0.434
COPG1	0.433
SMG7	0.433
CTR9	0.432
PDE4DIP	0.432
ESF1	0.43
TIMELESS	0.43
OR10G3	0.43
COPE	0.43
SNIP1	0.428
GNB3	0.428
ZNF830	0.427
ARCN1	0.427
SF3A1	0.427
NFATC4	0.427
COL2A1	0.427
SMG1	0.426
ACBD4	0.426
CDK12	0.426
INTS5	0.425
POLA2	0.424
NOP16	0.424
LIPE	0.424
SLC6A17	0.424
SCAF1	0.424
AAMP	0.423
PSMC6	0.423
CASC3	0.423
APC2	0.422
RPL6	0.422
GOLGA6L4	0.422
NBPF16	0.421
ELMOD3	0.421
MED14	0.421
GGA3	0.42
MT1E	0.42
MYLK3	0.419
TOP1MT	0.419
HIST1H2BE	0.418
PSMD3	0.418
TAF1	0.417
KIF3C	0.416
RRN3	0.416
KPNB1	0.415
TERF2	0.415
NUP205	0.415
DHX38	0.414
RPS19	0.414
ADRA1D	0.414
GOLGA6L6	0.414
RPL35	0.414
PWP2	0.413
CBWD5	0.413
TP53TG3B	0.412
ATP6V1C1	0.412
ATXN1	0.412
TP53TG3C	0.411
TP53TG3	0.411
AQR	0.411
POLE	0.411
KIAA0947	0.411
CBWD3	0.411
TERF1	0.411
APRT	0.41
RAN	0.41
CDC6	0.41
RNF113A	0.41
C2orf27B	0.41
TSPY8	0.41
MDM2	0.409
SEL1L	0.409
BYSL	0.409
NUP62	0.408
NAPA	0.408
RPS7	0.407
UTP3	0.407
CHMP4B	0.407
OTOF	0.407
SH3BP1	0.406
ACSF2	0.405
DNM2	0.405
ZNF219	0.405
RAD51	0.404
GAR1	0.404
PCF11	0.404
TRAIP	0.403
PSAP	0.403
EXOSC6	0.402
PRPF3	0.401
XYLT2	0.401
GRAMD1A	0.4
OSBP	0.4
INTS1	0.4

Global Fraction of Cell Lines Where Essential: 232/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	10/28
blood	11/28
bone	8/25
breast	12/33
central nervous system	14/56
cervix	1/4
colorectal	4/17
esophagus	3/13
fibroblast	1/1
gastric	5/15
kidney	4/21
liver	8/20
lung	20/75
lymphocyte	7/14
ovary	5/26
pancreas	5/24
peripheral nervous system	4/16
plasma cell	12/15
prostate	1/1
skin	12/24
soft tissue	2/7
thyroid	0/2
upper aerodigestive	8/22
urinary tract	12/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1590
Expression level (log2 read counts): 5.08

Expression Distribution

transcriptional repressor complex
positive regulation of interleukin-6 production
regulation of interleukin-6 production
positive regulation of endopeptidase activity
positive regulation of peptidase activity
response to lipopolysaccharide
response to molecule of bacterial origin
enzyme binding
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of cytokine production
embryo development ending in birth or egg hatching
response to bacterium
regulation of cytokine production
regulation of proteolysis
innate immune response
positive regulation of hydrolase activity
response to lipid
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
defense response to other organism
embryo development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
positive regulation of catalytic activity
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process