EXOC4

Gene Information

Official Symbol: EXOC4
Official Name: exocyst complex component 4
Aliases and Previous Symbols: N/A
Entrez ID: 60412
UniProt: Q96A65
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
THG1L	0.659
RPP21	0.614
UAP1	0.598
DOHH	0.592
RTCB	0.589
GNB1L	0.58
RPTOR	0.578
PMM2	0.573
ALG1	0.573
RNMT	0.57
GMPPB	0.568
VEZT	0.555
TRIAP1	0.555
DPAGT1	0.554
ALG13	0.548
GFPT1	0.544
ATP5J	0.544
ALG2	0.542
LSM11	0.528
EXOC3	0.526
GTF3C2	0.526
HSPD1	0.525
RPE	0.523
ATXN10	0.522
ADSL	0.52
DHPS	0.518
SRP14	0.517
NAE1	0.516
POLR3H	0.513
GTF3C4	0.513
RPN1	0.512
DDOST	0.507
GTF3C3	0.504
TSEN54	0.502
GEMIN6	0.501
TAMM41	0.498
ELP2	0.497
DDX20	0.497
GTF3C6	0.496
SSB	0.492
ALG14	0.49
EPRS	0.489
YARS	0.489
PPCS	0.489
RABGGTB	0.488
TRNT1	0.487
CCDC101	0.485
OSGEP	0.484
ELP3	0.484
EXOC5	0.483
TXNL4B	0.483
TTI2	0.482
AARS	0.48
PPA2	0.479
ORAOV1	0.478
HAUS8	0.478
MED16	0.477
PAM16	0.476
CBFB	0.474
UHRF1	0.473
ATP5O	0.472
VHL	0.47
TPRKB	0.47
GEMIN8	0.467
UBE2G2	0.466
CSNK2B	0.465
DR1	0.464
TIMM13	0.462
PPP4C	0.462
TEN1	0.462
ALG5	0.461
TAZ	0.459
ROMO1	0.458
PPP6C	0.457
URM1	0.456
WDR24	0.454
CASP9	0.452
MBTPS2	0.451
TELO2	0.45
ZRSR2	0.45
BAP1	0.448
THOC3	0.446
FH	0.446
TRMT5	0.445
PDAP1	0.443
SNAPC5	0.443
PELO	0.442
SLC25A26	0.441
TTC4	0.439
KDSR	0.438
SDHA	0.438
TSEN34	0.437
CEP57	0.437
OTUD5	0.437
MTOR	0.435
KDM8	0.435
ZBTB11	0.435
TBCB	0.434
TRIM28	0.434
CRCP	0.433
TAF1A	0.432
ABCB7	0.432
GPN2	0.431
DAD1	0.43
VRK1	0.428
TRMT10A	0.428
FAF2	0.428
PLAA	0.427
TMEM41B	0.427
TTI1	0.427
BAK1	0.426
DHRSX	0.426
DOLK	0.425
LAMTOR4	0.424
APAF1	0.423
DDX55	0.423
NSMCE1	0.423
HCCS	0.422
BCS1L	0.422
C21orf59	0.422
ATP5A1	0.422
EEF1E1	0.421
NARS	0.421
SEC62	0.421
SRP68	0.42
CCT7	0.418
DPF2	0.417
VPS41	0.416
WDR1	0.416
GEMIN7	0.416
OIP5	0.415
RFT1	0.415
DICER1	0.415
MED4	0.414
WDR59	0.413
UTP23	0.412
TBCA	0.411
ENO1	0.41
EIF4E	0.41
RNASEH2B	0.41
NAF1	0.408
ELAC2	0.407
MLLT1	0.407
CTC1	0.406
LSM10	0.406
C14orf166	0.406
POLR3B	0.405
ATP5B	0.405
UXT	0.405
MED23	0.404
WDR92	0.404
METAP2	0.404
DUSP12	0.404
GEMIN5	0.403
DDX1	0.402
CRLS1	0.401
ERCC2	0.4
NSD1	0.4
ALG6	0.4

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	2/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2326
Expression level (log2 read counts): 5.46

Expression Distribution

Screen	Score
PNU96415E 10μM R03 exp145	-2
42°C R08 exp539	1.73
SNS-032 15μM R08 exp443	2.23

vesicle tethering involved in exocytosis
myelin sheath abaxonal region
paraxial mesoderm formation
growth cone membrane
vesicle tethering
paraxial mesoderm morphogenesis
Ral GTPase binding
paraxial mesoderm development
exocyst
Flemming body
vesicle docking involved in exocytosis
mesenchyme morphogenesis
Golgi to plasma membrane transport
microvillus
vesicle docking
mesoderm formation
exocytic process
mesoderm morphogenesis
PDZ domain binding
vesicle targeting
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
protein N-terminus binding
formation of primary germ layer
mesoderm development
gastrulation
protein targeting to membrane
organelle localization by membrane tethering
regulation of macroautophagy
establishment of vesicle localization
membrane docking
vesicle localization
mesenchyme development
establishment of protein localization to membrane
synapse
regulation of autophagy
protein targeting
establishment of organelle localization
Golgi vesicle transport
anterograde trans-synaptic signaling