KIAA1432
Gene Information
- Official Symbol: RIC1
- Official Name: RIC1 homolog, RAB6A GEF complex partner 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57589
- UniProt: Q4ADV7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RIC1 |
GO Terms
| RIC1-RGP1 guanyl-nucleotide exchange factor complex |
| Rab guanyl-nucleotide exchange factor activity |
| negative regulation of cellular protein catabolic process |
| trans-Golgi network membrane |
| retrograde transport, endosome to Golgi |
| negative regulation of protein catabolic process |
| cytosolic transport |
| Rab GTPase binding |
| endosomal transport |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| negative regulation of catabolic process |
| regulation of protein catabolic process |
| positive regulation of GTPase activity |
| regulation of GTPase activity |
| protein-containing complex |
| Golgi membrane |
| positive regulation of hydrolase activity |
| regulation of cellular catabolic process |
| regulation of catabolic process |
| intracellular protein transport |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 228/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 16/28 |
| blood | 10/28 |
| bone | 6/26 |
| breast | 7/33 |
| central nervous system | 19/56 |
| cervix | 0/4 |
| colorectal | 8/17 |
| esophagus | 8/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 8/21 |
| liver | 4/20 |
| lung | 24/75 |
| lymphocyte | 11/16 |
| ovary | 5/26 |
| pancreas | 11/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 7/15 |
| prostate | 0/1 |
| skin | 5/24 |
| soft tissue | 4/9 |
| thyroid | 0/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 7/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 3346
- Expression level (log2 read counts): 7.36
Expression Distribution
KIAA1432 Expression in NALM6 Cells: 7.36
