NDUFB5

Gene Information

Official Symbol: NDUFB5
Official Name: N/ADH:ubiquinone oxidoreductase subunit B5
Aliases and Previous Symbols: N/A
Entrez ID: 4711
UniProt: O43674
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PNU96415E 10μM R03 exp145	-1.92
2-Deoxy-D-glucose 800μM R05 exp214	-1.79
Ammonium tetrathiomolybdate 10μM R08 exp448	1.72
HMS-I2 5μM R06 exp287	1.73
ONC212 0.15μM R08 exp513	1.83
Tanespimycin 14μM R08 exp527	1.83
Artemisinin 50μM R08 exp450	1.85
UM0125461 0.74μM R02 exp84	1.97
Thimerosal 0.85μM R08 exp529	1.99
Hydroxyurea 100μM R07 exp329	2.04
Bleomycin 5μM R08 exp459	2.11
Atovaquone 15μM R08 exp451	2.18
Oligomycin-A 2μM R00 exp25	2.48
HMS-I2 10μM R06 exp288	3.13

Gene	Correlation
NDUFA1	0.65
NDUFA3	0.647
C17orf89	0.644
NDUFAF7	0.638
NDUFB11	0.625
ECSIT	0.622
NDUFAF3	0.619
NDUFC2	0.618
RNASEH1	0.616
C12orf65	0.612
NDUFB6	0.601
GTPBP10	0.601
NDUFAF4	0.6
NDUFA10	0.598
NDUFA2	0.593
NDUFA11	0.59
GFM1	0.578
RTN4IP1	0.577
GRSF1	0.562
NDUFB9	0.562
MRPL21	0.562
MTRF1L	0.56
YARS2	0.554
NDUFS2	0.553
NDUFAF1	0.553
HSD17B10	0.551
ACAD9	0.546
NDUFS7	0.546
GFM2	0.544
NDUFAF6	0.541
TARS2	0.541
MRPS5	0.54
RBFA	0.535
NDUFA8	0.534
BCS1L	0.531
MRPS34	0.53
RPUSD3	0.529
FOXRED1	0.527
TMEM242	0.525
MRPS16	0.522
POLG2	0.521
MRPS21	0.52
COX16	0.519
MRPS33	0.519
NDUFB3	0.518
GATC	0.518
MRPL45	0.517
NFU1	0.517
QRSL1	0.515
POLG	0.515
COQ7	0.515
MRPL23	0.514
SELRC1	0.514
LARS2	0.513
TIMMDC1	0.513
MRPS14	0.509
NUBPL	0.508
WBSCR16	0.508
SUPV3L1	0.506
MTO1	0.506
PDSS1	0.505
MRPS6	0.505
TMEM261	0.504
ATP5SL	0.504
NDUFS8	0.503
SCO2	0.5
SLC25A26	0.499
EARS2	0.499
C10orf2	0.498
SARS2	0.497
NARS2	0.496
NDUFA6	0.494
MRPL15	0.493
MRPL53	0.492
RPUSD4	0.49
DARS2	0.489
NDUFB2	0.488
HMGXB3	0.487
SLC25A19	0.486
MTG1	0.484
ISCA2	0.48
MRPS26	0.478
IBA57	0.478
MRP63	0.476
CHCHD1	0.475
PARS2	0.474
ATP5D	0.474
NDUFAF5	0.471
MTG2	0.47
COQ2	0.468
ATP5C1	0.468
MRPL12	0.467
AIFM1	0.463
HARS2	0.463
FTSJ2	0.462
NDUFC1	0.462
TEFM	0.461
NDUFV1	0.461
TUFM	0.461
NDUFS1	0.461
MRPS11	0.46
MRPL47	0.457
VARS2	0.454
DAP3	0.454
NDUFA5	0.453
MIPEP	0.451
AASDHPPT	0.45
FASTKD5	0.448
NDUFB10	0.447
COX5A	0.447
NDUFB7	0.447
FASTKD2	0.446
GLRX5	0.446
NDUFS5	0.441
TMEM126B	0.441
CHCHD4	0.44
MRPS18A	0.44
CARS2	0.439
MRPL43	0.438
MCAT	0.437
MRPL27	0.436
PNPT1	0.436
ATP5A1	0.435
KIAA0391	0.435
MRPL20	0.434
NDUFB4	0.432
FH	0.43
MRPS9	0.429
MRPS2	0.427
MRPL44	0.425
FARS2	0.423
TPK1	0.423
NDUFS3	0.422
ATP5E	0.421
COX6C	0.421
MRPS25	0.42
AARS2	0.419
WARS2	0.419
ATP5H	0.419
COX7B	0.418
DHX30	0.417
NDUFB1	0.416
RARS2	0.416
COA6	0.416
MRPL22	0.415
ATP5B	0.415
SLC25A3	0.413
NDUFB8	0.413
PET112	0.412
UQCRC2	0.412
ATXN10	0.411
TIMM8B	0.411
TIMM21	0.41
MRPS23	0.407
COQ4	0.407
TRIAP1	0.406
POLRMT	0.405
MRPS10	0.404
TRUB2	0.403
SLC25A52	0.403
RPIA	0.401
MTPAP	0.401
MRPL36	0.401

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3513
Expression level (log2 read counts): 5.55

Expression Distribution