CRLS1

Entrez Summary: N/A
UniProt Summary: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
D-Fructose 10000μM R06 exp279	-1.82
SNS-032 15μM R08 exp443	1.7
GSK591 2.6μM R03 exp128	1.72
ML-792 0.2μM R08 exp505	1.72
Arsenate 40μM R06 exp264	1.74
BI-6727 0.04μM R03 exp98	1.77
Tanespimycin 14μM R08 exp527	1.81
BI-D1870 3.15μM R02 exp66	1.83
Rapamycin 2μM R07 exp306	1.83
5-Fluorouracil 20μM R00 exp2	1.9
CAY10603 0.55μM R08 exp467	1.91
Oligomycin-A 20μM R00 exp26	1.92
PU-H71 1μM R08 exp515	1.94
Monensin 0.3μM R08 exp507	1.95
Deferoxamine 11μM R07 exp350	1.96
Olaparib 4μM R08 exp512	1.98
Brefeldin A 0.02μM R00 exp8	2
CB-5083 0.4μM R08 exp468	2.02
Cytochalasin-B 5μM R07 exp349	2.02
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.03
Rapamycin 10μM R00 exp30	2.05
BI-6727 0.0125μM R03 exp97	2.06
Nocodazole 0.2μM R00 exp24	2.08
Pimelic-diphenylamide-106 5μM R00 exp28	2.15
Mitomycin-C 0.06μM R08 exp503	2.2
DABN 20μM R00 exp17	2.25
Etoposide 1μM R00 exp19	2.27
JQ1 0.8μM R08 exp435	2.27
LLY-283 2.6μM R06 exp290	2.27
Hippuristanol 0.12μM R08 exp488	2.33
THZ1 0.06μM R08 exp531	2.34
Aphidicolin 0.4μM R08 exp440	2.35
42°C R08 exp539	2.37
CR131-b 0.005μM R08 exp474	2.4
MLN-4924 0.2μM R00 exp21	2.44
R-DABN 8μM R03 exp111	2.45
UM131593 0.2μM R03 exp106	2.48
Rotenone 2μM R00 exp33	2.5
Milciclib 2μM R08 exp502	2.52
Doxorubicin 0.02μM R08 exp478	2.53
Staurosporine 0.02μM R08 exp524	2.54
5-Azacytidine 2μM R07 exp330	2.57
Thimerosal 0.85μM R08 exp529	2.7
Actinomycin-D 0.001μM R00 exp3	2.75
MS023 7μM R03 exp135	2.85
Rotenone 20μM R00 exp34	2.89
Dorsomorphin 5μM R07 exp357	2.9
GSK626616 14μM R08 exp485	3.04

Global Fraction of Cell Lines Where Essential: 98/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	3/28
bone	4/26
breast	6/33
central nervous system	8/56
cervix	0/4
colorectal	3/17
esophagus	3/13
fibroblast	1/1
gastric	2/16
kidney	3/21
liver	3/20
lung	11/75
lymphocyte	4/16
ovary	1/26
pancreas	6/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	1/5

Expression Distribution

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
response to phosphatidylethanolamine
cardiolipin synthase activity
2-acylglycerol-3-phosphate O-acyltransferase activity
response to L-phenylalanine derivative
response to thyroxine
cardiolipin biosynthetic process
phosphatidylglycerol biosynthetic process
cardiolipin metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
phosphatidylglycerol acyl-chain remodeling
response to thyroid hormone
phosphatidylglycerol metabolic process
response to amino acid
response to organophosphorus
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
response to acid chemical
phospholipid metabolic process
glycerolipid metabolic process
mitochondrial inner membrane
organophosphate biosynthetic process
lipid biosynthetic process
response to lipid
organophosphate metabolic process
response to hormone
response to organic cyclic compound
cellular lipid metabolic process
response to organonitrogen compound
response to drug
response to nitrogen compound
lipid metabolic process
mitochondrion
response to endogenous stimulus
response to oxygen-containing compound