GATC

Gene Information

Official Symbol: GATC
Official Name: glutamyl-tRNA amidotransferase subunit C
Aliases and Previous Symbols: N/A
Entrez ID: 283459
UniProt: O43716
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03149, ECO:0000269|PubMed:19805282}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 5μM R05 exp245	-2
2-Deoxy-D-glucose 800μM R05 exp214	-1.92
Colchicine 0.009μM R05 exp215	-1.71
Azithromycin 100μM R08 exp452	1.7
THZ1 0.06μM R08 exp531	1.75
Deferoxamine 11μM R07 exp350	1.78
Tanespimycin 14μM R08 exp527	1.78
Chloroquine 32μM R08 exp470	1.79
Genistein 15μM R07 exp360	1.88
Hinokiflavone 12μM R08 exp487	1.91
UM0125461 0.74μM R02 exp84	1.93
Hydroxyurea 100μM R07 exp329	2.03
Doxorubicin 0.02μM R08 exp478	2.04
Arsenate 40μM R06 exp264	2.1
Olaparib 4μM R08 exp512	2.15
PU-H71 1μM R08 exp515	2.18
Oligomycin-A 2μM R00 exp25	2.23
Thimerosal 0.85μM R08 exp529	2.27
TIC10 10μM R08 exp532	2.38
Rotenone 0.07μM R08 exp431	2.54
R-DABN 8μM R03 exp111	2.55

Gene	Correlation
YARS2	0.663
MRPS5	0.657
TARS2	0.636
NARS2	0.635
PARS2	0.63
HSD17B10	0.627
SELRC1	0.621
EARS2	0.616
FASTKD5	0.615
MRPL21	0.613
MRPS16	0.613
DAP3	0.612
MRPS21	0.609
QRSL1	0.607
TEFM	0.603
MRPL53	0.602
RPUSD4	0.599
MRPL23	0.597
MRPS6	0.596
GTPBP10	0.589
RNASEH1	0.588
MRPS34	0.587
RBFA	0.586
ATP5D	0.581
COX16	0.58
NDUFB11	0.578
SCO2	0.578
POLG	0.569
LARS2	0.568
VARS2	0.567
RARS2	0.563
MARS2	0.562
MRPS17	0.561
KIAA0391	0.561
GFM1	0.56
MRPS18A	0.559
DARS2	0.554
MRPL12	0.553
BCS1L	0.55
NDUFA3	0.547
POLG2	0.547
FTSJ2	0.547
PDSS1	0.547
WBSCR16	0.545
TMEM242	0.542
AARS2	0.54
NDUFAF7	0.539
LSM10	0.537
MRPL47	0.535
RPIA	0.533
MRPS14	0.531
SLC25A26	0.529
MRPS26	0.528
DNLZ	0.527
C12orf65	0.523
NDUFB5	0.518
GFM2	0.513
SARS2	0.513
MTG1	0.512
DHRSX	0.51
MRPS24	0.509
COX7B	0.509
WARS2	0.509
ATP5A1	0.508
MRP63	0.508
C10orf2	0.508
SUPV3L1	0.506
PET112	0.506
MRPS2	0.503
MRPL15	0.502
MTG2	0.501
MRPS33	0.5
TRMT61A	0.498
C17orf89	0.497
MRPS25	0.496
ATP5C1	0.495
MRPS12	0.494
MRPS35	0.492
ATP5SL	0.491
HARS2	0.49
TUFM	0.49
MRPL34	0.49
COA6	0.488
NDUFB6	0.487
RPUSD3	0.487
TMEM126B	0.482
PGM3	0.481
G6PD	0.48
COX11	0.477
MTERFD2	0.476
ECSIT	0.474
NDUFA2	0.474
PNPT1	0.474
MTRF1L	0.473
PTPMT1	0.472
MRPL45	0.47
FH	0.468
MRPL18	0.466
NDUFS7	0.466
METTL17	0.466
AIFM1	0.466
MRPS10	0.465
NDUFA1	0.463
TRUB2	0.462
MTIF3	0.46
COA3	0.459
COQ7	0.458
NDUFB9	0.458
ATP5B	0.456
ELAC2	0.456
ATP5O	0.455
MRPL3	0.455
MRPS11	0.454
PPA2	0.454
COX17	0.453
ATP5H	0.451
FARS2	0.448
TRIAP1	0.446
MIPEP	0.446
MRPS9	0.445
COX5A	0.445
TOMM20	0.444
NDUFC2	0.443
RNMTL1	0.443
TRMT10A	0.443
PMM2	0.442
TPK1	0.442
CARS2	0.441
ALG6	0.44
MRPL20	0.439
ATXN10	0.437
ATP5E	0.434
TIMM8B	0.432
THG1L	0.432
MRPL42	0.43
NDUFAF3	0.43
PET117	0.429
FAM195A	0.429
PET100	0.428
COQ3	0.428
RFT1	0.428
PMVK	0.426
RTN4IP1	0.424
NDUFB3	0.424
NDUFA10	0.423
SLC25A52	0.423
ZRSR2	0.422
MRPL4	0.421
NDUFAF4	0.42
NDUFS2	0.42
MRPL11	0.419
HMGXB3	0.417
MTPAP	0.417
UQCC2	0.417
SRD5A3	0.416
GRSF1	0.415
COQ2	0.413
MRPL2	0.412
TOMM6	0.412
MRPL55	0.411
MRPL22	0.41
MRPS23	0.41
PPCDC	0.409
MRPS7	0.408
DHX30	0.405
MRPL33	0.405
MRPL41	0.403
AASDHPPT	0.401
TOMM22	0.401
NDUFA11	0.4
TFB1M	0.4
SRP14	0.4

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3241
Expression level (log2 read counts): 6.4

Expression Distribution

glutaminyl-tRNAGln biosynthesis via transamidation
glutamyl-tRNA(Gln) amidotransferase complex
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
regulation of translational fidelity
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression