GTF3C2

Entrez Summary: N/A
UniProt Summary: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 40μM R07 exp334	-2.8
35°C R06 exp302	-2.38
Tenofovir 10μM R07 exp405	-2.1
A-769662 20μM R07 exp331	-2.06
Rapamycin 1μM R00 exp29	-2.05
Hypoxia 5%O2 R04 exp191	-1.93
IL-3 9ng/ml R08 exp493	-1.91
2-Methoxyestradiol 0.55μM R07 exp310	-1.87
Rucaparib 6.5μM R08 exp520	-1.84
JQ1 0.01μM R03 exp130	-1.82
PT-1 25μM R07 exp392	-1.76
MK2206 4μM R08 exp504	-1.75
CoCl2 18μM R07 exp346	-1.73
All-trans-Retinoic-Acid 8μM R07 exp333	-1.7
MLN-4924 2μM R00 exp22	2.3
Actinomycin-D 0.01μM R00 exp4	2.79

Global Fraction of Cell Lines Where Essential: 10/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase III general transcription initiation factor activity
5S class rRNA transcription by RNA polymerase III
transcription factor TFIIIC complex
tRNA transcription by RNA polymerase III
tRNA transcription
rRNA transcription
transcription by RNA polymerase III
ncRNA transcription
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression