TRMT61A

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)- methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Daidzin 10μM R06 exp280	-2.13
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.01
Hydroxyurea 15μM R06 exp289	-1.89
UNC2400 2μM R03 exp156	-1.79
SGC0649 7μM R03 exp150	-1.74
Doxorubicin 0.02μM R08 exp478	1.75
CB-5083 0.4μM R08 exp468	1.8
MK2206 4μM R08 exp504	1.8
Deferoxamine 11μM R07 exp350	1.82
Trientine 500μM R08 exp534	1.85
CoCl2 18μM R07 exp346	1.87
Cryptotanshinone 12μM R05 exp227	1.9
Tanespimycin 14μM R08 exp527	1.92
Pterostilbene 16μM R02 exp78	1.98
ONC212 0.15μM R08 exp513	2
Hydroxyurea 100μM R07 exp329	2.04
Sulforaphane 9μM R08 exp525	2.06
Centrinone 0.5μM R07 exp343	2.08
Thimerosal 0.85μM R08 exp529	2.12
PU-H71 1μM R08 exp515	2.2
UM131593 0.2μM R03 exp106	2.22
JQ1 0.8μM R08 exp435	2.24
BI-2536 0.02μM R03 exp96	2.3
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.33
Citral 75μM R06 exp275	2.39
LLY-283 2.6μM R06 exp290	2.39
Bisphenol A 100μM R06 exp269	2.56
Amiloride 100μM R08 exp447	2.57
Phenformin 20μM R05 exp212	2.57
Artemisinin 50μM R08 exp450	2.65
Mitomycin-C 0.06μM R08 exp503	2.8
Aphidicolin 0.4μM R08 exp440	3.18

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Methyltransf 18
GCD14

tRNA (m1A) methyltransferase complex
mRNA (adenine-N1-)-methyltransferase activity
tRNA (adenine-N1-)-methyltransferase activity
mRNA methylation
mRNA modification
tRNA methylation
RNA methylation
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
macromolecule methylation
methylation
ncRNA processing
ncRNA metabolic process
mRNA metabolic process
RNA processing
RNA metabolic process
gene expression