PGGT1B
Gene Information
- Official Symbol: PGGT1B
- Official Name: protein geranylgeranyltransferase type I subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5229
- UniProt: P53609
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}.
Pfam Domains GO Terms
Pfam Domains
| Prenyltrans |
GO Terms
| isoprenoid binding |
| CAAX-protein geranylgeranyltransferase complex |
| CAAX-protein geranylgeranyltransferase activity |
| protein geranylgeranyltransferase activity |
| negative regulation of nitric-oxide synthase biosynthetic process |
| protein geranylgeranylation |
| protein prenylation |
| prenylation |
| regulation of nitric-oxide synthase biosynthetic process |
| peptide binding |
| drug binding |
| positive regulation of cell cycle |
| zinc ion binding |
| positive regulation of cell population proliferation |
| response to cytokine |
| regulation of cell cycle |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of cell population proliferation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ALG5 | 0.541 |
| PMM2 | 0.536 |
| TAZ | 0.503 |
| AARS | 0.501 |
| GTF3C6 | 0.5 |
| TRIAP1 | 0.497 |
| SRP14 | 0.491 |
| TAMM41 | 0.489 |
| ALG1 | 0.472 |
| ATXN10 | 0.47 |
| DHRSX | 0.466 |
| SEC62 | 0.466 |
| THG1L | 0.459 |
| DPAGT1 | 0.458 |
| ALG6 | 0.455 |
| UAP1 | 0.453 |
| HARS | 0.448 |
| MRPS33 | 0.447 |
| CHCHD4 | 0.446 |
| RTCB | 0.444 |
| YARS2 | 0.441 |
| RPP21 | 0.439 |
| UHRF1 | 0.438 |
| PPA2 | 0.437 |
| GFPT1 | 0.436 |
| UBE2G2 | 0.436 |
| RNMT | 0.432 |
| GTF3C4 | 0.428 |
| PPCS | 0.425 |
| VEZT | 0.424 |
| NAE1 | 0.423 |
| ATP5A1 | 0.423 |
| SRD5A3 | 0.423 |
| GMPPB | 0.421 |
| MRPS34 | 0.419 |
| RPE | 0.419 |
| UTP23 | 0.418 |
| CRLS1 | 0.418 |
| GEMIN7 | 0.416 |
| ADSL | 0.416 |
| MED16 | 0.416 |
| TEN1 | 0.416 |
| SUPV3L1 | 0.415 |
| CBFB | 0.414 |
| LSM10 | 0.414 |
| PPP4C | 0.413 |
| ALG13 | 0.413 |
| MRPS18A | 0.412 |
| MBTPS2 | 0.41 |
| DPF2 | 0.41 |
| FH | 0.409 |
| DOLK | 0.409 |
| RPIA | 0.407 |
| MRPS6 | 0.405 |
| TIMM13 | 0.405 |
| DNLZ | 0.405 |
| TMEM41B | 0.404 |
| VARS2 | 0.404 |
| CCDC101 | 0.403 |
| TAF1A | 0.402 |
| PELO | 0.401 |
| ATP5B | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4501
- Expression level (log2 read counts): 4.83
Expression Distribution
PGGT1B Expression in NALM6 Cells: 4.83
