POLA2
Gene Information
- Official Symbol: POLA2
- Official Name: DNA polymerase alpha 2, accessory subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 23649
- UniProt: Q14181
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| DNA pol E B |
| Pol alpha B N |
GO Terms
| alpha DNA polymerase:primase complex |
| telomere maintenance via semi-conservative replication |
| DNA-directed DNA polymerase activity |
| DNA replication initiation |
| nuclear DNA replication |
| cell cycle DNA replication |
| telomere maintenance |
| telomere organization |
| DNA biosynthetic process |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| DNA-dependent DNA replication |
| DNA replication |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| anatomical structure homeostasis |
| protein heterodimerization activity |
| mitotic cell cycle process |
| mitotic cell cycle |
| DNA metabolic process |
| molecular function |
| cellular homeostasis |
| cell cycle process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| cell cycle |
| DNA binding |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ORC6 | 0.546 |
| TBC1D3G | 0.543 |
| DIDO1 | 0.532 |
| TBC1D3H | 0.526 |
| TBC1D3F | 0.521 |
| VASN | 0.516 |
| PSMB4 | 0.512 |
| CHD4 | 0.511 |
| SUPT6H | 0.509 |
| TCEB3CL2 | 0.507 |
| TRAIP | 0.507 |
| KRT78 | 0.501 |
| RPL35 | 0.501 |
| TCEB3C | 0.499 |
| HIST2H3C | 0.498 |
| HIST2H3A | 0.498 |
| PSMA6 | 0.497 |
| SMG1 | 0.497 |
| TBC1D3C | 0.492 |
| CDCA3 | 0.491 |
| HAP1 | 0.491 |
| RBBP5 | 0.491 |
| PRIM1 | 0.49 |
| CDC73 | 0.49 |
| RPS2 | 0.49 |
| PSMD11 | 0.489 |
| C14orf93 | 0.486 |
| RPS3A | 0.485 |
| RPL7A | 0.485 |
| RAD21 | 0.485 |
| WDR43 | 0.484 |
| GOLGA8O | 0.483 |
| TBC1D3 | 0.48 |
| PCF11 | 0.479 |
| UPF1 | 0.479 |
| TICRR | 0.479 |
| RPL6 | 0.478 |
| ZFAND5 | 0.477 |
| NBPF10 | 0.476 |
| SLC4A1 | 0.473 |
| TCEB3CL | 0.471 |
| SSH2 | 0.47 |
| RRP15 | 0.467 |
| CBWD3 | 0.467 |
| SF3A1 | 0.467 |
| SMG7 | 0.465 |
| ORC1 | 0.465 |
| PSMB3 | 0.462 |
| CDC45 | 0.462 |
| POLR1A | 0.461 |
| TWISTNB | 0.46 |
| POLR2J3 | 0.46 |
| RRN3 | 0.459 |
| DDX56 | 0.458 |
| DDTL | 0.458 |
| COL2A1 | 0.458 |
| NPIPB5 | 0.456 |
| TSPY1 | 0.456 |
| NARFL | 0.454 |
| MYO1H | 0.454 |
| RPS5 | 0.452 |
| TBC1D3L | 0.452 |
| TBC1D3K | 0.452 |
| TBC1D3E | 0.451 |
| GGA3 | 0.451 |
| CBWD5 | 0.451 |
| TBC1D3I | 0.451 |
| KCTD17 | 0.45 |
| AAMP | 0.45 |
| WDR75 | 0.448 |
| RPL14 | 0.448 |
| RPA2 | 0.446 |
| CCDC116 | 0.446 |
| RAD51 | 0.446 |
| DTL | 0.445 |
| PAN3 | 0.445 |
| PAF1 | 0.444 |
| PSMD1 | 0.444 |
| CWC22 | 0.444 |
| MT1E | 0.444 |
| CTAGE4 | 0.442 |
| EXOSC6 | 0.442 |
| ZNF655 | 0.44 |
| ANKLE2 | 0.439 |
| SLC6A17 | 0.439 |
| IGFN1 | 0.438 |
| C1QTNF9B | 0.437 |
| PSAP | 0.437 |
| CTR9 | 0.436 |
| RPS9 | 0.435 |
| CBWD6 | 0.435 |
| PRPF8 | 0.435 |
| ZNF106 | 0.434 |
| IK | 0.433 |
| MPHOSPH10 | 0.433 |
| SNRPA1 | 0.432 |
| PPFIA4 | 0.432 |
| CDC6 | 0.432 |
| MYB | 0.431 |
| NUPL1 | 0.431 |
| COPE | 0.429 |
| SNRNP70 | 0.429 |
| NIP7 | 0.428 |
| PSMA7 | 0.428 |
| PSMB2 | 0.428 |
| POLR2J | 0.427 |
| RPS12 | 0.427 |
| RPS7 | 0.426 |
| TFIP11 | 0.426 |
| FAM160A1 | 0.425 |
| AKIRIN2 | 0.424 |
| RPL9 | 0.424 |
| PAN2 | 0.423 |
| SSRP1 | 0.423 |
| STIL | 0.422 |
| NOL10 | 0.422 |
| POLA1 | 0.419 |
| RBM39 | 0.419 |
| PWP2 | 0.419 |
| ATP6AP1 | 0.418 |
| URB2 | 0.418 |
| NCAPG | 0.417 |
| ISCU | 0.417 |
| PSMC1 | 0.417 |
| ACSF2 | 0.417 |
| NUP160 | 0.416 |
| NHP2L1 | 0.416 |
| RNF4 | 0.415 |
| AHCTF1 | 0.415 |
| CKAP5 | 0.414 |
| CHCHD3 | 0.414 |
| RPS3 | 0.414 |
| PSMD3 | 0.414 |
| SF3A3 | 0.412 |
| CACNA1A | 0.412 |
| ELMOD3 | 0.412 |
| BRD2 | 0.412 |
| DDX47 | 0.411 |
| INTS6 | 0.411 |
| NIPBL | 0.411 |
| ATP6V1C1 | 0.411 |
| PSMC2 | 0.41 |
| RNF113A | 0.41 |
| UBL5 | 0.409 |
| PPIE | 0.409 |
| CACTIN | 0.408 |
| HIST1H2BE | 0.408 |
| RILPL2 | 0.408 |
| COPA | 0.407 |
| OGFR | 0.407 |
| SNRNP200 | 0.407 |
| TTYH1 | 0.407 |
| PSMD14 | 0.407 |
| RPS28 | 0.406 |
| RPL7L1 | 0.405 |
| BYSL | 0.405 |
| NUP133 | 0.404 |
| SCAF1 | 0.404 |
| RNF121 | 0.403 |
| UTP20 | 0.403 |
| NUP62 | 0.402 |
| SFPQ | 0.402 |
| AQR | 0.402 |
| RANBP2 | 0.402 |
| NUP43 | 0.402 |
| PSMC6 | 0.402 |
| KRT2 | 0.401 |
| NUP153 | 0.401 |
| CASC3 | 0.401 |
| COPB2 | 0.401 |
| MED17 | 0.4 |
| PSMB1 | 0.4 |
| POLE | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 410/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 17/28 |
| blood | 13/28 |
| bone | 16/26 |
| breast | 20/33 |
| central nervous system | 32/56 |
| cervix | 3/4 |
| colorectal | 15/17 |
| esophagus | 4/13 |
| fibroblast | 1/1 |
| gastric | 3/16 |
| kidney | 11/21 |
| liver | 16/20 |
| lung | 40/75 |
| lymphocyte | 9/16 |
| ovary | 16/26 |
| pancreas | 12/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 5/15 |
| prostate | 1/1 |
| skin | 7/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 14/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 334
- Expression level (log2 read counts): 6.59
Expression Distribution
POLA2 Expression in NALM6 Cells: 6.59
