MRPL45

Gene Information

Official Symbol: MRPL45
Official Name: mitochondrial ribosomal protein L45
Aliases and Previous Symbols: N/A
Entrez ID: 84311
UniProt: Q9BRJ2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	1.72
Arsenate 40μM R06 exp264	1.78
Tubacin 1.6μM R07 exp416	2.02
Hydroxyurea 100μM R07 exp329	2.14
Genistein 15μM R07 exp360	2.15
Oligomycin-A 2μM R00 exp25	2.29

Gene	Correlation
NARS2	0.665
GFM1	0.638
LARS2	0.636
HSD17B10	0.632
MRPS16	0.613
MRP63	0.612
FTSJ2	0.609
NDUFA1	0.609
QRSL1	0.605
WBSCR16	0.602
NDUFC2	0.599
MRPL53	0.598
GTPBP10	0.596
SCO2	0.595
MRPL21	0.593
PET112	0.592
MRPL20	0.592
MRPS21	0.591
MRPL47	0.589
MRPS14	0.588
MRPL23	0.583
NDUFAF7	0.581
TARS2	0.581
NDUFA3	0.577
RNMTL1	0.577
DARS2	0.577
PET117	0.576
YARS2	0.575
AARS2	0.575
MRPS26	0.574
MTG1	0.572
HMGXB3	0.571
DAP3	0.571
SELRC1	0.57
MTG2	0.57
MRPS5	0.566
CHCHD1	0.565
COX16	0.565
VARS2	0.564
RBFA	0.564
CARS2	0.559
MRPL3	0.556
PTCD3	0.554
TFB1M	0.554
EARS2	0.554
NDUFB11	0.553
COA3	0.552
MRPS34	0.55
TUFM	0.55
RTN4IP1	0.55
MRPS27	0.549
GRSF1	0.547
MARS2	0.545
PARS2	0.545
COX19	0.544
GFM2	0.542
RARS2	0.541
FASTKD5	0.537
ERAL1	0.535
MRPL12	0.535
MRPS6	0.535
METTL17	0.534
C12orf65	0.532
FASTKD2	0.528
RPUSD3	0.527
NDUFB4	0.525
MRPS9	0.525
ATP5C1	0.524
MRPS25	0.523
NDUFA11	0.522
MALSU1	0.52
NDUFS2	0.52
AIFM1	0.52
CLPP	0.52
PNPT1	0.519
NDUFB5	0.517
RPUSD4	0.517
MTRF1L	0.517
WARS2	0.515
NDUFB9	0.515
NDUFA2	0.515
MRPL42	0.514
SUPV3L1	0.513
MRPL44	0.512
SSBP1	0.512
NDUFB6	0.512
DDX28	0.512
POLG2	0.511
MTIF2	0.51
MRPL51	0.509
MRPS22	0.508
MRPL43	0.504
ATP5SL	0.503
ACAD9	0.502
COA6	0.499
HARS2	0.498
MTERFD1	0.497
MRPL49	0.496
BCS1L	0.494
MRPS7	0.494
MRPL13	0.494
COX11	0.494
C10orf2	0.487
TRUB2	0.486
MRPS33	0.485
TFAM	0.482
TEFM	0.482
ECSIT	0.482
MRPL39	0.48
MRPS23	0.476
NDUFS1	0.476
NUBPL	0.476
MTPAP	0.475
SLC25A3	0.472
MRPS28	0.472
MRPS12	0.472
MRPL48	0.472
COX7B	0.471
NDUFAF1	0.47
MRPL4	0.47
GATC	0.47
MRPL15	0.469
MIPEP	0.468
MRPL17	0.468
TIMMDC1	0.467
COX15	0.465
NDUFA5	0.464
TOMM20	0.464
POLRMT	0.462
SARS2	0.461
FOXRED1	0.461
MRPS18A	0.461
COQ2	0.461
NDUFA10	0.459
MRPS10	0.459
MRPS11	0.459
MRPL33	0.459
MRPL18	0.457
NDUFV1	0.456
MRPL38	0.455
MRPL28	0.455
MRPS24	0.455
RNASEH1	0.454
NDUFA8	0.452
PTCD1	0.449
POLG	0.449
NDUFS5	0.448
MTO1	0.448
NDUFB7	0.447
MRPS35	0.446
NDUFB3	0.446
MRPS2	0.446
MRPL1	0.445
C1QBP	0.443
NSUN4	0.443
MRPL2	0.443
TRMT10C	0.442
COX20	0.442
FARS2	0.439
MTERFD2	0.437
NDUFS7	0.437
MRPL11	0.436
TIMM8B	0.435
NDUFAF3	0.434
NDUFS3	0.433
UQCRC1	0.432
GTPBP8	0.431
SCO1	0.431
MRPL22	0.43
NDUFA13	0.427
COX17	0.427
NOA1	0.427
SLC25A26	0.427
NDUFB10	0.426
NDUFAF4	0.425
IBA57	0.425
COX7C	0.423
TIMM17A	0.422
GTPBP6	0.422
MRPS18B	0.421
TMEM261	0.421
LRPPRC	0.421
ATP5D	0.42
TOMM40	0.42
NDUFS8	0.419
COQ4	0.418
NDUFAF5	0.418
TIMM21	0.418
NDUFA6	0.418
TFB2M	0.417
NDUFAF6	0.417
TOMM6	0.415
MRPL37	0.414
ICT1	0.411
MCAT	0.41
C17orf89	0.41
MRPL55	0.41
ATP5A1	0.409
SLC25A52	0.409
HIGD2A	0.408
PDSS1	0.406
COA5	0.404
COX6B1	0.404
XPNPEP3	0.403
MRPL46	0.402
NDUFB2	0.402
COQ5	0.401
MRPS17	0.401
COQ7	0.401

Global Fraction of Cell Lines Where Essential: 82/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	6/26
breast	6/33
central nervous system	4/56
cervix	1/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	0/20
lung	14/75
lymphocyte	2/16
ovary	0/26
pancreas	5/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 631
Expression level (log2 read counts): 5.26

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression