CDCA3

Gene Information

Official Symbol: CDCA3
Official Name: cell division cycle associated 3
Aliases and Previous Symbols: N/A
Entrez ID: 83461
UniProt: Q99618
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.1μM R03 exp126	-1.94
BI-2536 0.02μM R03 exp96	-1.81
PU-H71 1μM R08 exp515	-1.75
DABN 2μM R00 exp16	1.86
BI-6727 0.001μM R01 exp42	1.88
Chloramphenicol 2μM R00 exp12	1.97
Wortmannin 0.5μM R00 exp37	2.3

Gene	Correlation
POLR2J3	0.573
TCEB3C	0.56
TICRR	0.546
TCEB3CL2	0.542
PSMD3	0.542
IK	0.532
VASN	0.53
TCEB3CL	0.526
NUPL1	0.524
PAN2	0.522
COPE	0.521
PSMD7	0.519
PSMB4	0.511
CCNA2	0.507
TFIP11	0.507
SSH2	0.507
CDC73	0.505
SUPT6H	0.501
RPS19BP1	0.501
ATP6V1C1	0.498
POLE	0.496
TBC1D3G	0.491
DDTL	0.491
POLA2	0.491
SMG7	0.49
C14orf93	0.488
PAF1	0.487
CKAP5	0.487
KRT78	0.484
MSH5	0.484
PAN3	0.483
ZFAND5	0.481
COPG1	0.48
CHD4	0.48
RPLP1	0.477
HIVEP3	0.477
TBC1D3H	0.477
AKIRIN2	0.475
TBC1D3F	0.475
AAAS	0.474
SH3BP1	0.472
MAT2A	0.471
CCDC64B	0.47
C1QTNF9B	0.47
PSMA6	0.47
SLC4A1	0.469
ATP6AP1	0.469
ORC1	0.468
DTL	0.468
RPS12	0.467
EIF4A3	0.467
SNRPA1	0.467
PSMD1	0.467
NHP2L1	0.466
NOL12	0.466
COPB1	0.464
NUP85	0.463
NARFL	0.463
NUP153	0.461
MDM2	0.461
TIMELESS	0.46
ORC6	0.458
SMG1	0.457
LRR1	0.457
CNOT1	0.455
RPS2	0.454
MT1E	0.453
ZNF106	0.453
RBM8A	0.453
TBC1D3C	0.452
NBPF16	0.452
MYH2	0.452
NUP43	0.449
ZNF830	0.448
WDR43	0.448
NDC1	0.447
AQR	0.447
TSPY8	0.446
PSMA1	0.446
RBM39	0.446
SUPT5H	0.446
CBWD3	0.445
SRFBP1	0.445
NPIPB5	0.443
RPL6	0.443
PSMD11	0.442
TYMS	0.441
HAP1	0.44
CLN6	0.44
RPS3	0.439
CBWD5	0.438
PWP2	0.437
CHAF1A	0.437
VPS28	0.436
PLEKHA4	0.436
CASC5	0.436
POLD1	0.436
PSMC6	0.436
TSG101	0.436
PSMB3	0.435
TBC1D3	0.435
WDR87	0.434
STIL	0.434
MPHOSPH10	0.433
KCTD17	0.432
UPF1	0.432
ATP13A1	0.432
CEP192	0.432
DNTTIP2	0.431
GON4L	0.431
POLR2J	0.431
PPFIA4	0.431
OGFR	0.431
PPIE	0.43
SFPQ	0.43
NUP205	0.43
PSMC4	0.429
CDC6	0.428
OSBP	0.428
NAPA	0.427
DOCK6	0.427
ATP6AP2	0.426
IGFN1	0.426
AAMP	0.426
COPA	0.426
DISP2	0.426
RAD21	0.426
PSMC1	0.425
XYLT2	0.425
UQCRH	0.424
RPL26	0.424
AHCTF1	0.424
KPNB1	0.423
PSMB2	0.423
SLC7A6OS	0.421
UBAP1	0.42
RPSA	0.42
TP53TG3D	0.42
GOLGA8O	0.42
CTR9	0.42
RRP15	0.419
GOSR2	0.418
S1PR4	0.418
TBC1D3E	0.418
TBC1D3I	0.418
TBC1D3K	0.418
TBC1D3L	0.418
RRN3	0.418
NOL10	0.417
NUP214	0.417
HIST1H2BE	0.417
COL2A1	0.417
ATP6V0C	0.415
SPECC1L	0.415
RPS7	0.415
RPS9	0.413
PNO1	0.413
RANGAP1	0.413
EXD1	0.412
CDCA5	0.412
SEC13	0.412
NUP54	0.412
EGR2	0.412
CACNA1A	0.411
MMS22L	0.41
MED29	0.41
AATF	0.409
PDCD11	0.409
LAD1	0.409
CBWD6	0.408
PSMD2	0.408
PSMB1	0.407
TRAIP	0.407
SF3A3	0.407
ITGA2B	0.406
PLK4	0.406
CHST3	0.405
RRP1	0.405
AGAP5	0.404
FAM160A1	0.404
HIST2H2BF	0.403
RPL35	0.403
PSMC2	0.403
RANBP2	0.403
RPS3A	0.403
RRP7A	0.402
POLR1A	0.402
CDH24	0.402
NUP155	0.401
PPM1D	0.401
SMC3	0.401
RPL8	0.401
RPL14	0.401
RIOK2	0.401
POLR2A	0.401
EXOSC6	0.401
RBBP5	0.4

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 719
Expression level (log2 read counts): 6.64

Expression Distribution

cell-cell adherens junction
cell division
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
cell cycle