NARFL

Gene Information

Official Symbol: CIAO3
Official Name: cytosolic iron-sulfur assembly component 3
Aliases and Previous Symbols: N/A
Entrez ID: 64428
UniProt: Q9H6Q4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bleomycin 5μM R08 exp459	-1.94
SB743921 0.001μM R05 exp244	-1.74
Thioridazine 5μM R08 exp530	1.71
proTAME 5μM R04 exp187	1.76
Tozasertib 0.1μM R07 exp414	1.78
Beta-Estradiol 0.55μM R07 exp425	1.83
UMK57 0.6μM R03 exp107	1.84
PF-06409577 20μM R07 exp389	1.86
Ethanol 0.01 R05 exp234	1.88
Rapamycin 10μM R00 exp30	1.9
Ibrutinib 10μM R08 exp442	1.94
Cadmium 60μM R08 exp462	1.95
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.96
CCCP 1μM R00 exp11	1.99
Momordin-Ic 10μM R08 exp506	2.04
Apcin 25μM plus proTAME 2μM R04 exp177	2.09
Pomalidomide 20μM R07 exp391	2.29

Gene	Correlation
POLR2J3	0.579
RBM39	0.562
PSMB4	0.556
CACTIN	0.543
VASN	0.534
CHD4	0.528
PAN3	0.528
TCEB3C	0.524
RPL35	0.523
TCEB3CL2	0.519
TCEB3CL	0.515
SMTN	0.514
MT1E	0.508
TFIP11	0.507
RAD51	0.507
IGFN1	0.503
TBC1D3F	0.502
CTR9	0.502
DTL	0.5
IK	0.499
PRPF19	0.499
TBC1D3H	0.498
TBC1D3G	0.498
CDC73	0.498
PAF1	0.497
RPS12	0.496
SF3A3	0.495
EXOSC9	0.491
RPL6	0.486
RPS2	0.484
DNM2	0.483
ORC6	0.483
DDTL	0.477
PSMD1	0.477
SNRPA1	0.476
PPM1D	0.475
COPG1	0.475
PSMA7	0.474
ORC1	0.473
RPL30	0.472
SNIP1	0.471
ATP6V1C1	0.471
TBC1D3I	0.47
TBC1D3E	0.47
KCTD17	0.47
TBC1D3K	0.469
TBC1D3L	0.469
C1QTNF9B	0.466
TBC1D3C	0.466
SH3BP1	0.463
CDCA3	0.463
NUP160	0.463
RANBP2	0.462
TSPY2	0.461
TICRR	0.461
RRP15	0.459
DISP2	0.459
TIMELESS	0.458
SNRNP70	0.456
SLC4A1	0.456
RIOK2	0.456
TBC1D3	0.455
PSMA6	0.455
SF3A1	0.454
POLE	0.454
PRPF3	0.454
POLA2	0.454
NSF	0.453
AATF	0.452
AHCTF1	0.452
AAMP	0.452
ANKLE1	0.451
NELFA	0.45
RNF113A	0.45
XYLT2	0.449
HIVEP3	0.448
DHX38	0.448
VPS54	0.447
COL2A1	0.447
INTS5	0.446
NUPL1	0.446
BRD2	0.445
POLR2A	0.444
CKAP5	0.444
RRM1	0.443
PLK1	0.443
NCL	0.443
GOLGA6L1	0.443
EXOSC6	0.442
CEP192	0.442
GAR1	0.441
DOCK6	0.441
RPL8	0.441
ATP6V1B2	0.44
INTS6	0.44
SMG7	0.44
EXD1	0.44
NAPA	0.439
SUPT5H	0.438
TP53TG3D	0.438
CBWD3	0.437
VPS28	0.437
AKIRIN2	0.437
NIP7	0.437
EXOSC3	0.437
RRN3	0.435
ZFAND5	0.434
DIDO1	0.434
LRR1	0.434
SCAF1	0.434
COPZ1	0.433
SF3A2	0.433
KIF3C	0.433
CBWD6	0.431
CBWD5	0.43
SAP30BP	0.43
UTP3	0.43
ACSF2	0.429
CCDC116	0.429
CWC22	0.428
TSG101	0.428
PSMD2	0.426
PSMB2	0.426
ATP6V1A	0.425
PSMD3	0.424
TSPY8	0.424
EXOSC5	0.423
TAF1	0.423
CDC6	0.422
SEC13	0.421
LOC643669	0.421
MTCH2	0.421
STRN	0.42
HIST1H2BE	0.42
PLA2G4F	0.419
RPS19	0.419
PPFIA4	0.418
PSMD7	0.418
ZNF655	0.418
PPIE	0.417
SMG1	0.417
NUFIP2	0.416
NOP16	0.416
CDH24	0.415
PSMC2	0.415
TP53TG3B	0.415
TP53TG3C	0.414
TP53TG3	0.414
MYB	0.413
CDT1	0.413
OGDH	0.413
USPL1	0.412
RRP7A	0.411
ARCN1	0.411
C19orf53	0.41
TSPY1	0.41
GID4	0.409
COPA	0.409
CHAF1A	0.409
RPL38	0.409
CHMP4B	0.409
RPS19BP1	0.409
TERF1	0.409
TWISTNB	0.409
ZNF574	0.409
KRT78	0.409
SF3B5	0.408
POLR2F	0.408
MBTD1	0.408
RPL7L1	0.408
TYMS	0.408
BID	0.408
AKT1S1	0.407
WDR61	0.407
GOSR2	0.407
TRAIP	0.406
COPB1	0.406
AAAS	0.406
PDS5B	0.406
NAALADL1	0.405
PSMC1	0.405
FAM160A1	0.405
C14orf93	0.405
RPP40	0.405
OSBP	0.404
FCN2	0.404
SUPT6H	0.404
TPX2	0.404
ATXN1	0.404
PWP2	0.404
TERF2	0.404
NPIPB11	0.403
POLR2L	0.403
CEBPZ	0.403
DIMT1	0.403
CDC45	0.403
SSH2	0.402
WDR87	0.402
DDT	0.402
DGCR14	0.402
SYT9	0.401
FAM25B	0.4
DIEXF	0.4
AQR	0.4

Global Fraction of Cell Lines Where Essential: 735/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 368
Expression level (log2 read counts): 6.24

Expression Distribution

Fe hyd SSU
Fe hyd lg C

CIA complex
oxygen homeostasis
gas homeostasis
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
4 iron, 4 sulfur cluster binding
hematopoietic progenitor cell differentiation
cofactor biosynthetic process
response to hypoxia
response to decreased oxygen levels
sulfur compound metabolic process
response to oxygen levels
cofactor metabolic process
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
chemical homeostasis
response to abiotic stimulus
homeostatic process