RBBP5

Gene Information

Official Symbol: RBBP5
Official Name: RB binding protein 5, histone lysine methyltransferase complex subunit
Aliases and Previous Symbols: N/A
Entrez ID: 5929
UniProt: Q15291
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:19556245}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
TBC1D3G	0.554
TBC1D3C	0.547
RPS5	0.545
C14orf93	0.543
TBC1D3H	0.542
PSMB4	0.536
RPS2	0.524
AKIRIN2	0.521
RPS28	0.517
TBC1D3L	0.517
TBC1D3E	0.516
TBC1D3I	0.516
TBC1D3K	0.516
RPS12	0.514
TCEB3CL2	0.511
POLA1	0.51
CBWD5	0.509
PWP2	0.502
CBWD3	0.501
TBC1D3F	0.497
KCTD17	0.493
POLA2	0.491
SEC13	0.491
DDTL	0.488
BYSL	0.486
CDC73	0.486
MED17	0.483
TRIM52	0.483
VASN	0.482
RPL35	0.48
TBC1D3	0.479
TCEB3C	0.477
NOP16	0.477
RPL6	0.476
ISCU	0.476
PSMA6	0.475
NPIPB5	0.475
OR10G3	0.474
RPL38	0.473
TCEB3CL	0.472
COPG1	0.472
SSH2	0.472
NUP160	0.471
TFIP11	0.47
SF3A1	0.47
ZNF106	0.468
CBWD6	0.467
RPS19	0.467
HIST2H3A	0.466
HIST2H3C	0.465
DTL	0.462
GGA3	0.462
UTP20	0.462
WDR87	0.46
CHD4	0.459
HAP1	0.459
AQR	0.458
DISP2	0.457
RPS7	0.456
SLC4A1	0.456
ATP6V0B	0.455
NBPF10	0.454
C1QTNF9B	0.454
PSMD11	0.454
PSMD1	0.452
ORC1	0.451
RANBP2	0.45
STIL	0.449
SYT9	0.447
OGFR	0.446
RBM39	0.444
MYH2	0.444
FAM160A1	0.443
S1PR4	0.441
GOLGA6L3	0.441
TWISTNB	0.44
PSMB1	0.44
EBNA1BP2	0.44
TSPY8	0.44
NOP14	0.439
C3	0.439
COPA	0.439
RPL30	0.438
MYO1H	0.437
CCNA2	0.437
SUPT5H	0.437
CKAP5	0.437
RFFL	0.437
CACTIN	0.437
TP53TG3B	0.436
TP53TG3	0.435
TP53TG3C	0.434
NUP133	0.434
PSMC2	0.434
NUPL1	0.434
PSMD14	0.433
ZFAND5	0.433
PSMD6	0.432
UTP3	0.431
RRN3	0.43
FAM25B	0.43
RPS20	0.43
RPS11	0.429
EXOSC5	0.428
RAD21	0.427
FBXO5	0.426
ATP6AP1	0.426
PDE4DIP	0.426
MCOLN1	0.425
HIVEP3	0.425
AAMP	0.424
TICRR	0.424
MT1E	0.424
PPAN	0.424
MYT1L	0.424
CDC45	0.423
KIF3C	0.423
XAB2	0.422
PSAP	0.422
HIST2H2BF	0.422
POLR2F	0.421
MYO18A	0.421
SUPT6H	0.421
SLC38A7	0.421
SNRPA1	0.419
MED14	0.418
GOLGA8O	0.418
DDX56	0.416
MYB	0.416
ORC6	0.416
TAGLN	0.416
GOLGA6L4	0.415
NUP107	0.414
PSMA1	0.414
SLC6A17	0.414
UPF1	0.412
OR11H6	0.412
PSMC6	0.412
NPIPB8	0.409
WDR46	0.408
SRRM2	0.408
APRT	0.407
DDT	0.407
CHCHD3	0.407
COPZ1	0.406
NAPA	0.406
NBPF16	0.406
SNRNP70	0.405
MDM2	0.405
LAD1	0.404
KRT78	0.404
GOSR2	0.404
RPSA	0.404
PALB2	0.404
SF3A3	0.404
CGB2	0.404
SFPQ	0.403
TP53TG3D	0.403
PSMB3	0.402
RRP15	0.402
TOP1MT	0.402
IGFN1	0.402
NUP43	0.401
EGR2	0.401
RIOK2	0.4
CDCA3	0.4
RNF113A	0.4
CNOT1	0.4

Global Fraction of Cell Lines Where Essential: 643/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	26/28
bone	22/25
breast	27/33
central nervous system	50/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	13/15
kidney	14/21
liver	20/20
lung	71/75
lymphocyte	11/14
ovary	20/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	10/15
prostate	1/1
skin	22/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	21/22
urinary tract	25/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1065
Expression level (log2 read counts): 5.81

Expression Distribution

Screen	Score
GSK-J4 1.5μM R08 exp441	-1.85
ONC212 0.15μM R08 exp513	-1.8
Golgicide-A 4μM R03 exp122	2.41

Set1C/COMPASS complex
MLL3/4 complex
histone methyltransferase activity (H3-K4 specific)
beta-catenin-TCF complex assembly
MLL1 complex
histone H3-K4 methylation
histone methyltransferase complex
regulation of megakaryocyte differentiation
methylated histone binding
histone lysine methylation
response to estrogen
peptidyl-lysine methylation
histone methylation
protein methylation
protein alkylation
transcription regulatory region DNA binding
regulation of myeloid cell differentiation
macromolecule methylation
methylation
peptidyl-lysine modification
post-translational protein modification
histone modification
covalent chromatin modification
regulation of hemopoiesis
chromatin organization
cellular response to DNA damage stimulus
nucleolus
peptidyl-amino acid modification
chromosome organization
protein-containing complex assembly
regulation of immune system process
cellular response to stress
regulation of cell differentiation
protein-containing complex subunit organization