ATP5A1

Gene Information

Official Symbol: ATP5F1A
Official Name: ATP synthase F1 subunit alpha
Aliases and Previous Symbols: N/A
Entrez ID: 498
UniProt: P25705
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM R07 exp318	-2.15
Dihydrosphingosine 8μM R08 exp476	-1.84
Adefovir 20μM R07 exp332	-1.78
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.75
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.71
Olaparib 4μM R08 exp512	1.7
Mubritinib 0.2μM R02 exp65	1.71
Trientine 500μM R08 exp534	1.71
Hydroxyurea 100μM R07 exp329	1.78
Actinomycin-D 0.001μM R00 exp3	1.81
MS023 7μM R03 exp135	1.81
AICAR 240μM R05 exp211	1.85
Arsenate 40μM R06 exp264	1.86
Nocodazole 0.1μM R03 exp94	1.86
CB-5083 0.4μM R08 exp468	1.87
iCRT14 30μM R08 exp492	1.94
PU-H71 1μM R08 exp515	2.02
Etoposide 0.3μM R05 exp199	2.17
Pimelic-diphenylamide-106 5μM R00 exp28	2.18
NMS-873 0.07μM R07 exp380	2.19
CI-1040 9.5μM R08 exp472	2.2
LLY-283 2.6μM R06 exp290	2.27
Aphidicolin 0.4μM R08 exp440	2.29
Mitomycin-C 0.06μM R08 exp503	2.32
42°C R08 exp539	2.36
SNS-032 25μM R07 exp401	2.44
QNZ 0.01μM R05 exp241	2.45
Phenformin 20μM R05 exp212	2.48
GSK-J4 1.5μM R08 exp441	2.5
Chloramphenicol 20μM R00 exp13	2.61
Oligomycin-A 2μM R00 exp25	2.62
Mubritinib 0.2μM R01 exp48	2.67
Ammonium tetrathiomolybdate 10μM R08 exp448	2.68
Bleomycin 5μM R08 exp459	2.74
Hippuristanol 0.12μM R08 exp488	2.79
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.8
QNZ 0.01μM R08 exp439	2.81
UM131593 0.2μM R03 exp106	2.89
Doxorubicin 0.02μM R08 exp478	3.06
Atovaquone 15μM R08 exp451	3.35
Rotenone 0.07μM R08 exp431	3.48
Citral 75μM R06 exp275	3.69

Gene	Correlation
ATP5B	0.782
ATP5D	0.776
ATP5O	0.764
ATP5C1	0.693
ATP5L	0.644
SUPV3L1	0.586
ATP5H	0.582
ATP5F1	0.581
HSD17B10	0.579
MRPL21	0.578
YARS2	0.571
ATP5J	0.571
BCS1L	0.568
WBSCR16	0.565
ATP5E	0.562
TMEM242	0.561
MRPS14	0.56
TRIAP1	0.555
PPA2	0.55
ATP5J2	0.549
DAP3	0.548
UBE2G2	0.54
SLC25A26	0.538
ATP5I	0.537
PARS2	0.533
OPA1	0.532
DOHH	0.529
FH	0.527
MRPS6	0.526
ROMO1	0.526
COX16	0.522
TAZ	0.518
MRPL23	0.516
PNPT1	0.516
SCO2	0.514
DARS2	0.514
HSPD1	0.513
TARS2	0.509
GATC	0.508
MRPS11	0.505
MRP63	0.504
MRPS26	0.503
MRPL47	0.503
THG1L	0.502
PMM2	0.5
UAP1	0.499
GFM1	0.499
MRPS21	0.499
MRPS16	0.497
HCCS	0.494
MBTPS2	0.491
ALG6	0.491
TEFM	0.491
DNLZ	0.49
SELRC1	0.484
VARS2	0.484
TAMM41	0.483
ALG5	0.483
DHRSX	0.483
COX7B	0.482
HARS2	0.478
ATXN10	0.478
ELAC2	0.477
UQCRC2	0.477
FASTKD5	0.474
ADSL	0.474
NDUFAF4	0.473
CYCS	0.471
SSB	0.47
KIAA0391	0.47
RARS2	0.47
PGM3	0.47
GFPT1	0.468
UBA5	0.467
MRPS18A	0.467
SLC25A3	0.464
NDUFA3	0.464
TMEM41B	0.463
TUFM	0.462
MRPS34	0.461
SARS2	0.46
NARS2	0.456
PGS1	0.455
EARS2	0.454
C10orf2	0.454
DPAGT1	0.453
KDSR	0.453
CASP9	0.452
NDUFC2	0.451
PDSS1	0.45
MRPS23	0.45
MRPL20	0.449
MRPL53	0.448
MRPS5	0.447
GTF3C6	0.446
C17orf89	0.446
CBFB	0.445
QRSL1	0.444
ENY2	0.443
CEPT1	0.442
URM1	0.442
COX15	0.442
RPP21	0.441
CRLS1	0.44
FAF2	0.44
HIST1H2BK	0.439
RBFA	0.438
LARS2	0.437
GTPBP10	0.436
NDUFB5	0.435
ALG1	0.435
SEC62	0.433
C14orf2	0.433
NDUFB1	0.431
MRPS33	0.431
MRPL15	0.43
APAF1	0.43
SLC25A52	0.429
VEZT	0.428
MRPS10	0.425
MRPL41	0.425
SDHA	0.425
NDUFAF7	0.424
NDUFB3	0.424
MTRF1L	0.424
PLAA	0.424
PGGT1B	0.423
RTN4IP1	0.423
PPCS	0.423
NDUFA1	0.423
RPE	0.422
NDUFB11	0.422
C1orf27	0.422
EXOC4	0.422
MRPS9	0.421
DOLK	0.421
RPUSD4	0.421
TIMM13	0.421
ELP3	0.42
BAK1	0.42
DNAJC3	0.419
LSM11	0.419
MRPS25	0.417
MARS2	0.416
PPP6C	0.416
GMPPB	0.414
TRNT1	0.413
SRP14	0.411
RPTOR	0.411
EIF3F	0.41
FTSJ2	0.41
MRPS2	0.409
MRPL45	0.409
TRMT10A	0.409
LSM10	0.409
RNMT	0.406
GFM2	0.405
ALG13	0.405
RNASEH1	0.403
NDUFV1	0.402
RTCB	0.402
C12orf65	0.401
RPIA	0.401
TRUB2	0.4
COQ3	0.4
TMED10	0.4

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 648
Expression level (log2 read counts): 9.1

Expression Distribution

ATP-synt ab
ATP-synt ab C
ATP-synt ab N

proton-transporting ATP synthase complex
angiostatin binding
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
mitochondrial proton-transporting ATP synthase complex
proton-transporting ATP synthase activity, rotational mechanism
MHC class I protein binding
mitochondrial ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP synthesis coupled proton transport
cristae formation
ATP biosynthetic process
COP9 signalosome
negative regulation of endothelial cell proliferation
ADP binding
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
positive regulation of blood vessel endothelial cell migration
purine ribonucleoside triphosphate metabolic process
transmembrane transporter activity
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
regulation of blood vessel endothelial cell migration
mitochondrial transmembrane transport
nucleoside triphosphate metabolic process
positive regulation of endothelial cell migration
oxidative phosphorylation
negative regulation of epithelial cell proliferation
mitochondrial membrane organization
regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
proton transmembrane transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
regulation of endothelial cell migration
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process