DDX28

Entrez Summary: N/A
UniProt Summary: Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LLY-283 2.6μM R06 exp290	1.71
Docosahexaenoic-acid 50μM R07 exp356	1.77
Mubritinib 0.2μM R02 exp65	1.81
Hydroxyurea 100μM R07 exp329	1.85
Pterostilbene 16μM R02 exp78	1.87
Vemurafenib 6.6μM R02 exp89	1.88
UM0125461 0.74μM R02 exp84	1.99
Oligomycin-A 2μM R00 exp25	2.44

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Helicase C
DEAD

mitochondrial ribosomal large subunit rRNA binding
mitochondrial large ribosomal subunit assembly
mitochondrial ribosome assembly
ribonucleoprotein granule
ribosomal large subunit assembly
rRNA binding
mitochondrial nucleoid
RNA helicase activity
ribosome assembly
ribosomal large subunit biogenesis
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
ribonucleoprotein complex biogenesis
organelle assembly
cellular protein-containing complex assembly
nucleolus
mitochondrion
RNA binding
ATP binding
protein-containing complex assembly
protein-containing complex subunit organization