MTG1

Gene Information

Official Symbol: MTG1
Official Name: mitochondrial ribosome associated GTPase 1
Aliases and Previous Symbols: N/A
Entrez ID: 92170
UniProt: Q9BT17
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. {ECO:0000269|PubMed:23396448}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcium Ionophore 0.4μM R07 exp342	1.71
UM0125461 0.74μM R02 exp84	1.76
Quercetin 20μM R08 exp517	1.77
LY2090314 0.003μM R08 exp499	1.82
ONC212 0.15μM R08 exp513	1.83
Arsenate 40μM R06 exp264	1.86
Artemisinin 50μM R08 exp450	1.96
Oligomycin-A 2μM R00 exp25	1.96
Trientine 500μM R08 exp534	1.99
NMS-873 0.07μM R07 exp380	2.12
Deferoxamine 11μM R07 exp350	2.14
Tubacin 1.6μM R07 exp416	2.14
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.23
Hydroxyurea 100μM R07 exp329	2.25
Genistein 15μM R07 exp360	2.67

Gene	Correlation
GTPBP10	0.612
QRSL1	0.603
MRPL23	0.597
PET112	0.596
MRPL21	0.596
NDUFA3	0.581
MRPS5	0.578
CHCHD1	0.577
GFM2	0.574
MRPL45	0.572
NDUFB11	0.572
TARS2	0.57
NARS2	0.562
MRPS34	0.562
MRPS21	0.559
SELRC1	0.558
FASTKD5	0.556
AARS2	0.556
WBSCR16	0.555
RBFA	0.553
YARS2	0.551
FTSJ2	0.551
IBA57	0.551
MRPL53	0.549
MIPEP	0.549
HSD17B10	0.542
MRPS35	0.542
METTL17	0.539
EARS2	0.539
MTG2	0.537
RARS2	0.536
PARS2	0.534
MRPS16	0.528
LARS2	0.527
MTRF1L	0.526
WARS2	0.525
PET117	0.525
SCO2	0.525
GFM1	0.524
RPUSD4	0.524
MRPL47	0.523
NDUFA2	0.523
NDUFB9	0.522
MRPL12	0.521
RNASEH1	0.521
DAP3	0.52
ACAD9	0.52
NDUFAF7	0.514
GRSF1	0.513
GATC	0.512
MRPS6	0.512
C17orf89	0.509
MRPS12	0.508
POLG2	0.505
NDUFA1	0.503
COA3	0.5
FASTKD2	0.495
NDUFA11	0.494
MRPS10	0.494
C12orf65	0.491
COX11	0.488
RPUSD3	0.488
NDUFC2	0.488
MRPS26	0.488
NDUFS2	0.488
MTO1	0.486
ICT1	0.485
NDUFAF3	0.485
MCAT	0.485
BCS1L	0.484
NDUFB5	0.484
FARS2	0.483
NUBPL	0.483
HMGXB3	0.483
POLG	0.479
MRPS22	0.477
SSBP1	0.477
MRPS27	0.475
TMEM242	0.474
MRPL18	0.474
MTERFD2	0.473
MRPL55	0.471
MRPL41	0.468
COX16	0.464
COQ2	0.463
MTIF2	0.463
VARS2	0.461
MRPL4	0.46
TEFM	0.46
NDUFAF6	0.459
NDUFB6	0.458
MRPL3	0.458
SFXN4	0.457
COQ3	0.456
GLRX5	0.456
TUFM	0.455
KIAA0391	0.455
HARS2	0.454
MRPL20	0.453
C1QBP	0.453
MRPS18A	0.453
MTPAP	0.453
DDX28	0.452
MRPL44	0.451
NDUFB7	0.451
GTPBP6	0.451
MRPS2	0.45
MTIF3	0.449
MRPS25	0.449
MRP63	0.448
NDUFAF5	0.448
COQ7	0.447
MALSU1	0.447
TOMM20	0.446
MARS2	0.446
PITRM1	0.446
SUPV3L1	0.445
MRPL22	0.444
POLRMT	0.444
MRPS14	0.444
MRPS11	0.442
PNPT1	0.442
COA6	0.441
DNLZ	0.441
TRUB2	0.441
MTERFD1	0.439
ATP5SL	0.439
MRPS24	0.439
NDUFB2	0.438
PTCD1	0.438
MRPL49	0.437
MRPL48	0.437
HIGD2A	0.436
TSFM	0.436
TOMM6	0.435
ATP5D	0.435
RNMTL1	0.435
MRPL43	0.434
MRPS33	0.434
ERAL1	0.433
NDUFAF1	0.433
TIMMDC1	0.433
TIMM8B	0.431
COX15	0.43
CARS2	0.427
SLC25A3	0.426
ATP5C1	0.426
TMEM126B	0.426
NDUFS5	0.424
MRPL11	0.423
ATPAF2	0.421
LRPPRC	0.421
NDUFS7	0.421
NDUFA6	0.42
NDUFC1	0.42
MRPL38	0.418
MRPL13	0.418
DARS2	0.418
ECSIT	0.416
NSUN4	0.414
MRPL42	0.413
SARS2	0.413
SLC25A26	0.411
UQCC2	0.408
DHRSX	0.407
OPA1	0.406
NDUFAF4	0.406
CLPP	0.405
NDUFS8	0.404
MRPL2	0.404
PMVK	0.403
NDUFA8	0.402
MRPL15	0.401
ALAS1	0.4
FOXRED1	0.4
PDSS1	0.4

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1212
Expression level (log2 read counts): 5.56

Expression Distribution

regulation of respiratory system process
regulation of respiratory gaseous exchange
mitochondrial ribosome
regulation of mitochondrial translation
regulation of mitochondrial gene expression
GTPase activity
regulation of translation
mitochondrial matrix
GTP binding
mitochondrial inner membrane
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
regulation of system process
mitochondrion