PELO

Gene Information

Official Symbol: PELO
Official Name: pelota mRNA surveillance and ribosome rescue factor
Aliases and Previous Symbols: N/A
Entrez ID: 53918
UniProt: Q9BRX2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000250, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
OICR-9429 10μM R03 exp142	-1.89
Bleomycin 5μM R08 exp459	1.79
Aphidicolin 0.4μM R08 exp440	1.88
CFI-400945 25μM R08 exp469	1.89
Rotenone 20μM R00 exp34	1.97
Pimelic-diphenylamide-106 5μM R00 exp28	1.98
UM0129480 7μM R02 exp85	2.02
Cryptotanshinone 12μM R05 exp227	2.05
Monensin 0.3μM R08 exp507	2.05
Actinomycin-D 0.001μM R00 exp3	2.08
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.25
Vinblastine 0.2μM R03 exp108	2.33
HMS-I1 10μM R06 exp256	2.39
SB743921 0.001μM R05 exp244	2.54
BI-2536 0.02μM R03 exp96	2.71
42°C R08 exp539	2.72
Nocodazole 0.2μM R00 exp24	2.81
Rotenone 2μM R00 exp33	2.81
DABN 20μM R00 exp17	2.91
BI-6727 0.04μM R03 exp98	3
Etoposide 0.3μM R05 exp199	3.1
GSK461364A 0.1μM R03 exp126	3.34
Nocodazole 0.2μM R02 exp64	3.35
Etoposide 1μM R00 exp19	3.46
Vinblastine 0.015μM R05 exp208	3.48

Gene	Correlation
HARS	0.652
MED16	0.643
RPTOR	0.64
THG1L	0.634
ALG1	0.62
PMM2	0.607
GMPPB	0.604
RNMT	0.597
TRIAP1	0.582
DPAGT1	0.58
AARS	0.58
BUB3	0.579
TSEN54	0.571
CCDC101	0.569
EIF4E	0.565
MTOR	0.564
RTCB	0.561
GFPT1	0.557
PAM16	0.556
UTP23	0.555
UAP1	0.547
ALG2	0.545
TTI2	0.544
DOHH	0.544
DHPS	0.534
RBM14	0.532
ATXN10	0.531
MEAF6	0.53
EXOC3	0.53
GTF3C4	0.529
YARS	0.528
ORAOV1	0.526
FNTA	0.521
TMEM41B	0.52
DAD1	0.519
UHRF1	0.517
WDR24	0.517
WDR59	0.516
TSEN34	0.505
TGS1	0.504
VEZT	0.503
NAE1	0.501
DDX20	0.5
TRMT5	0.5
EPRS	0.5
MLLT1	0.499
SRP14	0.499
ADSL	0.499
HSPD1	0.498
GNB1L	0.498
PPP2R3C	0.496
ALG13	0.49
VHL	0.49
MED23	0.49
TLE4	0.488
DDOST	0.487
RPP21	0.484
GTF3C3	0.481
TTI1	0.481
ENY2	0.479
NARS	0.478
MAD2L1	0.478
GTF3C2	0.476
THOC6	0.475
HCCS	0.473
ALG14	0.473
DPF2	0.473
CBFB	0.472
SPCS2	0.471
MARS	0.467
PLAA	0.466
TEN1	0.464
DR1	0.463
TRNT1	0.463
TBCA	0.461
LSM11	0.458
SLC25A19	0.458
GEMIN5	0.457
POLR3H	0.457
TAMM41	0.456
MED4	0.454
SRP72	0.453
SEH1L	0.453
GTF3C6	0.451
PHB	0.45
SPCS3	0.45
PDAP1	0.45
RPE	0.45
ALG5	0.448
SDHA	0.448
GEMIN8	0.446
KNTC1	0.446
TXNRD1	0.445
NHLRC2	0.444
WDR82	0.443
VMP1	0.443
RPN1	0.442
EXOC4	0.442
HAUS8	0.44
TMED10	0.439
CCT7	0.438
GTF2A2	0.438
DDX39A	0.437
BAP1	0.435
OIP5	0.435
OSGEP	0.433
MAD1L1	0.432
ZNF259	0.431
FAF2	0.428
DICER1	0.427
ABCF1	0.424
CARS	0.424
DHDDS	0.423
ATP5J	0.423
SLC35B1	0.422
EIF3F	0.421
ATP5O	0.42
LSMD1	0.419
POLR3B	0.419
KCTD5	0.418
NSMCE1	0.418
LSM10	0.418
GTF3A	0.418
PPCS	0.417
PPP4C	0.417
TELO2	0.416
ROMO1	0.415
APAF1	0.414
MAX	0.414
GEMIN6	0.414
ACTR10	0.413
CRCP	0.413
LAMTOR5	0.412
CEP350	0.412
PYROXD1	0.411
EEF1E1	0.411
UBE2G2	0.41
PPP6C	0.409
CASP9	0.409
TAZ	0.409
ATP5H	0.407
CHCHD4	0.407
DOLK	0.406
DDX1	0.406
SEC62	0.406
CSNK2B	0.405
MAPK14	0.405
BUB1B	0.405
DCTN6	0.405
CTDNEP1	0.403
GABPA	0.402
PIK3R4	0.402
PGGT1B	0.401
LMO2	0.401
UBA3	0.401
PISD	0.401
NUP50	0.4
RAD1	0.4

Global Fraction of Cell Lines Where Essential: 436/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	17/28
blood	13/28
bone	19/26
breast	14/33
central nervous system	25/56
cervix	3/4
colorectal	8/17
esophagus	10/13
fibroblast	0/1
gastric	11/16
kidney	10/21
liver	10/20
lung	56/75
lymphocyte	11/16
ovary	12/26
pancreas	13/24
peripheral nervous system	8/16
plasma cell	5/15
prostate	0/1
skin	13/24
soft tissue	4/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	20/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 139
Expression level (log2 read counts): 3.5

Expression Distribution

eRF1 1
eRF1 2
eRF1 3

nonfunctional rRNA decay
nuclear-transcribed mRNA catabolic process, non-stop decay
nuclear-transcribed mRNA catabolic process, no-go decay
ribosome disassembly
inner cell mass cell proliferation
ribonucleoprotein complex disassembly
mesenchymal to epithelial transition
RNA surveillance
blastocyst growth
rRNA catabolic process
ncRNA catabolic process
positive regulation of BMP signaling pathway
endonuclease activity
ribosome binding
organelle disassembly
endoderm development
regulation of BMP signaling pathway
blastocyst development
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
stem cell population maintenance
maintenance of cell number
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
rRNA metabolic process
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
protein-containing complex disassembly
ribonucleoprotein complex subunit organization
RNA catabolic process
regulation of cellular response to growth factor stimulus
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
in utero embryonic development
developmental growth
growth
cellular component disassembly
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process