TRMT10A

Entrez Summary: This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
UniProt Summary: S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)- methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CVT-10216 0.1μM R06 exp278	-2.62
L-BMAA 500 to 750μM on day4 R04 exp185	-2.32
Metformin 100 to 150μM on day4 R04 exp170	-2.32
Nicotinate 1000μM R03 exp140	-2.13
proTAME 5μM R04 exp187	-2.09
Beta-Estradiol 0.55μM R07 exp425	-2.06
Alpha-Amanitin 0.5μM R00 exp5	-2.06
VHL-ligand-1 20μM R07 exp421	-1.98
HMS-I2 1μM R06 exp286	-1.94
Pomalidomide 20μM R07 exp391	-1.85
Asunaprenir 3μM R07 exp336	-1.84
Pifithrin-alpha 20μM R07 exp390	-1.77
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.77
UM0011500 10μM R05 exp246	-1.76
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.74
THZ531 0.11μM R07 exp409	-1.73
Deferoxamine 11μM R07 exp350	1.75
Nocodazole 0.2μM R02 exp64	1.75
Tanespimycin 14μM R08 exp527	1.76
42°C R08 exp539	1.8
DABN racemic mixture R03 exp93	1.81
Nocodazole 0.1μM R03 exp94	1.82
PU-H71 1μM R08 exp515	1.82
BI-2536 0.0042μM R03 exp95	1.85
Taxol 0.004μM R03 exp103	1.85
CI-1040 9.5μM R08 exp472	1.86
R-DABN 8μM R03 exp111	1.87
Cerivastatin 0.15μM R05 exp226	1.94
HMS-I2 10μM R06 exp288	1.95
6-Thio-2-deoxyguanosine 2μM R06 exp259	2
Ammonium tetrathiomolybdate 10μM R08 exp448	2
BI-2536 0.02μM R03 exp96	2.04
LLY-283 2.6μM R06 exp290	2.21
CoCl2 18μM R07 exp346	2.24
SNS-032 15μM R08 exp443	2.27
Aphidicolin 0.4μM R08 exp440	2.3
UM131593 0.2μM R03 exp106	2.42
TIC10 10μM R08 exp532	2.44
Hinokiflavone 12μM R08 exp487	2.58
Monensin 0.3μM R08 exp507	2.59
Vinblastine 0.2μM R03 exp108	2.6
BI-6727 0.04μM R03 exp98	3.09
MS023 7μM R03 exp135	3.12
Olaparib 4μM R08 exp512	3.62
GSK461364A 0.1μM R03 exp126	3.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA (guanine(9)-N(1))-methyltransferase activity
tRNA (guanine-N1-)-methyltransferase activity
mitochondrial tRNA processing
mitochondrial RNA processing
tRNA methylation
mitochondrial RNA metabolic process
tRNA binding
RNA methylation
tRNA modification
tRNA processing
mitochondrial gene expression
RNA modification
tRNA metabolic process
actin cytoskeleton
macromolecule methylation
methylation
ncRNA processing
ncRNA metabolic process
nucleolus
RNA processing
mitochondrion
RNA binding
RNA metabolic process
gene expression