METTL17

Gene Information

Official Symbol: METTL17
Official Name: methyltransferase like 17
Aliases and Previous Symbols: N/A
Entrez ID: 64745
UniProt: Q9H7H0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be a component of the mitochondrial small ribosomal subunit. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.4μM R03 exp99	-1.71
Calcium Ionophore 0.4μM R07 exp342	1.71
Thimerosal 0.85μM R08 exp529	1.71
Hydroxyurea 100μM R07 exp329	1.73
iCRT14 30μM R08 exp492	1.74
TIC10 10μM R08 exp532	1.76
BI-D1870 3.15μM R02 exp66	1.85
GSK-J4 1.5μM R08 exp441	1.86
Mubritinib 0.2μM R01 exp48	1.89
Arsenate 40μM R06 exp264	1.91
Nutlin-3A 1.6μM R06 exp294	1.93
UM0125461 0.74μM R02 exp84	1.97
CR131-b 0.005μM R08 exp474	1.98
Genistein 15μM R07 exp360	1.99
Azithromycin 100μM R08 exp452	2.08
BML-284 0.09μM R08 exp460	2.09
LLY-283 2.6μM R06 exp290	2.21
Oligomycin-A 2μM R00 exp25	2.44
Torin1 0.08μM R02 exp82	2.85

Gene	Correlation
PET117	0.633
PET112	0.623
NARS2	0.608
FTSJ2	0.6
PARS2	0.599
MRPS27	0.586
QRSL1	0.586
POLRMT	0.586
NDUFB11	0.576
HSD17B10	0.576
CHCHD1	0.575
FASTKD2	0.574
MRPS6	0.573
COX11	0.571
LARS2	0.57
NDUFA2	0.569
AARS2	0.568
COA3	0.567
SCO2	0.567
GFM2	0.567
MRPL47	0.566
MRPL21	0.565
MRPS21	0.562
SELRC1	0.562
DDX28	0.562
EARS2	0.561
ACAD9	0.559
YARS2	0.551
MRPL13	0.55
RBFA	0.55
MRPS5	0.547
GTPBP10	0.546
NDUFB9	0.546
MTIF2	0.544
NDUFAF7	0.542
TARS2	0.542
MRPS12	0.54
MTG1	0.539
MRPS26	0.539
MRPS34	0.534
MRPL45	0.534
RARS2	0.532
RPUSD3	0.529
NDUFA11	0.527
GFM1	0.526
GRSF1	0.524
C12orf65	0.523
MRPL17	0.523
MTO1	0.522
POLG	0.521
MRPL23	0.521
MTRF1L	0.52
NSUN4	0.52
NDUFS2	0.519
NDUFA3	0.518
COA6	0.517
TFB1M	0.517
DAP3	0.517
MRPL3	0.516
PTCD3	0.514
NUBPL	0.514
WARS2	0.513
RPUSD4	0.511
MRPS25	0.51
MTERFD2	0.509
MRPL53	0.508
VARS2	0.507
GTPBP6	0.506
MRPS35	0.506
HARS2	0.502
POLG2	0.502
MIPEP	0.496
MRPL15	0.496
NDUFA1	0.494
MRPS16	0.494
FASTKD5	0.494
MTG2	0.49
MRPL42	0.489
MRPL4	0.488
MRPS24	0.488
NDUFA8	0.487
MRPS23	0.483
MTERFD1	0.482
MARS2	0.482
MRPS10	0.481
CLPP	0.48
HMGXB3	0.479
NDUFS5	0.479
DARS2	0.479
MALSU1	0.478
WBSCR16	0.478
FARS2	0.477
BCS1L	0.475
COQ7	0.475
COX16	0.474
TEFM	0.473
MRP63	0.472
NDUFAF3	0.471
MRPL2	0.467
TIMMDC1	0.467
ERAL1	0.466
COX15	0.466
GATC	0.466
COQ2	0.466
NDUFC2	0.465
TRUB2	0.465
RNMTL1	0.463
MRPL51	0.463
MRPL12	0.462
PNPT1	0.462
CARS2	0.46
NDUFS7	0.459
MCAT	0.459
MRPL1	0.459
NDUFA10	0.457
NDUFB7	0.456
GTPBP8	0.456
MRPS14	0.456
NDUFB6	0.455
MRPL43	0.454
MRPL49	0.453
XPNPEP3	0.452
MRPS11	0.45
RNASEH1	0.45
MRPL18	0.449
SLC31A1	0.449
NDUFB4	0.448
MRPL44	0.448
MRPS7	0.447
IBA57	0.447
NDUFC1	0.446
SSBP1	0.445
PREPL	0.444
NOA1	0.444
NDUFAF6	0.444
ICT1	0.442
SCO1	0.442
MTRF1	0.44
SLC25A3	0.438
COX17	0.437
MRPS18A	0.437
KIAA0391	0.436
PITRM1	0.436
NDUFB10	0.435
NDUFAF5	0.433
ATP5SL	0.432
NDUFB2	0.431
FOXRED1	0.431
NDUFS8	0.43
MRPL37	0.429
ECSIT	0.427
MRPL52	0.426
MRPS33	0.426
AIFM1	0.425
TUFM	0.425
LRPPRC	0.423
NDUFV1	0.423
COX20	0.421
MRPL22	0.421
TRIT1	0.419
NDUFAF1	0.419
MTPAP	0.418
TOMM20	0.418
PDSS2	0.416
PDE12	0.415
MRPS18B	0.415
SLC25A51	0.411
COX19	0.41
YBEY	0.409
COX6B1	0.408
RTN4IP1	0.408
NDUFV2	0.408
C1QBP	0.407
MRPS28	0.404
MRPL20	0.404
NDUFA13	0.403
MRPL55	0.402
MCUR1	0.401
MRPS17	0.4
MRPL14	0.4

Global Fraction of Cell Lines Where Essential: 37/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	3/26
breast	2/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	1/20
lung	5/75
lymphocyte	2/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 826
Expression level (log2 read counts): 6.82

Expression Distribution