ROMO1
Gene Information
- Official Symbol: ROMO1
- Official Name: reactive oxygen species modulator 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 140823
- UniProt: P60602
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Pfam Domains GO Terms
Pfam Domains
| Romo1 |
GO Terms
| replicative cell aging |
| cytolysis in other organism |
| TIM23 mitochondrial import inner membrane translocase complex |
| protein insertion into mitochondrial inner membrane |
| establishment of protein localization to mitochondrial membrane |
| protein import into mitochondrial matrix |
| protein insertion into mitochondrial membrane |
| multi-organism cellular process |
| cytolysis |
| protein transmembrane import into intracellular organelle |
| protein insertion into membrane |
| inner mitochondrial membrane organization |
| intracellular protein transmembrane transport |
| killing of cells of other organism |
| disruption of cells of other organism |
| protein targeting to mitochondrion |
| protein transmembrane transport |
| cell aging |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| establishment of protein localization to mitochondrion |
| protein localization to mitochondrion |
| defense response to Gram-negative bacterium |
| cell killing |
| mitochondrial transmembrane transport |
| defense response to Gram-positive bacterium |
| positive regulation of reactive oxygen species metabolic process |
| antimicrobial humoral response |
| mitochondrial membrane organization |
| cellular response to reactive oxygen species |
| protein import |
| modification of morphology or physiology of other organism |
| regulation of reactive oxygen species metabolic process |
| response to reactive oxygen species |
| mitochondrial transport |
| cellular response to oxidative stress |
| establishment of protein localization to membrane |
| aging |
| defense response to bacterium |
| humoral immune response |
| protein targeting |
| response to oxidative stress |
| establishment of protein localization to organelle |
| mitochondrion organization |
| protein localization to membrane |
| response to bacterium |
| protein localization to organelle |
| molecular function |
| interspecies interaction between organisms |
| membrane organization |
| positive regulation of cell population proliferation |
| defense response to other organism |
| intracellular protein transport |
| cellular response to oxygen-containing compound |
| mitochondrion |
| transmembrane transport |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| cellular response to stress |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CRLS1 | 0.712 |
| TRIAP1 | 0.7 |
| PMM2 | 0.635 |
| TAZ | 0.633 |
| DOHH | 0.631 |
| DNLZ | 0.63 |
| OPA1 | 0.621 |
| THG1L | 0.601 |
| DPAGT1 | 0.594 |
| TAMM41 | 0.59 |
| UAP1 | 0.583 |
| RPE | 0.581 |
| SLC25A26 | 0.581 |
| ALG1 | 0.574 |
| TIMM13 | 0.566 |
| SRP14 | 0.564 |
| UBE2G2 | 0.563 |
| BAK1 | 0.563 |
| APAF1 | 0.561 |
| HCCS | 0.557 |
| KDSR | 0.557 |
| CASP9 | 0.55 |
| PLAA | 0.549 |
| VDAC2 | 0.547 |
| PGM3 | 0.53 |
| SERF2 | 0.529 |
| RPTOR | 0.528 |
| SEC62 | 0.527 |
| ATP5A1 | 0.526 |
| ATP5O | 0.523 |
| TRMT10A | 0.521 |
| SUPV3L1 | 0.52 |
| MBTPS2 | 0.517 |
| DHRSX | 0.51 |
| RPIA | 0.507 |
| PARL | 0.507 |
| FAF2 | 0.504 |
| TRMT61A | 0.504 |
| MLST8 | 0.503 |
| SRD5A3 | 0.503 |
| ATXN10 | 0.503 |
| ATP2A2 | 0.502 |
| PPCS | 0.496 |
| AASDHPPT | 0.493 |
| ALG5 | 0.491 |
| CYCS | 0.491 |
| ALG6 | 0.49 |
| PDPK1 | 0.486 |
| GFPT1 | 0.485 |
| KCTD5 | 0.485 |
| TRNT1 | 0.484 |
| UHRF1 | 0.48 |
| TKT | 0.478 |
| VEZT | 0.478 |
| NSD1 | 0.475 |
| CEPT1 | 0.474 |
| MARCH5 | 0.473 |
| PGS1 | 0.471 |
| BAP1 | 0.471 |
| MBTPS1 | 0.468 |
| WDR24 | 0.468 |
| HSPD1 | 0.467 |
| SEC63 | 0.466 |
| UBQLN1 | 0.466 |
| ORAOV1 | 0.466 |
| ATP5B | 0.465 |
| MRPS6 | 0.462 |
| GTF3C6 | 0.462 |
| MRPS34 | 0.46 |
| PDSS1 | 0.46 |
| CTDNEP1 | 0.459 |
| EXOC4 | 0.458 |
| METAP2 | 0.457 |
| KIAA0391 | 0.457 |
| PGLS | 0.456 |
| BPTF | 0.455 |
| ENY2 | 0.455 |
| ATP5D | 0.453 |
| ALG13 | 0.452 |
| DAD1 | 0.452 |
| GTF3C4 | 0.452 |
| PAM16 | 0.451 |
| RNMT | 0.449 |
| PTPMT1 | 0.449 |
| SSB | 0.447 |
| MRPL21 | 0.447 |
| DOLK | 0.446 |
| UTP23 | 0.446 |
| CBFB | 0.445 |
| PPA2 | 0.445 |
| RPUSD4 | 0.445 |
| RPN1 | 0.444 |
| TMEM41B | 0.444 |
| COQ3 | 0.443 |
| YARS2 | 0.443 |
| MFN1 | 0.442 |
| MRPS18A | 0.441 |
| FH | 0.441 |
| UBE2M | 0.441 |
| PISD | 0.44 |
| ATIC | 0.44 |
| MRPS14 | 0.439 |
| DHPS | 0.439 |
| PARS2 | 0.438 |
| SEC61G | 0.438 |
| ALG2 | 0.437 |
| ZZZ3 | 0.437 |
| LONP1 | 0.436 |
| ELP3 | 0.436 |
| MRPL23 | 0.433 |
| MAPKAP1 | 0.432 |
| LSM10 | 0.432 |
| LAMTOR4 | 0.431 |
| DAP3 | 0.429 |
| TTC4 | 0.429 |
| PPP2R3C | 0.429 |
| BCS1L | 0.428 |
| UBE2J1 | 0.428 |
| ATP5J | 0.427 |
| DARS2 | 0.427 |
| PTDSS1 | 0.426 |
| ATAD1 | 0.425 |
| RTCB | 0.423 |
| PDAP1 | 0.421 |
| TPI1 | 0.421 |
| ENO1 | 0.42 |
| TRIM28 | 0.418 |
| CD81 | 0.417 |
| MRPS16 | 0.415 |
| DDOST | 0.415 |
| PELO | 0.415 |
| NAE1 | 0.414 |
| GTF3C3 | 0.414 |
| SEC61B | 0.412 |
| RABIF | 0.412 |
| DR1 | 0.412 |
| OST4 | 0.411 |
| GMPPB | 0.411 |
| BRWD1 | 0.409 |
| CHCHD4 | 0.408 |
| ALG8 | 0.408 |
| ATP5H | 0.408 |
| IRF2BP2 | 0.407 |
| SLC25A20 | 0.407 |
| PNPT1 | 0.407 |
| TRMT5 | 0.407 |
| FECH | 0.406 |
| COQ6 | 0.405 |
| MRPL47 | 0.404 |
| MTOR | 0.404 |
| THOC6 | 0.404 |
| ADSL | 0.403 |
| RBFA | 0.403 |
| DIABLO | 0.403 |
| TIMM8B | 0.402 |
| TXNL4B | 0.402 |
| GPI | 0.402 |
| SLMO2 | 0.401 |
| TIMM44 | 0.401 |
| GEMIN6 | 0.4 |
| CEP57 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 559/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 22/28 |
| blood | 24/28 |
| bone | 18/26 |
| breast | 28/33 |
| central nervous system | 39/56 |
| cervix | 2/4 |
| colorectal | 12/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 11/16 |
| kidney | 14/21 |
| liver | 16/20 |
| lung | 55/75 |
| lymphocyte | 13/16 |
| ovary | 19/26 |
| pancreas | 18/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 11/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 5/9 |
| thyroid | 1/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 23/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 61
- Expression level (log2 read counts): 4.23
Expression Distribution
ROMO1 Expression in NALM6 Cells: 4.23
