ZRSR2
Gene Information
- Official Symbol: ZRSR2
- Official Name: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8233
- UniProt: Q15696
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008].
- UniProt Summary: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2587
- Expression level (log2 read counts): 3.87
ZRSR2 Expression in NALM6 Cells: 3.87
