PET112

Gene Information

Official Symbol: GATB
Official Name: glutamyl-tRNA amidotransferase subunit B
Aliases and Previous Symbols: N/A
Entrez ID: 5188
UniProt: O75879
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19805282}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubacin 1.6μM R07 exp416	1.74
UM131593 0.2μM R03 exp106	1.74
Aphidicolin 0.4μM R08 exp440	1.79
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.8
Radicicol 0.16μM R05 exp242	1.81
Amiloride 100μM R08 exp447	1.9
Thimerosal 0.85μM R08 exp529	1.9
CoCl2 18μM R07 exp346	1.93
UM0125461 0.74μM R02 exp84	1.95
Calcium Ionophore 0.4μM R07 exp342	2.18
Genistein 15μM R07 exp360	2.27
Oligomycin-A 2μM R00 exp25	2.89

Gene	Correlation
QRSL1	0.719
NARS2	0.71
EARS2	0.659
PET117	0.649
YARS2	0.643
FTSJ2	0.641
COA3	0.639
SELRC1	0.638
LARS2	0.63
MRPS21	0.627
DAP3	0.624
METTL17	0.623
MRPS16	0.619
DDX28	0.619
GTPBP10	0.616
HSD17B10	0.614
SCO2	0.612
AARS2	0.61
PARS2	0.609
TARS2	0.606
RARS2	0.602
MRPL21	0.601
WARS2	0.6
FASTKD5	0.599
MTG1	0.596
MRPL23	0.593
VARS2	0.592
MRPL45	0.592
MRPS12	0.59
RPUSD3	0.587
MRPS6	0.587
MRPL47	0.586
NSUN4	0.583
GFM2	0.583
MRPS34	0.582
RPUSD4	0.581
NDUFB11	0.579
ACAD9	0.575
RBFA	0.575
MRPS10	0.575
MRPS27	0.572
MRPL53	0.571
ERAL1	0.57
COA6	0.569
HARS2	0.569
COX11	0.569
MTG2	0.567
MRPS25	0.567
MRPS35	0.566
MRPL4	0.565
POLG2	0.562
MALSU1	0.562
TFB1M	0.562
MARS2	0.561
MTIF2	0.56
CARS2	0.56
MTERFD1	0.559
MRPS26	0.556
TEFM	0.549
NDUFA2	0.549
GFM1	0.548
COX20	0.547
NDUFA3	0.546
FASTKD2	0.545
NUBPL	0.543
DARS2	0.542
MRPS5	0.542
MRPS14	0.542
COX15	0.541
WBSCR16	0.541
MTRF1L	0.54
GTPBP6	0.54
GTPBP8	0.533
MRPS18A	0.533
XPNPEP3	0.529
RNMTL1	0.529
NDUFA11	0.527
MRPL3	0.525
MRPL43	0.523
MRPL12	0.522
MTO1	0.522
NDUFS2	0.521
NDUFA1	0.52
MRP63	0.516
TRUB2	0.515
GRSF1	0.515
MRPL49	0.511
MRPL20	0.506
GATC	0.506
ATP5SL	0.506
C10orf2	0.506
MCAT	0.504
ICT1	0.504
MRPS22	0.504
COX16	0.503
POLG	0.503
C12orf65	0.502
TIMMDC1	0.499
CLPP	0.496
NDUFAF7	0.496
FARS2	0.495
NDUFV1	0.494
MRPL17	0.494
MRPL13	0.494
IBA57	0.493
MRPL1	0.493
TOMM20	0.491
NDUFAF1	0.491
NDUFB9	0.487
MRPL18	0.483
NDUFC2	0.481
CHCHD1	0.481
NDUFAF6	0.479
MIPEP	0.478
MTERFD2	0.478
MRPL42	0.477
C1QBP	0.476
NDUFAF3	0.476
NDUFAF5	0.473
RNASEH1	0.473
MRPS24	0.471
PNPT1	0.471
POLRMT	0.469
SSBP1	0.469
MRPL33	0.468
MRPL15	0.466
MRPS7	0.465
MRPL2	0.464
KIAA0391	0.464
PITRM1	0.459
COQ7	0.458
TSFM	0.458
LRPPRC	0.458
PTCD3	0.457
SARS2	0.454
COQ2	0.454
NDUFA8	0.452
MRPL44	0.452
BCS1L	0.451
METTL1	0.451
MRPS2	0.451
HMGXB3	0.45
ECSIT	0.45
RTN4IP1	0.45
MRPL22	0.449
MRPL55	0.448
MRPS23	0.446
COX19	0.446
MRPS33	0.445
MRPL39	0.444
NDUFB6	0.443
TMEM242	0.443
TFB2M	0.442
NDUFS5	0.442
NDUFA6	0.44
NDUFS1	0.439
NDUFS8	0.436
AIFM1	0.435
MRPL11	0.434
TFAM	0.434
MRPS9	0.432
TMEM261	0.432
HIGD2A	0.431
MRPL37	0.43
PTCD1	0.429
NDUFB10	0.429
ATP5C1	0.428
GLRX5	0.427
NDUFC1	0.426
SFXN4	0.425
PDE12	0.425
FOXRED1	0.423
PREPL	0.423
NDUFB2	0.422
MINOS1	0.422
TIMM17A	0.421
MRPL35	0.421
SCO1	0.419
NDUFB7	0.418
MRPL28	0.418
FASTKD1	0.416
MRPS28	0.414
TUFM	0.414
COQ4	0.412
MRPL51	0.412
NDUFB5	0.412
MRPL48	0.412
OPA1	0.412
NDUFA10	0.411
SLC25A3	0.411
NDUFB4	0.41
ALDH18A1	0.41
DNLZ	0.408
MPV17L2	0.408
MTPAP	0.407
NDUFAF4	0.407
MRPS18B	0.405
SUPV3L1	0.405
COX7B	0.404
MTIF3	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 765
Expression level (log2 read counts): 4.45

Expression Distribution

GatB Yqey
GatB N

glutamyl-tRNA(Gln) amidotransferase complex
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
glutaminyl-tRNAGln biosynthesis via transamidation
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression