MRPL15

Gene Information

Official Symbol: MRPL15
Official Name: mitochondrial ribosomal protein L15
Aliases and Previous Symbols: N/A
Entrez ID: 29088
UniProt: Q9P015
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pomalidomide 20μM R07 exp391	-2.18
Deguelin 0.05μM R02 exp69	-2.08
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.93
Doxorubicin 0.02μM R08 exp478	1.72
Taxol 0.004μM R03 exp103	1.74
Atovaquone 15μM R08 exp451	1.76
MK2206 4μM R08 exp504	1.76
Hydroxyurea 100μM R07 exp329	1.77
Mitomycin-C 0.06μM R08 exp503	1.79
PU-H71 1μM R08 exp515	1.79
TIC10 10μM R08 exp532	1.93
Salinomycin 3.5μM R08 exp521	1.99
WYE-354 6μM R02 exp90	2.01
GSK-J4 1.5μM R08 exp441	2.23

Gene	Correlation
MRPS14	0.644
HSD17B10	0.639
DAP3	0.622
SARS2	0.61
MRPS5	0.606
TUFM	0.605
MRPL21	0.597
NDUFA3	0.597
YARS2	0.596
GFM2	0.591
MRPL23	0.59
MRPS34	0.588
MRP63	0.587
MRPL47	0.582
MRPS6	0.58
MRPS21	0.578
TARS2	0.568
MRPS18A	0.568
GFM1	0.567
SCO2	0.566
MRPS16	0.561
MRPL53	0.561
NDUFB11	0.559
MRPS33	0.559
SUPV3L1	0.553
TEFM	0.552
RBFA	0.551
DARS2	0.551
RPUSD4	0.551
QRSL1	0.55
MRPS11	0.548
MRPS26	0.547
MARS2	0.546
COX16	0.543
SELRC1	0.542
PARS2	0.542
NDUFAF7	0.541
MRPS25	0.539
VARS2	0.539
NDUFS7	0.537
MRPS9	0.534
WBSCR16	0.531
CHCHD4	0.529
NDUFA2	0.528
COX17	0.528
C10orf2	0.527
RPUSD3	0.527
BCS1L	0.526
RNASEH1	0.524
HARS2	0.523
MRPL3	0.522
ATP5SL	0.519
MTG2	0.519
PNPT1	0.518
FARS2	0.518
GTPBP10	0.517
COX7B	0.516
NDUFB3	0.516
FASTKD5	0.513
COA3	0.51
COX6C	0.508
MRPL34	0.506
PDSS1	0.506
MRPS24	0.505
NARS2	0.505
C17orf89	0.504
C12orf65	0.504
SLC25A26	0.502
GATC	0.502
MRPS23	0.501
MRPS12	0.501
EARS2	0.5
MRPS2	0.498
RARS2	0.496
METTL17	0.496
MRPL20	0.493
NDUFB5	0.493
NDUFAF4	0.493
TRIAP1	0.493
NDUFC2	0.493
MTPAP	0.492
POLG	0.491
NDUFB9	0.49
COQ2	0.489
KIAA0391	0.488
ELAC2	0.486
NDUFB6	0.483
MTRF1L	0.483
NDUFAF3	0.48
COA6	0.479
NDUFS2	0.479
TOMM20	0.477
DHX30	0.476
CHCHD1	0.476
NDUFA11	0.475
MRPS22	0.475
MRPL32	0.473
MRPL55	0.472
VEZT	0.472
MRPL45	0.469
MRPL42	0.467
TMEM126B	0.467
MRPL11	0.467
MRPL12	0.466
PET112	0.466
RNMTL1	0.465
AASDHPPT	0.463
UQCR10	0.462
TIMM8B	0.461
IBA57	0.46
FOXRED1	0.459
MTERFD2	0.457
COQ5	0.456
COQ7	0.454
MRPL36	0.453
MRPL43	0.45
MRPL27	0.45
NDUFA1	0.45
RTN4IP1	0.45
PGM3	0.449
POLRMT	0.448
TMEM261	0.446
AARS2	0.446
LARS2	0.446
MRPL44	0.446
MRPL33	0.445
RPIA	0.444
PTCD3	0.443
FTSJ2	0.443
MRPL4	0.441
COX15	0.44
PPA2	0.439
ATP5D	0.438
POLG2	0.436
ATP5C1	0.435
COA5	0.434
TFAM	0.434
MRPL22	0.432
COX5A	0.431
ATP5A1	0.43
MRPS7	0.43
HCCS	0.429
MTERFD1	0.428
TPK1	0.428
ALG8	0.428
ALG5	0.427
NDUFA10	0.426
TMEM242	0.426
UQCRC2	0.426
MRPL37	0.424
TRMT10C	0.424
ECSIT	0.424
ANGEL2	0.423
MRPL41	0.423
DHRSX	0.423
AIFM1	0.422
CARS2	0.419
GRSF1	0.418
ATP5J	0.417
ATP5F1	0.417
CRLS1	0.417
MTIF3	0.417
ACAD9	0.416
TRUB2	0.415
FASTKD1	0.415
ALG6	0.415
NDUFA8	0.414
UQCRQ	0.414
MRPL13	0.414
NDUFB2	0.413
PPCS	0.412
GFER	0.412
TOMM22	0.411
NDUFC1	0.41
PITRM1	0.409
MIPEP	0.408
UQCC2	0.406
NDUFV1	0.405
MTO1	0.404
ATXN10	0.404
SRD5A3	0.402
NFU1	0.402
MTG1	0.401
MRPL2	0.401
FASTKD2	0.401
ISCA2	0.4
MALSU1	0.4

Global Fraction of Cell Lines Where Essential: 137/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	4/28
blood	6/28
bone	2/26
breast	7/33
central nervous system	7/56
cervix	1/4
colorectal	7/17
esophagus	5/13
fibroblast	0/1
gastric	3/16
kidney	4/21
liver	10/20
lung	16/75
lymphocyte	4/16
ovary	0/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1084
Expression level (log2 read counts): 5.83

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
cellular response to cytokine stimulus
response to cytokine
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression