NDUFB6

Gene Information

Official Symbol: NDUFB6
Official Name: N/ADH:ubiquinone oxidoreductase subunit B6
Aliases and Previous Symbols: N/A
Entrez ID: 4712
UniProt: O95139
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IWR1 50μM R08 exp495	-1.89
39°C R06 exp303	-1.88
Mubritinib 0.2μM R02 exp65	1.7
TIC10 10μM R08 exp532	1.7
Azithromycin 100μM R08 exp452	1.74
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.76
Chloroquine 32μM R08 exp470	1.76
PU-H71 1μM R08 exp515	1.76
ONC212 0.15μM R08 exp513	1.78
Dimethyloxaloylglycine 100μM R05 exp229	1.85
HMS-I2 10μM R06 exp288	2.02
Senexin-A 25μM R07 exp400	2.36
Hydroxyurea 100μM R07 exp329	2.41
Artemisinin 50μM R08 exp450	2.97
Oligomycin-A 2μM R00 exp25	3.03
Genistein 15μM R07 exp360	3.13
Atovaquone 15μM R08 exp451	3.42

Gene	Correlation
NDUFB11	0.689
ECSIT	0.632
NDUFA3	0.62
NDUFAF3	0.606
NDUFA11	0.604
NDUFA1	0.603
NDUFB5	0.601
NDUFS2	0.597
GRSF1	0.592
NDUFB9	0.588
NDUFA10	0.585
NDUFA2	0.585
NDUFAF7	0.576
RPUSD3	0.57
ACAD9	0.564
GTPBP10	0.56
MTO1	0.558
FTSJ2	0.556
MRPL21	0.546
GFM2	0.542
NDUFAF4	0.541
NDUFC2	0.541
HSD17B10	0.539
C17orf89	0.537
NDUFC1	0.536
NDUFS7	0.535
MTRF1L	0.534
NDUFA8	0.533
NARS2	0.528
RNASEH1	0.528
GFM1	0.528
NUBPL	0.526
NDUFAF1	0.524
MRPS16	0.523
FARS2	0.518
TARS2	0.518
NDUFS5	0.518
LARS2	0.518
ATP5SL	0.513
MIPEP	0.513
YARS2	0.512
WBSCR16	0.512
MRPL45	0.512
NDUFS1	0.51
NDUFS8	0.509
TMEM261	0.505
MRPS25	0.503
QRSL1	0.503
NDUFB2	0.501
MRPS5	0.5
MRPL47	0.499
MRPL23	0.499
NDUFV2	0.497
DAP3	0.497
NDUFB10	0.496
NDUFA6	0.496
NDUFB7	0.495
TIMMDC1	0.494
PARS2	0.494
NDUFAF5	0.493
DARS2	0.493
MRPS21	0.492
RBFA	0.491
POLG	0.491
SELRC1	0.489
GATC	0.487
CHCHD1	0.486
MRPS6	0.485
MRPL15	0.483
SSBP1	0.482
IBA57	0.481
NDUFAF6	0.481
MRPS26	0.48
RTN4IP1	0.48
NFU1	0.478
MRPS33	0.478
NDUFB4	0.478
C12orf65	0.478
HMGXB3	0.477
MRP63	0.477
MRPS34	0.476
FOXRED1	0.475
MRPL13	0.474
COX11	0.473
C10orf2	0.47
MALSU1	0.47
FASTKD2	0.47
AIFM1	0.468
AARS2	0.467
MRPS14	0.465
NDUFS3	0.462
NDUFV1	0.462
SUPV3L1	0.461
NDUFB3	0.459
MTG1	0.458
MRPS11	0.455
METTL17	0.455
PET117	0.454
GTPBP8	0.453
MRPS12	0.452
POLG2	0.452
TFB1M	0.451
NDUFA5	0.451
SCO2	0.45
VARS2	0.449
TUFM	0.449
EARS2	0.447
POLRMT	0.446
CARS2	0.445
ERAL1	0.445
MRPS18A	0.443
MRPL53	0.443
PET112	0.443
COX16	0.443
NSUN4	0.442
MCAT	0.441
MTG2	0.441
RPUSD4	0.441
TOMM20	0.44
MRPL4	0.439
MRPL3	0.438
TRUB2	0.437
MRPL12	0.436
SLC25A26	0.433
MRPS17	0.432
RNMTL1	0.432
MARS2	0.43
MRPS2	0.429
ELAC2	0.429
AASDHPPT	0.427
BCS1L	0.427
GLRX5	0.426
TEFM	0.425
COQ2	0.425
COA3	0.423
PDSS1	0.422
TMEM242	0.422
TPK1	0.422
TIMM21	0.42
MRPL44	0.419
SLC25A3	0.418
DDX28	0.418
MRPL46	0.417
CLPP	0.415
PTCD3	0.414
NOA1	0.414
MTERFD1	0.412
MRPS27	0.411
MRPS22	0.411
COA6	0.407
COX6B1	0.407
MRPL17	0.406
ICT1	0.405
MRPL2	0.405
FASTKD5	0.403
KIAA0391	0.402
RARS2	0.402
MRPS28	0.401
FH	0.401
RPIA	0.4

Global Fraction of Cell Lines Where Essential: 105/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	5/28
bone	3/26
breast	7/33
central nervous system	2/56
cervix	1/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	5/16
kidney	3/21
liver	7/20
lung	13/75
lymphocyte	2/16
ovary	3/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	6/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2137
Expression level (log2 read counts): 5.18

Expression Distribution

NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
mitochondrial membrane
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
mitochondrion
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization