TBC1D3K

Gene Information

Official Symbol: TBC1D3K
Official Name: TBC1 domain family member 3K
Aliases and Previous Symbols: N/A
Entrez ID: 101060351
UniProt: A0A087X1G2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.45
SNS-032 15μM R08 exp443	-2.33
Phenformin 20μM R05 exp212	-2.24
TIC10 10μM R08 exp532	-1.79
Doxorubicin 0.02μM R08 exp478	-1.77
ONC212 0.15μM R08 exp513	-1.76
RK-33 8μM R08 exp518	-1.73
CCCP 0.1μM R00 exp10	1.71
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.73
Cyclosporin-A 0.8μM R07 exp347	1.74
GSK-J5 1.5μM R08 exp484	1.78
Epigallocatechin gallate 20μM R05 exp230	1.81
Apcin 50 to 100μM on day4 R04 exp176	1.84
Rifampicin 1μM R00 exp31	1.89
IU1-47 25μM R04 exp182	1.96
Hypoxia 5%O2 R04 exp191	1.97
Golgicide-A 2μM R03 exp121	1.98
Metformin 40μM R03 exp132	2.06
Cidofovir 10μM R07 exp345	2.1
GSK-LSD1 10μM R03 exp123	2.13
GSK343 3μM R03 exp124	2.13
RO-3306 3 to 4μM on day4 R04 exp165	2.16
WNT3A 44ng/ml R08 exp537	2.33
3-Bromopyruvate 7μM R04 exp175	2.62
Cisplatin 0.35μM R06 exp273	2.7
proTAME 5μM R04 exp187	2.84

Gene	Correlation
POLR2J3	0.583
TCEB3CL2	0.579
RPS2	0.56
PSMA6	0.558
TFIP11	0.557
TCEB3CL	0.553
VASN	0.553
TCEB3C	0.546
C1QTNF9B	0.54
DTL	0.534
TIMELESS	0.525
PSMD3	0.523
C14orf93	0.523
RBBP5	0.516
CHD4	0.514
RPS28	0.511
FAM160A1	0.509
LRR1	0.509
DDTL	0.506
MYB	0.504
KCTD17	0.502
CDC73	0.502
CCDC94	0.501
PWP2	0.501
AQR	0.501
MT1E	0.5
RPL35	0.5
CBWD5	0.494
TICRR	0.493
CBWD3	0.493
PSMB1	0.493
PSMC1	0.492
SYT9	0.489
WDR87	0.489
SUPT6H	0.487
RRN3	0.487
CACTIN	0.487
SUPT5H	0.486
TPX2	0.485
HIST2H3C	0.482
HIST2H3A	0.482
EXOSC8	0.481
MDM2	0.48
RBM39	0.48
CGB2	0.48
ANKLE2	0.48
OGFR	0.48
SF3A1	0.479
RPS5	0.479
ZNF655	0.479
TRAIP	0.478
HIST2H2BF	0.478
RPL6	0.478
TYMS	0.477
PSMB4	0.477
RPS12	0.475
RPL34	0.475
MCOLN1	0.472
DDX56	0.472
EXOSC9	0.471
FCN2	0.47
NARFL	0.469
DNM2	0.469
NFATC4	0.467
RAD51	0.467
MYO1H	0.466
UTP3	0.466
BYSL	0.466
NOP16	0.465
PRPF8	0.465
RIOK2	0.465
PAN3	0.464
NUPL1	0.463
PSMB2	0.463
ORC1	0.463
SEC13	0.463
CKAP5	0.463
POLA1	0.463
MED17	0.463
KIF3C	0.462
PSAP	0.462
NOL10	0.461
RRP7A	0.461
RPS7	0.459
EXOSC5	0.459
CDC6	0.458
COPE	0.458
NOL12	0.458
CBWD6	0.458
ZNF574	0.458
UPF1	0.457
COL2A1	0.457
COPB1	0.456
PSMA7	0.456
AKIRIN2	0.455
ZFAND5	0.455
NPIPB5	0.455
RFXANK	0.455
SSH2	0.454
PDE4DIP	0.454
PSMD1	0.454
EXOSC3	0.453
PSMD11	0.452
POLA2	0.452
PBXIP1	0.451
CHAF1A	0.451
PSMD7	0.451
PCF11	0.45
TSPY1	0.45
KRT78	0.45
MADCAM1	0.45
CCNA2	0.449
RPS14	0.449
SLC4A1	0.449
TRIM52	0.449
CACNA1A	0.448
ZNF106	0.446
RPL30	0.446
GOLGA6B	0.445
NPIPB8	0.445
SULT1A3	0.444
SULT1A4	0.443
HAP1	0.443
IGFN1	0.443
SLC6A17	0.442
PPFIA4	0.442
RPS11	0.442
MED29	0.442
EBNA1BP2	0.441
KPNB1	0.441
MYO18A	0.44
BCL2L1	0.44
GOLGA6L4	0.439
SFPQ	0.439
HIST1H2BE	0.438
ORC6	0.438
RRP15	0.438
MYT1L	0.438
TOP1MT	0.437
MED14	0.437
PAN2	0.437
PSMC6	0.437
RPS19BP1	0.437
RPS20	0.436
PAF1	0.436
NBPF10	0.436
AAMP	0.436
NAPA	0.435
PSMD14	0.435
ARCN1	0.435
DNTTIP2	0.434
ACSF2	0.434
RNF4	0.433
RPA2	0.432
COPG1	0.432
S1PR4	0.431
CTR9	0.43
HIVEP3	0.43
GOLGA6L3	0.43
RPL9	0.429
CHMP2A	0.429
TERF2	0.428
POLE	0.428
CCDC64B	0.427
ADD2	0.426
SEL1L	0.426
MSH5	0.425
NUP107	0.425
CMYA5	0.424
XYLT2	0.424
INTS6	0.424
POLR1A	0.423
CASC3	0.423
PSMC2	0.423
FBXW9	0.422
FAM20A	0.422
NDC80	0.422
NUP62	0.422
ISCU	0.422
CEP192	0.421
COPZ1	0.421
FAM86B2	0.421
SRRT	0.42
WDR75	0.419
PSMB3	0.419
SNRPA1	0.418
CDCA3	0.418
GOLGA8O	0.418
TUBA8	0.417
LAD1	0.417
TSPY2	0.417
COPA	0.417
SCAF1	0.417
ANKLE1	0.417
PSMD2	0.417
WDR90	0.416
POLR2A	0.416
SART1	0.415
RPS9	0.415
TWISTNB	0.415
ZNF219	0.415
CDC45	0.415
ATP13A1	0.414
PSMD8	0.413
ELMOD3	0.413
FBXL19	0.412
RPS19	0.412
NUP153	0.412
C3orf17	0.412
PLA2G4F	0.411
NUP43	0.411
TSPY8	0.411
C2orf27B	0.411
AATF	0.411
RAD21	0.411
CNPY3	0.41
PSMD13	0.409
GID4	0.409
AKT1S1	0.409
NUP54	0.408
ATP6V1C1	0.408
RPL14	0.408
SMG1	0.408
GAR1	0.407
PALB2	0.407
PPM1D	0.407
COX7A2L	0.407
UBE2Q2L	0.406
FAM25B	0.406
RPS10	0.406
PRPF19	0.405
IK	0.405
MYH7B	0.405
PSMC5	0.405
SMG7	0.404
EGR2	0.404
XAB2	0.404
ADRA1D	0.404
MYH2	0.403
NUP85	0.403
ART5	0.403
EXD1	0.403
VPS28	0.402
MMS22L	0.402
CCDC116	0.402
CPLX3	0.401
RPS3A	0.401
NUP205	0.4
UBALD1	0.4
OR10G3	0.4
CASC5	0.4

Essentiality in NALM6

Essentiality Rank: 545
Expression level (log2 read counts): 0.47

Expression Distribution

activation of GTPase activity
Rab GTPase binding
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of hydrolase activity
intracellular protein transport
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport