FTSJ2

Gene Information

Official Symbol: MRM2
Official Name: mitochondrial rRNA methyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 29960
UniProt: Q9UI43
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GW501516 25μM R06 exp285	-1.73
HMS-I1 10μM R06 exp256	1.71
Chloroquine 32μM R08 exp470	1.76
Tubacin 1.6μM R07 exp416	1.76
Nocodazole 0.1μM R03 exp94	1.8
QNZ 0.01μM R05 exp241	1.8
Torin1 0.08μM R02 exp82	1.82
Phenformin 20μM R05 exp212	1.9
Genistein 15μM R07 exp360	1.92
Mubritinib 0.2μM R02 exp65	1.93
Nocodazole 0.2μM R00 exp24	1.97
BI-6727 0.04μM R03 exp98	1.99
NMS-873 0.07μM R07 exp380	2.02
BI-D1870 3.15μM R02 exp66	2.05
R-DABN 8μM R03 exp111	2.1
Rotenone 0.07μM R08 exp431	2.19
DABN racemic mixture R03 exp93	2.24
UM0125461 0.74μM R02 exp84	2.33
Nocodazole 0.2μM R02 exp64	2.39
Vinblastine 0.015μM R05 exp208	2.53
Thimerosal 0.85μM R08 exp529	2.56
Oligomycin-A 2μM R00 exp25	2.59
Hydroxyurea 100μM R07 exp329	2.83

Gene	Correlation
NARS2	0.688
QRSL1	0.682
LARS2	0.673
MRPS21	0.663
NDUFB11	0.65
YARS2	0.643
PET112	0.641
MRPL21	0.639
HSD17B10	0.622
RPUSD4	0.621
VARS2	0.621
AARS2	0.612
MRPL45	0.609
MRPL23	0.609
COA3	0.605
PARS2	0.604
GFM1	0.603
NDUFS2	0.601
METTL17	0.6
NDUFA3	0.599
EARS2	0.599
SELRC1	0.598
MRPS16	0.597
RPUSD3	0.593
WBSCR16	0.593
TEFM	0.592
DAP3	0.59
TARS2	0.59
MRPS25	0.59
MRPS5	0.586
MRPS6	0.585
MALSU1	0.584
DARS2	0.582
NDUFA1	0.58
DDX28	0.579
MTRF1L	0.578
MRPS34	0.577
GTPBP10	0.577
MRPS26	0.576
MRPS14	0.575
MRPL12	0.575
MARS2	0.571
TFB1M	0.569
NDUFAF7	0.566
GFM2	0.565
ERAL1	0.563
MRP63	0.562
MRPL47	0.561
PET117	0.558
MRPL3	0.557
MRPS12	0.557
NDUFB6	0.556
C12orf65	0.554
POLG2	0.552
CARS2	0.552
MRPL53	0.551
MTG1	0.551
SSBP1	0.548
MTERFD2	0.547
MRPS10	0.547
GATC	0.547
MRPL20	0.546
MRPS35	0.544
COX11	0.544
FASTKD5	0.542
MRPL4	0.541
RNMTL1	0.54
POLG	0.539
MTERFD1	0.538
NDUFC2	0.538
HMGXB3	0.537
NDUFAF3	0.537
RNASEH1	0.535
RARS2	0.534
FASTKD2	0.533
MTIF2	0.532
ACAD9	0.532
SCO2	0.532
PNPT1	0.53
RBFA	0.53
MRPL49	0.529
CHCHD1	0.529
NDUFA2	0.528
GRSF1	0.528
MRPL22	0.527
TIMMDC1	0.527
MRPS24	0.525
AIFM1	0.523
WARS2	0.522
MTO1	0.522
MRPL44	0.521
NDUFAF5	0.52
MRPS27	0.52
FARS2	0.52
POLRMT	0.517
BCS1L	0.516
ICT1	0.514
GTPBP8	0.513
TRUB2	0.512
NDUFV1	0.511
MTG2	0.509
COQ2	0.509
NUBPL	0.509
NDUFS7	0.508
PTCD3	0.507
MRPL17	0.507
ATP5SL	0.506
NDUFA11	0.504
NDUFS5	0.5
C10orf2	0.499
NDUFAF6	0.497
MRPL39	0.496
MTPAP	0.495
ECSIT	0.493
PREPL	0.492
TOMM20	0.492
HARS2	0.49
MRPS22	0.487
COX16	0.487
KIAA0391	0.486
COA6	0.486
MRPS18A	0.485
MIPEP	0.483
MRPL42	0.482
NSUN4	0.481
NDUFB9	0.481
CLPP	0.479
LRPPRC	0.479
MRPS7	0.479
SARS2	0.478
MRPS9	0.476
NDUFA8	0.475
XPNPEP3	0.475
MRPS17	0.473
RTN4IP1	0.472
MRPS33	0.472
TFAM	0.47
MRPL43	0.469
MINOS1	0.469
MRPL55	0.468
MRPL13	0.468
NDUFB7	0.467
MRPL52	0.466
MCAT	0.465
NDUFB5	0.462
SUPV3L1	0.462
NDUFAF1	0.46
TUFM	0.46
COX17	0.459
MRPL18	0.458
COX7B	0.457
HIGD2A	0.457
MRPS23	0.457
C17orf89	0.455
TIMM8B	0.454
COX15	0.453
ATP5C1	0.449
PTCD1	0.447
TMEM261	0.444
TOMM7	0.443
MRPL15	0.443
NDUFAF4	0.442
C1QBP	0.442
FOXRED1	0.442
COQ4	0.439
MRPL1	0.439
MRPS2	0.438
MRPL48	0.436
PITRM1	0.435
ATP5D	0.435
GTPBP6	0.434
NDUFA6	0.434
OPA1	0.432
MRPS18B	0.432
MRPL33	0.43
MRPL38	0.429
TOMM6	0.428
MRPS11	0.427
NDUFA10	0.427
DHX30	0.426
MRPL11	0.426
COQ7	0.425
COQ6	0.425
SLC25A51	0.424
MRPL36	0.424
PDSS1	0.423
MRPL35	0.421
SLC25A3	0.421
NDUFB3	0.42
NDUFB4	0.417
MRPL28	0.417
TOMM22	0.416
NDUFC1	0.416
TMEM242	0.415
NDUFB2	0.41
MTRF1	0.41
ATP5A1	0.41
NOA1	0.409
NDUFB10	0.406
COQ3	0.405
ALDH18A1	0.403
IBA57	0.403
PDE12	0.402
TIMM17A	0.4
NDUFS1	0.4
COX20	0.4

Global Fraction of Cell Lines Where Essential: 18/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 263
Expression level (log2 read counts): 5.37

Expression Distribution

rRNA (uridine-2-O-)-methyltransferase activity
rRNA 2-O-methylation
rRNA methylation
rRNA modification
RNA methylation
RNA modification
rRNA processing
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
mitochondrial matrix
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
mitochondrion
RNA metabolic process
gene expression