MBTPS2

Gene Information

Official Symbol: MBTPS2
Official Name: membrane bound transcription factor peptidase, site 2
Aliases and Previous Symbols: N/A
Entrez ID: 51360
UniProt: O43462
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009].
UniProt Summary: Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-4.04
Fluvastatin 2.2μM R06 exp282	-3.43
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.79
Vemurafenib 6.6μM R08 exp434	-2.74
BH1 1μM R04 exp169	-2.62
GSK2606414 1μM R05 exp236	-2.61
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.45
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.37
Tunicamycin 0.04μM R07 exp418	-2.21
Parthenolide 2.5μM R05 exp238	-2.2
Q15 1 to 2μM on day4 R04 exp164	-2.16
Myriocin 25μM R06 exp293	-2.15
B02 10μM R08 exp453	-2.07
Golgicide-A 4μM R03 exp122	-2.07
L-74142 5μM R03 exp131	-2.03
Bisphenol S 100μM R08 exp458	-1.89
UM0125461 0.74μM R02 exp84	-1.89
Cincreasin 100μM R08 exp473	-1.87
Alda-1 10μM R06 exp262	-1.84
Geldanamycin 0.01μM R05 exp235	-1.84
Clomiphene 4.4μM R02 exp68	-1.83
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.83
Ethanol 0.01 R05 exp234	-1.83
All-trans-Retinoic-Acid 8μM R07 exp333	-1.78
ABT-702 0.1μM R06 exp260	-1.71
HMS-I2 1μM R06 exp286	-1.71
PFI-2 4μM R05 exp239	-1.7
Vemurafenib 6.6μM R02 exp89	-1.7
SNS-032 25μM R07 exp401	1.7
5-Azacytidine 2μM R07 exp330	1.72
R-DABN 8μM R03 exp111	1.72
DABN 20μM R00 exp17	1.73
Cannabidiol 13μM R08 exp465	1.76
MS023 7μM R03 exp135	1.76
BI-D1870 2μM R04 exp162	1.81
Genistein 15μM R07 exp360	1.82
Torin1 0.08μM R02 exp82	1.83
Doxorubicin 0.02μM R08 exp478	1.84
Mitomycin-C 0.06μM R08 exp503	1.84
QNZ 0.01μM R05 exp241	1.85
Palbociclib 1μM R07 exp382	1.87
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.88
35°C R06 exp302	1.89
Cytochalasin-B 5μM R07 exp349	1.91
Vinblastine 0.015μM R05 exp208	1.91
GSK-J4 1-1.25μM to day4 R07 exp363	1.92
Centrinone 0.5μM R07 exp343	1.94
Senexin-A 25μM R07 exp400	1.96
CCT251545 20μM R07 exp326	1.98
AICAR 240μM R05 exp211	2
Rotenone 0.07μM R08 exp431	2.02
Hinokiflavone 12μM R08 exp487	2.03
Aminopterin 0.005μM R07 exp335	2.06
Citral 75μM R06 exp275	2.06
Hippuristanol 0.12μM R08 exp488	2.07
Vinblastine 0.2μM R03 exp108	2.08
Rotenone 2μM R00 exp33	2.1
CoCl2 18μM R07 exp346	2.13
CAY10603 0.55μM R08 exp467	2.14
QNZ 0.01μM R08 exp439	2.17
PU-H71 1μM R08 exp515	2.27
Artemisinin 50μM R08 exp450	2.32
Calcium Ionophore 0.4μM R07 exp342	2.36
ONC212 0.15μM R08 exp513	2.37
Aphidicolin 0.4μM R08 exp440	2.4
VER-155008 3.9μM R06 exp301	2.4
5-Fluorouracil 20μM R00 exp2	2.44
LJH685 50μM R08 exp433	2.46
THZ1 0.06μM R08 exp531	2.46
DABN racemic mixture R03 exp93	2.55
CI-1040 9.5μM R08 exp472	2.56
Thimerosal 0.85μM R08 exp529	2.58
Benzoate 20000μM R08 exp456	2.59
Vitamin-D3 40μM R08 exp536	2.61
GSK-J4 1.5μM R08 exp441	2.67
Arsenate 40μM R06 exp264	2.71
Erlotinib 10μM R05 exp216	2.74
Tanespimycin 14μM R08 exp527	2.79
GSK461364A 0.1μM R03 exp126	2.8
BI-6727 0.0125μM R03 exp97	2.82
BI-2536 0.02μM R03 exp96	2.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.87
Hydroxyurea 100μM R07 exp329	2.87
BI-2536 0.0042μM R03 exp95	3.04
TIC10 10μM R08 exp532	3.38
Milciclib 2μM R08 exp502	3.49
Atovaquone 15μM R08 exp451	3.5
42°C R08 exp539	3.51
UM131593 0.2μM R03 exp106	3.51
Ammonium tetrathiomolybdate 10μM R08 exp448	3.53
Tubacin 1.6μM R07 exp416	3.55

Gene	Correlation
MBTPS1	0.698
ALG6	0.599
DPAGT1	0.573
DHRSX	0.57
SEC63	0.552
ALG1	0.534
UAP1	0.531
ATXN10	0.529
SEC62	0.527
SRD5A3	0.523
PMM2	0.521
ROMO1	0.517
ALG5	0.517
GFPT1	0.51
PPP6C	0.509
ATP5O	0.509
PDAP1	0.507
ALG8	0.505
CTDNEP1	0.502
THG1L	0.501
SRP14	0.497
USO1	0.493
ATP5A1	0.491
DOHH	0.486
ATP5B	0.485
BAP1	0.484
PGM3	0.484
ATP5D	0.483
ATP5J	0.478
DNAJC3	0.478
EIF1	0.476
CBFB	0.475
PPCS	0.473
SCAP	0.472
DOLK	0.469
CHKA	0.469
MPDU1	0.468
GTF3C4	0.467
SUPV3L1	0.467
VEZT	0.465
TRIAP1	0.464
TRMT10A	0.461
SSB	0.457
DPM3	0.451
EXOC4	0.451
POLR3C	0.447
RFT1	0.446
TRMT61A	0.444
ALG13	0.444
ATP5C1	0.443
KIAA1432	0.441
GET4	0.439
FH	0.439
RPIA	0.438
UBA5	0.438
KDSR	0.435
ALG2	0.432
UBE2G2	0.432
IRF2BP2	0.431
SEC16A	0.429
ATP2A2	0.429
RNMT	0.427
ENY2	0.427
TMEM41B	0.427
ELAC2	0.426
MRPL23	0.426
TPK1	0.425
TMED10	0.424
GMPPB	0.424
URM1	0.421
ALG3	0.42
TTC4	0.42
YARS2	0.419
VAPA	0.419
EEF1E1	0.418
OPA1	0.417
CEPT1	0.417
TAMM41	0.413
MRPS6	0.413
MRPS33	0.412
TAZ	0.411
PGGT1B	0.41
MRPS18A	0.41
KIAA0391	0.408
ORAOV1	0.408
MSTO1	0.408
DNLZ	0.407
TRNT1	0.406
CHCHD4	0.406
MED16	0.405
ZBTB11	0.404
C17orf89	0.404
TUFM	0.404
SLC25A19	0.403
LSM11	0.401
WBSCR16	0.4
TMEM242	0.4

Global Fraction of Cell Lines Where Essential: 290/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	19/26
bone	10/26
breast	10/30
central nervous system	17/49
cervix	1/4
colorectal	8/17
esophagus	6/11
fibroblast	1/1
gastric	5/14
kidney	6/18
liver	6/19
lung	28/72
lymphocyte	11/16
ovary	8/25
pancreas	4/22
peripheral nervous system	7/15
plasma cell	2/12
prostate	1/1
skin	9/20
soft tissue	5/9
thyroid	2/2
upper aerodigestive	14/22
urinary tract	16/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3228
Expression level (log2 read counts): 4.73

Expression Distribution

ATF6-mediated unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
bone maturation
membrane protein intracellular domain proteolysis
animal organ maturation
positive regulation of transcription from RNA polymerase II promoter in response to stress
ER-nucleus signaling pathway
membrane protein proteolysis
regulation of cholesterol biosynthetic process
regulation of sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
metalloendopeptidase activity
endoplasmic reticulum unfolded protein response
regulation of steroid metabolic process
cholesterol metabolic process
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
secondary alcohol metabolic process
sterol metabolic process
anatomical structure maturation
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
regulation of lipid biosynthetic process
bone development
developmental maturation
response to endoplasmic reticulum stress
steroid metabolic process
positive regulation of DNA-binding transcription factor activity
alcohol metabolic process
regulation of lipid metabolic process
regulation of DNA-binding transcription factor activity
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
skeletal system development
Golgi membrane
endoplasmic reticulum membrane