MRPL53

Gene Information

Official Symbol: MRPL53
Official Name: mitochondrial ribosomal protein L53
Aliases and Previous Symbols: N/A
Entrez ID: 116540
UniProt: Q96EL3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cisplatin 0.35μM R06 exp273	-2.02
2-Deoxy-D-glucose 800μM R05 exp214	-1.89
CHIR-124 0.04μM R06 exp272	-1.85
Lapatinib 5μM R01 exp47	-1.72
ETC-159 50μM R08 exp480	-1.71
CoCl2 18μM R07 exp346	1.85
Tubacin 1.6μM R07 exp416	1.86
LLY-283 2.6μM R06 exp290	1.97
Chloroquine 32μM R08 exp470	2
Etoposide 1μM R00 exp19	2.01
ONC212 0.15μM R08 exp513	2.04
GSK-J4 1.5μM R08 exp441	2.06
Arsenate 40μM R06 exp264	2.22
PU-H71 1μM R08 exp515	2.26
Deferoxamine 11μM R07 exp350	2.53
Thimerosal 0.85μM R08 exp529	2.86
Hydroxyurea 100μM R07 exp329	3.26

Gene	Correlation
MRPS21	0.706
HSD17B10	0.704
MRPL23	0.693
VARS2	0.684
MRPS5	0.675
TARS2	0.674
YARS2	0.672
MRP63	0.668
MRPS16	0.663
MRPS14	0.662
MRPS34	0.658
DAP3	0.658
GFM1	0.651
MRPL21	0.646
EARS2	0.644
RBFA	0.641
MRPS24	0.635
MRPS6	0.634
COX16	0.631
SCO2	0.623
NARS2	0.621
DARS2	0.621
SELRC1	0.62
QRSL1	0.618
MRPS26	0.615
RPUSD4	0.614
FASTKD5	0.613
MRPL12	0.611
SUPV3L1	0.611
SARS2	0.609
MRPS18A	0.605
TEFM	0.605
GATC	0.602
MRPS12	0.602
GFM2	0.602
MRPL47	0.602
MRPL45	0.598
COA6	0.598
PARS2	0.596
MRPS2	0.59
MRPS9	0.589
WBSCR16	0.588
KIAA0391	0.587
NDUFA3	0.583
BCS1L	0.583
MARS2	0.581
AARS2	0.58
HARS2	0.579
C12orf65	0.579
TUFM	0.577
LARS2	0.574
PET112	0.571
NDUFB11	0.57
RNASEH1	0.566
AIFM1	0.565
NDUFAF7	0.563
MRPL15	0.561
PNPT1	0.56
RARS2	0.559
MRPS33	0.559
MTG2	0.558
PDSS1	0.552
FTSJ2	0.551
MTG1	0.549
MRPL20	0.549
COQ2	0.548
GTPBP10	0.545
COA3	0.544
MRPL55	0.544
C10orf2	0.541
MTERFD2	0.538
MTPAP	0.537
CHCHD1	0.531
MRPS25	0.531
MRPS10	0.528
SLC25A26	0.526
MRPL4	0.523
RPUSD3	0.521
MRPL3	0.519
COX17	0.516
C17orf89	0.514
TOMM20	0.514
COX15	0.513
MTRF1L	0.51
MRPL34	0.509
MRPS35	0.509
METTL17	0.508
MRPL39	0.505
NDUFA2	0.505
FARS2	0.505
MRPL17	0.504
DHRSX	0.504
MRPL44	0.504
MRPS7	0.502
NDUFA1	0.501
MRPS17	0.499
CHCHD4	0.496
MRPL18	0.494
MRPL42	0.493
NDUFS7	0.492
NDUFB5	0.492
RNMTL1	0.489
POLG2	0.489
TFAM	0.486
MRPL11	0.486
COX11	0.485
ELAC2	0.483
POLG	0.482
COQ7	0.482
PET117	0.481
COX6C	0.481
MRPL36	0.481
OPA1	0.48
COX7B	0.48
MTERFD1	0.479
MRPS27	0.477
UQCRC2	0.477
MRPL33	0.477
ATP5D	0.476
MRPS23	0.475
COX5A	0.474
MALSU1	0.474
UQCC2	0.473
FH	0.472
MIPEP	0.471
NDUFC2	0.471
MRPS11	0.471
COQ4	0.47
CARS2	0.469
TFB1M	0.466
COQ6	0.466
POLRMT	0.466
MRPL43	0.465
TRMT10C	0.464
TRUB2	0.464
TIMM8B	0.464
ATP5SL	0.463
ACAD9	0.462
DNLZ	0.462
RPIA	0.462
NDUFAF3	0.459
HMGXB3	0.457
ALG6	0.457
FASTKD2	0.456
MTIF3	0.454
LRPPRC	0.454
UQCR10	0.452
PMM2	0.451
NDUFS2	0.45
NDUFA11	0.45
TOMM40	0.449
ATP5A1	0.448
TRIAP1	0.447
LSM10	0.447
NDUFV1	0.446
MRPL49	0.445
NDUFB6	0.443
NDUFAF4	0.443
AASDHPPT	0.443
PGM3	0.442
TMEM242	0.442
COQ3	0.442
ECSIT	0.441
MRPS28	0.436
MRPL37	0.436
TRMT61A	0.434
MRPL41	0.433
ATP5C1	0.433
NDUFB1	0.432
MRPL46	0.43
MRPS22	0.43
MRPL2	0.43
COX20	0.428
TMEM126B	0.428
GRSF1	0.428
NDUFB9	0.427
PTCD1	0.427
PPA2	0.426
DHX30	0.426
HIGD2A	0.425
SCO1	0.422
COA5	0.422
RTN4IP1	0.422
HCCS	0.422
SSBP1	0.421
PET100	0.418
MRPL13	0.418
WARS2	0.418
NDUFB3	0.418
TMEM261	0.418
MRPL28	0.417
ALG8	0.416
COQ5	0.416
GTPBP8	0.415
CRLS1	0.415
GTPBP6	0.415
MRPL22	0.413
TOMM22	0.413
MRPL27	0.41
MRPL1	0.408
COX6B1	0.408
NDUFA10	0.408
MRPL32	0.406
MCAT	0.406
PRKRIR	0.405
TOMM6	0.405
COX19	0.404
PTCD3	0.402
IBA57	0.401
MTIF2	0.4
SLC25A3	0.4
MRPL52	0.4

Global Fraction of Cell Lines Where Essential: 209/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	9/28
blood	8/28
bone	6/26
breast	12/33
central nervous system	11/56
cervix	3/4
colorectal	5/17
esophagus	9/13
fibroblast	0/1
gastric	6/16
kidney	3/21
liver	4/20
lung	18/75
lymphocyte	4/16
ovary	1/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	12/22
urinary tract	12/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1210
Expression level (log2 read counts): 3.87

Expression Distribution