MRPL47

Gene Information

Official Symbol: MRPL47
Official Name: mitochondrial ribosomal protein L47
Aliases and Previous Symbols: N/A
Entrez ID: 57129
UniProt: Q9HD33
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCT251545 20μM R07 exp326	-1.91
Dorsomorphin 5μM R07 exp357	1.73
CR131-b 0.005μM R08 exp474	1.76
Genistein 15μM R07 exp360	1.76
GSK-J4 1.5μM R08 exp441	1.76
Thimerosal 0.85μM R08 exp529	1.78
Arsenate 40μM R06 exp264	1.91
Amiloride 100μM R08 exp447	1.95
Oligomycin-A 20μM R00 exp26	1.95
TIC10 10μM R08 exp532	1.99
Tubacin 1.6μM R07 exp416	2.02
LLY-283 2.6μM R06 exp290	2.08
MK2206 4μM R08 exp504	2.16
Dynasore 7μM R08 exp436	2.22
Hydroxyurea 100μM R07 exp329	2.27

Gene	Correlation
MRPS34	0.72
MRPL21	0.683
YARS2	0.672
DAP3	0.672
MRPS14	0.67
HSD17B10	0.664
MRPS5	0.66
MRPS26	0.651
COX16	0.646
MRPS6	0.644
QRSL1	0.637
SCO2	0.636
MRPL23	0.635
FASTKD5	0.632
VARS2	0.628
DARS2	0.622
MARS2	0.621
SARS2	0.621
MRPS21	0.62
TARS2	0.618
NARS2	0.618
RPUSD4	0.616
MRPS18A	0.616
MRPS16	0.615
RBFA	0.611
KIAA0391	0.607
PARS2	0.606
MRP63	0.605
MTG2	0.603
MRPL53	0.602
SELRC1	0.602
GFM1	0.601
PNPT1	0.595
BCS1L	0.595
EARS2	0.594
MRPL45	0.589
MRPL33	0.587
LARS2	0.587
PET112	0.586
MRPL15	0.582
TUFM	0.58
NDUFA3	0.58
COA3	0.579
NDUFB11	0.577
SUPV3L1	0.577
GFM2	0.576
MRPS25	0.571
MRPS12	0.57
COX6B1	0.568
MRPS2	0.567
NDUFAF7	0.566
GTPBP10	0.566
METTL17	0.566
MRPS9	0.563
TEFM	0.562
FTSJ2	0.561
WBSCR16	0.56
MRPS24	0.559
HARS2	0.559
MRPL3	0.559
RARS2	0.558
MRPL34	0.557
MRPS10	0.554
PET117	0.554
COX17	0.553
POLRMT	0.551
TRUB2	0.547
MRPL42	0.546
MRPL4	0.543
MRPL22	0.541
FARS2	0.541
COX7B	0.541
NDUFA2	0.536
NDUFC2	0.536
GATC	0.535
MTERFD2	0.534
COQ2	0.534
SLC25A26	0.533
CHCHD1	0.533
MTPAP	0.532
C12orf65	0.532
COX15	0.53
MRPL12	0.53
MRPL20	0.53
COA6	0.528
RPUSD3	0.528
AARS2	0.528
MRPS11	0.527
UQCRC2	0.526
C10orf2	0.526
MTG1	0.523
ATP5SL	0.518
ATP5C1	0.518
MRPL18	0.511
MRPL39	0.51
DDX28	0.509
RNASEH1	0.507
ATP5A1	0.503
RTN4IP1	0.503
POLG	0.501
MTERFD1	0.5
NDUFB6	0.499
MRPL55	0.499
NDUFB9	0.498
TFAM	0.498
MRPS23	0.496
MTRF1L	0.496
PDSS1	0.494
TOMM20	0.492
HIGD2A	0.492
MRPL44	0.491
MRPS22	0.49
MRPL13	0.489
PGM3	0.489
MRPS7	0.488
ATP5D	0.488
COA5	0.488
AIFM1	0.487
NDUFA1	0.486
LRPPRC	0.485
NDUFB3	0.483
NDUFV1	0.482
MRPS35	0.481
NDUFAF4	0.481
POLG2	0.481
COX6C	0.481
C17orf89	0.48
MRPL52	0.479
RNMTL1	0.477
MRPL51	0.477
DHRSX	0.477
TRIAP1	0.475
MTIF3	0.475
TOMM22	0.474
COX11	0.474
MIPEP	0.472
MRPL41	0.472
TMEM242	0.471
NDUFS2	0.471
HMGXB3	0.467
UQCR10	0.466
PTCD3	0.466
DHX30	0.465
MRPS33	0.463
TIMM8B	0.462
CARS2	0.46
UQCRQ	0.458
COQ4	0.457
NDUFB5	0.457
MRPS17	0.457
PTDSS1	0.456
ATP5B	0.455
CYCS	0.454
AASDHPPT	0.449
NDUFAF3	0.449
ELAC2	0.448
GRSF1	0.446
MRPL43	0.446
NDUFA11	0.444
CHCHD4	0.443
MRPL1	0.443
SLC31A1	0.443
MRPL17	0.442
WARS2	0.44
ECSIT	0.44
HCCS	0.44
MALSU1	0.438
CLPP	0.438
CRLS1	0.436
PPA2	0.434
PTCD1	0.433
SSBP1	0.433
ACAD9	0.432
PET100	0.431
MTO1	0.431
PITRM1	0.43
TFB1M	0.43
MRPL36	0.43
COX19	0.429
GLRX5	0.429
FASTKD1	0.429
NDUFS7	0.429
FH	0.428
TOMM6	0.426
TOMM40	0.426
MRPL2	0.425
COX20	0.422
COQ7	0.42
ALAS1	0.42
ATP5O	0.42
DNLZ	0.418
NDUFC1	0.417
ATP5H	0.417
FASTKD2	0.417
NDUFAF1	0.414
MRPL49	0.414
NDUFA5	0.413
MRPL35	0.413
MRPL46	0.412
OPA1	0.412
PDSS2	0.412
ICT1	0.411
MCAT	0.411
SLC25A3	0.409
MRPL27	0.408
ROMO1	0.404
NUBPL	0.404
MRPS27	0.404
TMEM261	0.404
ATP5L	0.403
TAZ	0.403
MTIF2	0.402
COX7C	0.402
MRPS18B	0.401
MRPL11	0.4

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 871
Expression level (log2 read counts): 5.17

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
molecular function
cellular amide metabolic process
mitochondrion
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression