TAZ

Gene Information

Official Symbol: TAZ
Official Name: tafazzin
Aliases and Previous Symbols: N/A
Entrez ID: 6901
UniProt: Q16635
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Senexin-A 25μM R07 exp400	-2.13
Geldanamycin 0.01μM R05 exp235	-1.95
GSK-J4 1μM R07 exp362	-1.71
Alpha-Amanitin 0.5μM R00 exp5	-1.7
Rotenone 20μM R00 exp34	1.71
LJH685 50μM R08 exp433	1.73
GSK626616 14μM R08 exp485	1.8
Oligomycin-A 20μM R00 exp26	1.81
Pyridostatin 4μM R05 exp240	1.82
CFI-400945 25μM R08 exp469	1.83
Hypoxia 5%O2 R04 exp191	1.85
5-Fluorouracil 20μM R00 exp2	1.86
Bortezomib 0.05μM R00 exp7	1.9
ML-792 0.2μM R08 exp505	1.9
HMS-I1 10μM R06 exp256	1.91
Olaparib 4μM R08 exp512	1.91
Bleomycin 5μM R08 exp459	2
Quercetin 20μM R08 exp517	2.01
DABN 20μM R00 exp17	2.02
Amiloride 100μM R08 exp447	2.06
Hinokiflavone 12μM R08 exp487	2.06
CR131-b 0.005μM R08 exp474	2.08
Radicicol 0.16μM R05 exp242	2.08
Arsenate 40μM R06 exp264	2.1
Monensin 0.3μM R08 exp507	2.12
UMK57 1μM R01 exp59	2.12
BI-D1870 2μM R04 exp162	2.13
Actinomycin-D 0.01μM R00 exp4	2.15
Ibrutinib 10μM R08 exp442	2.19
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.21
AICAR 240μM R05 exp211	2.23
Etoposide 1μM R00 exp19	2.23
LLY-283 2.6μM R06 exp290	2.26
Benzoate 20000μM R08 exp456	2.27
JQ1 0.8μM R08 exp435	2.28
Pimelic-diphenylamide-106 5μM R00 exp28	2.3
KU-0063794 3.8μM R02 exp71	2.34
Aphidicolin 0.4μM R08 exp440	2.39
THZ1 0.06μM R08 exp531	2.51
CB-5083 0.4μM R08 exp468	2.53
Actinomycin-D 0.001μM R00 exp3	2.55
Nocodazole 0.2μM R00 exp24	2.57
R-DABN 8μM R03 exp111	2.6
Tanespimycin 14μM R08 exp527	2.6
42°C R08 exp539	2.66
PU-H71 1μM R08 exp515	2.7
SNS-032 15μM R08 exp443	2.82
Doxorubicin 0.02μM R08 exp478	2.86
MLN-4924 2μM R00 exp22	3.04
Staurosporine 0.02μM R08 exp524	3.04
Ammonium tetrathiomolybdate 10μM R08 exp448	3.05
Hippuristanol 0.12μM R08 exp488	3.06
Atovaquone 15μM R08 exp451	3.24
Rotenone 2μM R00 exp33	3.38
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.63
Thimerosal 0.85μM R08 exp529	3.74
GSK461364A 0.1μM R03 exp126	3.76
Dorsomorphin 5μM R07 exp357	4.36

Gene	Correlation
CRLS1	0.715
TRIAP1	0.676
OPA1	0.653
ROMO1	0.633
HARS	0.619
PMM2	0.614
TAMM41	0.592
SLC25A26	0.562
SRP14	0.556
DNLZ	0.554
DOHH	0.553
THG1L	0.55
RPE	0.538
TIMM13	0.534
UAP1	0.53
HCCS	0.529
ALG1	0.521
DPAGT1	0.52
SUPV3L1	0.519
ATP5A1	0.518
AARS	0.512
HSPD1	0.511
RTCB	0.505
PGGT1B	0.503
PPA2	0.501
CHCHD4	0.5
RNMT	0.5
GTF3C3	0.498
GFPT1	0.498
APAF1	0.498
CBFB	0.493
TRMT10A	0.491
ALG13	0.49
GNB1L	0.49
ALG2	0.486
RPTOR	0.484
GMPPB	0.483
UBE2G2	0.48
PPCS	0.48
ALG5	0.48
PLAA	0.48
ATP5O	0.477
TMEM41B	0.477
UQCRC2	0.476
TRNT1	0.476
CASP9	0.474
CYCS	0.473
UHRF1	0.472
KIAA0391	0.471
COQ3	0.47
DHPS	0.469
UBE2J1	0.468
MRPL23	0.467
PDSS1	0.465
NAE1	0.463
ATP5D	0.461
MRPS14	0.461
AASDHPPT	0.46
EXOC4	0.459
MRPS18A	0.453
ATP5B	0.452
ATXN10	0.452
PARL	0.451
BAK1	0.45
GTF3C6	0.449
CCT7	0.447
MRPL21	0.447
TIMM8B	0.447
TIMM17A	0.446
TKT	0.444
TUFM	0.444
UTP23	0.442
MRPS5	0.441
ATP5J	0.441
HAUS8	0.44
ALG6	0.44
EIF3F	0.437
RAB10	0.437
MRPS34	0.436
ORAOV1	0.435
IRF2BP2	0.435
MTOR	0.435
PAM16	0.431
MRPS11	0.431
MRPS9	0.428
RPN1	0.427
LSM11	0.427
DARS2	0.425
SLC25A20	0.424
DHRSX	0.423
TBCA	0.421
HIST1H4I	0.42
HSD17B10	0.42
PISD	0.42
LONP1	0.418
DUSP12	0.418
TPRKB	0.418
WBSCR16	0.418
BAP1	0.417
SEC62	0.417
WDR24	0.416
EIF4E	0.416
VEZT	0.416
PARS2	0.414
ATP5C1	0.413
SARS2	0.413
VRK1	0.413
VMP1	0.411
MRPS6	0.411
PGS1	0.411
MBTPS2	0.411
ATP2A2	0.41
PELO	0.409
RABIF	0.409
POLR3H	0.409
YARS2	0.409
PDPK1	0.409
MEAF6	0.408
PGM3	0.408
LSM10	0.408
TGS1	0.408
DAD1	0.408
GTF3C4	0.407
FAM210A	0.407
ZFP91	0.406
FASTKD5	0.406
VARS2	0.406
PPP2R3C	0.406
RPUSD4	0.405
ENO1	0.405
BCS1L	0.403
MRPL47	0.403
CEPT1	0.403
GTF2A2	0.403
HARS2	0.402
SUV420H1	0.402
LAMTOR4	0.402
CEP57	0.402
NSD1	0.402
UBA5	0.401
KDSR	0.401
FAF2	0.4

Global Fraction of Cell Lines Where Essential: 34/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	4/26
bone	1/26
breast	3/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	1/18
liver	0/19
lung	5/72
lymphocyte	6/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	1/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/28
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 18
Expression level (log2 read counts): 4.98

Expression Distribution

positive regulation of cardiolipin metabolic process
regulation of cardiolipin metabolic process
1-acylglycerophosphocholine O-acyltransferase activity
cardiolipin acyl-chain remodeling
cardiolipin biosynthetic process
O-acyltransferase activity
phosphatidylglycerol biosynthetic process
positive regulation of ATP biosynthetic process
cardiolipin metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
regulation of ATP biosynthetic process
positive regulation of nucleotide biosynthetic process
positive regulation of purine nucleotide biosynthetic process
phosphatidylglycerol metabolic process
cristae formation
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
inner mitochondrial membrane organization
positive regulation of nucleotide metabolic process
positive regulation of ATP metabolic process
positive regulation of purine nucleotide metabolic process
positive regulation of phospholipid metabolic process
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
cardiac muscle contraction
regulation of phospholipid metabolic process
heart contraction
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
heart process
striated muscle contraction
respiratory electron transport chain
oxidative phosphorylation
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
skeletal muscle tissue development
mitochondrial membrane organization
skeletal muscle organ development