TWISTNB

Gene Information

Official Symbol: TWISTNB
Official Name: TWIST neighbor
Aliases and Previous Symbols: N/A
Entrez ID: 221830
UniProt: Q3B726
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
POLR2J3	0.579
VASN	0.571
CBWD3	0.571
CBWD6	0.561
C1QTNF9B	0.56
KCTD17	0.559
PSMA6	0.557
HAP1	0.549
MED17	0.548
PSMB4	0.547
PRIM1	0.547
CDC45	0.543
TICRR	0.543
TCEB3CL2	0.541
TBC1D3H	0.534
CBWD5	0.532
COL2A1	0.524
CHD4	0.524
TBC1D3F	0.523
C14orf93	0.51
NUPL1	0.509
CEP192	0.508
RPS7	0.508
TCEB3C	0.508
GPRIN2	0.506
NBPF10	0.505
TCEB3CL	0.505
TBC1D3G	0.505
RPS2	0.505
DTL	0.505
RPL9	0.504
TP53TG3B	0.503
OR10G3	0.503
TP53TG3	0.502
IK	0.501
TP53TG3C	0.501
PSMD1	0.5
PSMB1	0.499
RFXANK	0.499
ZFAND5	0.497
NPIPB5	0.497
STIL	0.496
ORC1	0.496
GAR1	0.496
SSH2	0.494
PSMB2	0.494
TBC1D3	0.494
UPF1	0.492
TBC1D3C	0.492
DDTL	0.492
DNTTIP2	0.492
RPS12	0.491
PSMD2	0.49
SLC6A17	0.488
NOL10	0.485
ANKLE1	0.485
PSMD11	0.484
TFIP11	0.483
PBXIP1	0.482
COPE	0.482
TIMELESS	0.482
CDC6	0.48
RPS28	0.478
VPS54	0.477
COPG1	0.476
MYO1H	0.476
OGFR	0.474
FAM160A1	0.472
WDR75	0.472
TERF1	0.472
PCF11	0.471
AATF	0.471
SLC4A1	0.47
FBXO5	0.469
MT1E	0.469
NSF	0.469
GOLGA6A	0.467
PDE4DIP	0.467
S1PR4	0.466
CGB2	0.466
SUPT6H	0.466
ZNF830	0.466
UTP3	0.465
POLR2F	0.465
PSMA7	0.464
SCAF1	0.462
KRT78	0.462
POLR2D	0.461
AAMP	0.46
POLA2	0.46
NFATC4	0.46
IGFN1	0.459
RRN3	0.459
GOLGA8O	0.458
CMYA5	0.458
UTP20	0.458
CCNA2	0.457
ZNF655	0.457
PSMD3	0.457
RAD21	0.457
FAM86B2	0.457
DDT	0.456
RILPL1	0.456
RANBP2	0.455
GOLGA6B	0.455
COPA	0.455
KRT2	0.455
SULT1A3	0.454
ZNF541	0.453
SULT1A4	0.453
AKIRIN2	0.452
NUP133	0.452
RPS3A	0.452
GID4	0.451
TSPY8	0.451
ANKLE2	0.45
LRR1	0.449
CDC73	0.449
RPL35	0.449
EXOSC5	0.448
NUP160	0.448
TYMS	0.447
GOLGA6L3	0.447
TUBA8	0.447
SPRR2B	0.447
DDX56	0.447
PSMB3	0.446
ESF1	0.446
SUPT5H	0.445
NOL8	0.445
LOC643669	0.445
PSMC2	0.444
WDR87	0.443
RPL34	0.442
CHMP4B	0.442
FCN2	0.441
ZNF106	0.441
NPIPB8	0.441
RPS9	0.441
OSBP	0.44
RBBP5	0.44
ELMOD3	0.44
KIAA0947	0.439
RNPC3	0.439
PAN3	0.439
SAP30BP	0.439
NOP16	0.437
DISP2	0.436
TRAIP	0.436
RRP7A	0.436
POLR2J	0.435
HINFP	0.435
MYB	0.435
GOLGA6L4	0.435
COPB1	0.434
RNF121	0.433
RPS19BP1	0.433
MKI67IP	0.433
AQR	0.432
RPSA	0.431
GOLGA6L1	0.43
PSMC1	0.429
AHCTF1	0.429
TOP1MT	0.429
PLA2G4F	0.429
CCDC116	0.429
RFPL3	0.429
MYH7B	0.428
WAPAL	0.428
GGA3	0.428
ZMAT5	0.427
BYSL	0.427
HIST2H3A	0.427
HIST2H3C	0.427
WDR43	0.426
GOLGA6L6	0.426
ATXN1	0.425
PRR20C	0.425
ORC6	0.425
CCDC64B	0.425
PRR20A	0.425
TIPIN	0.424
PRR20D	0.424
PRR20E	0.424
PRR20B	0.424
BID	0.424
MED14	0.423
MAP7D1	0.423
ATP6AP1	0.423
BRIX1	0.422
SMG7	0.422
SH3BP1	0.422
PIGS	0.421
ATP6V0C	0.421
ATP6V1C1	0.421
TOPBP1	0.421
NDC80	0.421
DHX38	0.421
CHCHD3	0.42
COPB2	0.42
TONSL	0.42
TERF2	0.42
EXOSC9	0.42
RNF113A	0.419
RNF4	0.419
MADCAM1	0.418
MCOLN1	0.418
TSPY1	0.418
RAD51	0.418
POLE	0.418
PSMD14	0.418
OR11H6	0.417
SEMA6B	0.417
RRP15	0.417
CCDC94	0.416
SNIP1	0.416
POLR1A	0.416
TBC1D3I	0.416
MED15	0.416
TBC1D3E	0.416
FAM231A	0.416
TBC1D3L	0.416
FAM231C	0.416
PAN2	0.415
DIDO1	0.415
DOCK6	0.415
SMG1	0.415
TBC1D3K	0.415
PRPF8	0.414
RILPL2	0.414
PWP2	0.414
ACSF2	0.413
RIOK2	0.413
NOP56	0.412
DYNC1I2	0.412
ACBD4	0.411
NOL12	0.41
GBF1	0.41
MFSD12	0.41
RPL6	0.41
SRGAP2C	0.409
NARFL	0.409
TTK	0.409
HNRNPC	0.408
XYLT2	0.408
SF3A3	0.408
SPRR2A	0.407
RPS5	0.407
MPHOSPH10	0.407
SF3A1	0.407
SART1	0.407
INTS5	0.406
BRF2	0.405
HIVEP3	0.405
ATP6V1B2	0.405
CTR9	0.405
PARP3	0.404
CTAGE4	0.404
RPL14	0.404
SYT9	0.404
PSMA1	0.403
ATP1A3	0.402
NAALADL1	0.402
DAND5	0.401
PPFIA4	0.401
COX7A2L	0.401
SEC13	0.401
ATP6V0B	0.4
VPS28	0.4
SCGB1C1	0.4

Global Fraction of Cell Lines Where Essential: 455/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	17/28
blood	18/28
bone	13/26
breast	19/33
central nervous system	36/56
cervix	3/4
colorectal	10/17
esophagus	5/13
fibroblast	1/1
gastric	10/16
kidney	13/21
liver	13/20
lung	38/75
lymphocyte	10/16
ovary	22/26
pancreas	15/24
peripheral nervous system	12/16
plasma cell	8/15
prostate	0/1
skin	16/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	16/22
urinary tract	19/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 1230
Expression level (log2 read counts): 6.05

Expression Distribution

Screen	Score
Tunicamycin 0.04μM R07 exp418	1.76
SB202190 10μM R03 exp148	1.82

RNA polymerase I activity
RNA polymerase I complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular response to cytokine stimulus
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression